Dr. Asha Chaubey

Fermentation Technology Division
CSIR - Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: achaubey@iiim.ac.in

Positions Held  
Position Held Date Organization
Sr. Scientist 2010 - Present CSIR-IIIM
Scientist 2006 - 2010 CSIR-IIIM
Jr. Scientist 2003 - 2003 CSIR-IIIM

Honours & Awards

  • Best Poster Award during Sixth Asian Conference on Solid State Ionics, 29 Nov.-4 Dec, 1998, Surajkund, Haryana, India.
  • Best Poster Awardduring4th National Conference on Solid State Ionics, 3-5 March, 2000 at Indian Institute of Technology, Mumbai, India.

Membership

  • Life member of ‘Biosensor Society of India’.

Research

  • Isolation characterization of microorganisms including endophytes and extremophiles for novel bioactives/biocatalysts and their chemo profiling.

  • Novel microbial enzymes of pharmaceutical importance specifically lipases, nitrilases and aldolases, biotransformations and kinetic resolution of drug/drug intermediates.

  • Enzyme immobilization and enzymatic processes using free and immobilized enzymes.

 

Publications

Click here for complete list.

  • Singh, V.P.; Yedukondalu, N.; Sharma, V.; Kushwaha, M.; Sharma, R.; Chaubey, A.; Kumar, A.; Singh, D.; Vishwakarma, R.A.  Lipovelutibols A−D: Cytotoxic Lipopeptaibols from the Himalayan Cold Habitat Fungus Trichoderma velutinum. Journal of Natural Products 81 (2018) 219-226.

  • Sharma ,R.; Magotra , A.; Manhas, R.S.; Chaubey ,A.; Antagonistic potential of a psychrotrophic fungus: Trichoderma velutinum ACR-P1. Biological Control 115 (2017) 15-17.

  • Sharma, R.; Jamwal, V. L.;  Singh, V. P.;  Awasthi, P.; Singh, D.; Vishwakarma, R. A.  Gandhi, S. G.  Chaubey, A. Revelation and cloning of valinomycin synthetase genes in Streptomyces lavendulae ACR-DA1 and their expression analysis under different fermentation and elicitation conditions. J Biotechnol. 253 (2017) 40-47.

  • Magotra, A.; Kumar, M.; Kushwaha, M.; Awasthi, P.;  Raina, C.; Gupta, A P.; Bhahwal A. S.; Gandhi, S.G.; Chaubey, A. Epigenetic modifier induced enhancement of fumiquinazoline C production in Aspergillus fumigatus (GA-L7): an endophytic fungus from Grewia asiatica L.AMB Expr (2017) 7:43.

  • Qadri, M.; Nalli, Y.; Jain, S. K.  Chaubey, A.; Ali, A .; Strobel, G. A.; Vishwakarma, R. A.;  Riyaz-Ul-Hassan, S. An Insight into the Secondary Metabolism of Muscodor yucatanensis: Small-Molecule Epigenetic Modifiers Induce Expression of Secondary Metabolism-Related Genes and Production of New Metabolites in the Endophyte. Microbial Ecology, 73(4) (2017) 954–965.

  • Sharma, R.; Singh, V. P. ; Singh, D.;  Yusuf, F.; Kumar, A.;  Vishwakarma, R. A. ; Chaubey, A. Optimization of nonribosomal peptides production by a psychrotrophic fungus: Trichoderma velutinum ACR-P1.Appl Microbiol Biotechnol 100(21) (2016) 9091-9102.

  • Sharma R.; Lambu, M. R. .; Jamwal, U.;  Rani, C.;  Chib, R.; Wazir, P.; Mukherjee, D.; Chaubey, A.; Khan, I. A. Escherichia coli N-Acetylglucosamine-1-Phosphate-Uridyltransferase/Glucosamine-1- Phosphate-Acetyltransferase(GlmU) Inhibitory Activity of Terreic Acid Isolated from Aspergillus terreus. J. Biomol. Screening, 21(4) (2016) 342–353.

