Dr. Mohd Jamal Dar

Cancer Pharmacology Division
CSIR - Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: jamal@iiim.ac.in

Positions Held  
Position Held Date Organization
Senior  Scientist   CSIR-IIIM
 
Membership  
  • International Society for Genomic and Evolutionary Microbiology(ISOGEM)-Life-time member

  • American Society for Investigative Pathology (ASIP)- (2009-2010)

  • American association of Experimental Biology (EB) -2010-2011

Research Area

Mohd Jamal Dar received PhD from the department of Molecular Biology and Genetics Unit ( MBGU) at Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) under the supervision of Prof. Namita Surolia. He then joined as a postdoctoral fellow at Harvard Medical School / Dana-Farber Cancer Institue with the group of Prof. Alan Engelman and worked on. HIV-1 integrase,  the enzyme responsible for the insertion of the viral DNA into host DNA, as the critical target of anti-AIDS therapy. Following this he worked as a Research Associate (Staff Scientist) with Prof. Paul Monga at University of Pittsburgh Medical Centre (UPMC) and investigated the role of wnt/beta-catenin signaling in cancer and stem cell biology.

Present Research Interest

Stem Cell Biology and Regenerative Medicine:

  • The role of wnt /beta-catenin signalling in cancer and stem cell biology.

  • The role of PI3K pathway  in cancer and stem cell biology.

Publications
  • Singh, P.; Bano, N.; Hossain, M.M.; Basit, R.; Dar, M.J. p110α and p110β isoforms of PI3K are involved in protection against H2O2 induced oxidative stress in cancer cells. Breast Cancer (2018).

  • Rather, M.A.; Lone, A.M.; Teli, B.; Bhat, Z.S.; Singh, P.; Maqbool, M.; Shairgojray, B.A.; Dar, M.J.; Amin, S.; Yousuf, S.K.; Bhat, B.A.; Ahmad, Z. The synthesis, biological evaluation and structure-activity relationship of 2-phenylaminomethylene-cyclohexane-1,3-diones as specific anti-tuberculosis agents. Medchemcomm (2017), 8(11):2133-2141. 

  • Jamwal, G.; Singh, G.; Dar, M.S.; Singh, P.; Bano, N.; Syed, S.H.; Sandhu, P.; Akhter, Y.; Monga, S.P.; Dar, M.J. Identification of a unique loss-of-function mutation in IGF1R and a crosstalk between IGF1R and Wnt/β-catenin signaling pathways.  Biochim Biophys Acta (2018), doi: 10.1016/j.bbamcr.2018.03.013.

  • Hussain, A.; Rather, M.A.; Dar, M.S.; Dangroo, N.A.; Aga, M.A.; Qayum, A.; Shah, A.M.; Ahmad, Z.; Dar, M.J.; Hassan, Q.P. Streptomyces puniceus strain AS13., Production, characterization and evaluation of bioactive metabolites: A new face of dinactin as an antitumor antibiotic.  Microbiol Res  (2018) ,196-202.

  • Rather, M.A.; Lone, A.M.;  Teli, B.;    Bhat, Z.S.; Singh, P.; Maqbool, M.;  Shairgojray, B.A.; Dar, M.J.;  Amin, S.;   Yousuf, S.K.; Bhat, B.A.;  Ahmad, Z . Synthesis, Biological Evaluation and Structure-Activity Relationship of 2-Phenylaminomethylene-cyclohexane-1,3-diones  as Specific Anti-tuberculosis Agents. MedChemComm ,8 (11), 2133-2141.

  • Dar, M.S.; Singh, P; Mir, R.A.; Dar, M.J. Βeta-catenin N-terminal domain: An enigmatic region prone to cancer causing mutations Mutation Research/Reviews in Mutation Research-(2017).

  • Dar, M.S.; Hussain, A.; Singh, P.; Hassan, Q.P.; Monga, S.P.; Dar, M.J .Identification of a natural product small molecule inhibitor against Wnt/β-catenin signalling pathway. AACR.  Cancer Research (2017),77 ,13, 333-333.

  • Singh, P.; Dar ,M.S.; Dar, M.J. p110α and p110β isoforms of PI3K signaling: are they two sides of the same coin? FEBS Lett  (2016) ,590(18):3071-82.

  • Dar, M.S.; Singh, P.; Singh ,G.; Jamwal, G.; Hussain, S.S.; Rana, A.; Akhter ,Y.; Monga, S.P.; Dar, M.J. Terminal regions of β-catenin are critical for regulating its adhesion and transcription functions. Biochim Biophys Acta (2016) ,1863(9):2345-57. doi: 10.1016/j.bbamcr.2016.06.010.

