Dr. P.N Gupta

PK-PD, Toxicology & Formulation Division
CSIR - Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: pngupta@iiim.ac.in

Positions Held  
Position Held Date Organization
Senior Scientist 2010 - Present CSIR-IIIM

Honors & Awards

  • Ranbaxy Science Foundations, Research Scholarships Award for Young Scientist.

  • Bill & Melinda Gates foundation (USA) &Wellcome trust (UK) funded Postdoc fellowships.

  • National Doctoral Fellowship, All India Council of Technical Education (AICTE), New Delhi.

  • Senior Research Fellowship, Indian Council of Medical Research (ICMR), New Delhi.

Membership

  • Member, Academy of Pharmaceutical Sciences of Great Britain.

  • Member, Controlled Release Society-Indian Chapter.

  • Life Member, Indian Immunology Society.

Research Area

  • Pre-clinical formulation development for the institutional leads.

  • Controlled and targeted drug delivery for improved efficacy of the therapeutic agents.

  • Pre-clinical formulations for modulation of bioavailability.

  • Pre-formulation studies and pre-clinical formulations to support pharmacokinetics studies.

Publications
  • Saneja, A.; Nayak, D.; Srinivas, M.; Kumar, A.; Khare, V.; Katoch, A.; Goswami, A.; Vishwakarma, R.A.; Sawant, S.D.; Gupta, P.N. Development and mechanistic insight into enhanced cytotoxic potential of hyaluronic acid conjugated nanoparticles in CD44 overexpressing cancer cells, European Journal of Pharmaceutical Sciences, 2017, 97,79-91.

  • Dubey, R.D, Klippstein, R.; Wang, J.; Hodgins, N.; Mei K-C.; Sosabowski ,J.; Hider, R.C.; Abbate, V.; Gupta, P.N, Al-Jamal KT. Novel Hyaluronic Acid Conjugates for Dual Nuclear Imaging and Therapy in CD44-Expressing Tumors in Mice In Vivo, Nanotheranostics, 2017, 1, 59-79.

  • Saneja, A.; Kumar, R.; Singh, A.; Dubey, R.D.; Javed, M.; Singh, G.D.; Mondhe, D.M.; Panda, A.K.; Gupta, P.N. Development and evaluation of long-circulating nanoparticles loaded with betulinic acid for improved anti-tumor efficacy, International Journal of Pharmaceutics, 2017, 531, 153–166.

  • Saneja, A.; Sharma, L.; Dubey, R.D.; Javed, M.; Singh, A.; Kumar, A.; Sangwan, P.L.; Tasaduq, S.A.; Singh, G.D.; Mondhe, D.M.; Gupta, P.N. Synthesis, characterization and augmented anticancer potential of PEG-betulinic acid conjugate, Materials Science and EngineeringC, 2017, 73, 616-626.

  • Dubey, R.D.; Saneja, A.; Qayum, A.; Singh,  A.; Mahajan, G.; Chasso, G.; Kumar, A.; Andotra, S.S.;  Singh, S.K.; Singh, G.D.; Koul, S.; Mondhe, D.M.; Gupta, P.N. PLGA nanoparticles augmented the anticancer potential of pentacyclic triterpenediol in vivo in mice, RSC Advances, 2016, 6, 74586-74597.

  • Khare, V.; Sakarchi, W.A.; Gupta, P.N.; Curtis, ADM.; Hoskins, C. Synthesis and characterization of TPGS-gemcitabine prodrug micelles for pancreatic cancer therapy, RSC Advances, 2016, 6, 60126-60127.

  • Alam, N.; Qayum, A.; Kumar, A.; Khare, V.; Singh, S.;  Sharma, P.R.; Singh, S.K.; Koul, S.; Gupta, P.N. Improved efficacy of cisplatin in combination with a nano-formulation of pentacyclic triterpenediol. Materials Science and Engineering C, 2016, 68, 109-116.

  • Dubey, R.D.; Alam, N.; Saneja, A.; Khare, V.; Kumar, A.; Vaidh, S.; Mahajan, G.; Sharma, P.R.; Singh, S.K.; Mondhe, D.M.; Gupta, P.N. Development and evaluation of folate functionalized nanoparticles for targeted delivery of gemcitabine, International Journal of Pharmaceutics, 2015, 492(1-2), 80-91.

  • Khare, V.; Kour, S.; Alam, N.; Dubey, R.; Saneja, A.; Koul, M.; Gupta, A.P.; Singh, D.; Singh, S.K.; Saxena, A.K.; Gupta, P.N. Synthesis, characterization and mechanistic-insight into the anti- proliferative potential of PLGA-gemcitabine conjugate,International Journal of Pharmaceutics, 2014, 470, 51-62.

  • Gupta, P.N.; Pattani, A.; Curran, R.M.; Andrews, G.P.; Morrow, R.J.; Woolfson, A.D.; Malcolm, R.K. Development of liposome gel based formulations for intravaginal delivery of the recombinant HIV-1 envelope protein CN54gp140. European Journal of Pharmaceutical Sciences, 2012, 46, 315-322.

  • Pattani, A.; McKay, P.F,; Curran, R.M.; McCaffrey, J.; Gupta, P.N.; Lowry, D.; Kett, V.L.; Shattock, R.J.; McCarthy, H.O.; Malcolm, R.K. Molecular investigations into vaginal immunization with HIV gp41 antigenic construct H4A in a quick release solid dosage form, Vaccine, 2012, 30, 2778-2785.

  • Najar, I.A.; Sharma, S.C.; Singh, G.; Koul, S.; Gupta, P.N.; Javed, S.; Johri, R.K. Involvement of P-glycoprotein and CYP 3A4 in the enhancement of etoposide bioavailability by a piperine analogue. Chemico-Biological Interactions, 2011, 190, 84-90.