  • Singh, P.; Dar, M.; Singh, G.; Jamwal, G.; Sharma, P.R.; Ahmed, M.; Dar, M.J. "Dynamics of GFP-fusion p110α and p110β isoforms of PI3K signaling pathway in normal and cancer cells". J Cell Biochem  (2016 ), 117(12):2864-2874.

  • Hussain, A.; Qazi, A.K.; Mupparapu, N.; Guru, S.K.; Kumar, A.; Sharma, P.R.; Singh S.K.; Singh, P.; Dar, M.J.; Bharate, S.B.; Zargar, M.A.; Ahmed, Q.N. Bhushan, S.; Vishwakarma, R.A. Hamid A. Modulation of glycolysis and lipogenesis by novel PI3K selective molecule represses tumor angiogenesis and decreases colorectal cancer growth. Cancer Lett. (2016), 374(2):250-60. 

  • Dar, M.S.; Singh, P.; Singh, G.; Jamwal, G.; Dar, M.J. Analyzing the biophysical properties and elucidating nuclear functions of beta-catenin and its mutants. FEBS JOURNAL. (2014), 281, 435-435.

  • Thompson, M.D.; Dar, M.J.; Monga, S.P. Pegylated interferon alpha targets Wnt signaling by inducing nuclear export of  β-catenin.  Journel of  Hepatol (2011) ,54(3):506-12.

  • Dar, M.J.; Thompson, M.D.; Monga, S.P. Pegylated interferon 2-alpha mediated down-regulation of Wnt/beta-catenin pathway via up-regulation of nuclear export factor
    RanBP3'. The FASEB Journal (2010) .

  • Dar, M.J.; Monga, S.P. Regucalcin mediated up-regulation of Wnt/{beta}-catenin signaling. The FASEB Journal (201l) .

  • Kari , N.; Nejak-Bowen.;  Michael, D.; Thompson, S.;  Singh, W.C. Bowen,  J.; Dar, M.J.; Jaspal, K.; Chunsun, D.; Satdarshan, P.S. Accelerated liver regeneration and hepatocarcinogenesis in mice overexpressing serine-45 mutant beta-catenin. HEPATOLOGY, (2010) ,51(5):1603-13

  • Hughes, S.; Jenkins, V.; Dar, M.J.; Engelman, A.; Cherepanov, P. Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activity. J Biol Chem. (2010) ,285(1):541-54.  

  • Krishnan, L.; Matreyek, K.A.; Oztop, I.; Lee, K.; Tipper, C.H.; Li, X.; Dar ,M.J.; Kewalramani, V.N.; Engelman, A.  The  requirement  for  cellular  transportin  3  (TNPO3  or  TRN-SR2)  during infection maps to human  immunodeficiency virus type 1 capsid and not integrase. J Virol. (2010) ,84(1):397-406

  • Dar, M.J.;  Monel, B.;  Krishnan, L.; Shun , M.C.;  Di, N.F.;  Helland, D.E.;  Engelman, A. Biochemical and virological analysis of the 18-residue C-terminal tail of HIV-1 integrase. Retrovirology. (2009), 19;6:94.

  • McKee, C.J.;  Kessl, J.J.;  Shkriabai, N.;  Dar, M.J.;  Engelman, A.;  Kvaratskhelia, M.  Dynamic modulation of  HIV-1 integrase structure and function by cellular LEDGF protein. J Biol Chem. (2008), 14;283(46):31802-12.

  • Dar, J.A.; Thoker, M.A.; Khan, J.A.; Ali, A.; Khan, M.A.; Bhat, K.H.; Dar, M.J.; Ahmed, N.; Ahmed, S. Molecular epidemiology of clinical and carrier strains of methicillin resistant Staphyloccus aureus  (MRSA)  in the hospital settings of north India. Ann Clin Microbiol Antimicrob.(2006) ,5:22.

  • Kapoor, M.; Dar, M.J.; Surolia, A.; Surolia, N. Kinetic determinants of the interaction of Enoyl- ACP Reductase  from Plasmodium falciparum with its substrates and inhibitors. Biochem Biophys Res Commun. (2001), 289(4): 832-7.

Current Ph.D Students

1
Nasima Bano
2
Md. Mehdi Hossain
3
Rafi  Basit
4
Aadil Qadir

Alumni -Ph.D students

1
Paramjeet Singh   
2
Gurjinder Singh
3
M. Saleem Dar
4
Gayatri Jamwal