  • Koul, M.;  Meena, S.;  Kumar, A.; Sharma, P. R.; Singamaneni, V.;  Riyaz-Ul-Hassan, Syed .; Hamid, A.;  Chaubey, A.;  Prabhakar, A.;  Gupta, P.;  Singh, S. Secondary Metabolites from Endophytic Fungus Penicillium pinophilum Induce ROS-Mediated Apoptosis through Mitochondrial Pathway in Pancreatic Cancer Cells.  Planta Med 2016; 82(04): 344-355.

  • Nalli, Y .;Mirza, D. N. ; Wani, Z. A.;  Wadhwa, B.; Mallik, F. A. ; Raina, C.; Chaubey, A.; Riyaz-Ul-Hassan, S.; Ali, A. Phialomustin A-D, new antimicrobial and cytotoxic metabolites from an endophytic fungus,  Phialophora mustea. RSC Advances  5 (2015) 95307–95312.

  • Yusuf, F.; Rathar, I. A .; Gandhi, S. G.; Jamwal, U.;  Chaubey, A. Cloning, heterologous expression and functional characterization of nitrilase from   Fusarium proliferatum AUF-2.Functional & Integrative Genomics 15 (2015) 413-424.

  • Magotra, A.; Nalli, Y.; Kushwaha, M.;  Raina, C.;   Gupta, A. P.; Ali, A.; Vishwakarma, R. A .; Chaubey, A.;  An efficient liquid chromatography tandem mass-spectrometry method for the quantification of borrelidin from Streptomyces rochei (ATCC 10739).J. Chem Technol & Biotechnol. (2014), DOI: 10.1002/jctb.4562).

  • Gupta, P.; Rouf, A.; Shah, B. A.; Mahajan, N.; Chaubey, A.; Taneja, S. C. Arthrobacter sp. Lipase catalyzed kinetic resolution of BINOL: The effect of substrate immobilization .J Mol Cat B 101 (2014) 35-39.

  • Yusuf, F.;  Chaubey, A.; Jamwal, U. Parshad, R . A new isolate from Fusarium proliferatum (AUF-2) for efficient nitrilase production .Appl. Biochem. Biotechnol.  171 (2013) 1022-1031.

  • Yusuf, F.; Chaubey, A.;  Raina, A.;  Jamwal, U.;  Parshad, R.;  Enhancing nitrilase production from Fusarium proliferatum using response surface methodology.SpringerPlus 2 (2013) 290.

  • Chaubey, A.; Raina, C.;  Parshad, R.; Rouf, A.;  Gupta, P.; Taneja, S. C. Bioconversion of sucralose-6-acetate to sucralose using immobilized microbial enzymes. J Mol Cat B 91 (2013) 81-86.

  • Rouf, A.; Gupta, P.;  Aga, M.A.;  Kumar, B.; Chaubey, A.; Parshad , R.; Taneja, S.C. Chemoenzymatic synthesis of piperoxan, prosympal, dibozane and doxazosin. Tetahedron Asymmetry 23 (2012) 1615-1623. 

  • Chaubey, A.;  Parshad, R.; Taneja, S. C. ; Deokar, S.;  C.R. Rajan, S. Ponrathnam,. Immobilization of enantioselective lipase on soluble supports for kinetic resolution of drug intermediates. J. Bioact. Compat. Polym. 27(2012) 499-509.

  • Marcheschi, R. J.;  Zhang, K.; Noey, E.L. ; Kim, S. ; Li, H.; Chaubey, A.;  Houk, K.N. ; Liao, J. C.. A Synthetic Recursive “+1” Pathway for Carbon Chain Elongation.ACS Chem Biol. 7 (2012) 689–697.

  • Chaubey, A .; Parshad, R.;  Taneja ,S. C. ; Qazi, G. N.. Arthrobacter sp. Lipase immobilization on magnetic sol-gel composite supports for enantioselectivity improvement.Process Biochemistry 44 (2009) 154–160.

  • Chaubey, A.; Parshad, R.;  Gupta, P.;  Taneja, S. C. ; Qazi, G. N. ; Rajan, C. R. ; Ponrathnam, S. Arthrobacter  sp. lipase immobilization for preparation of enantiopure masked b-a,mino alcohols. Bioorganic Medicinal Chem 17 (2009) 29-34.

  • Enantiomerically pure a-methoxyaryl acetaldehydes as versatile precursors: a facile   chemo-enzymatic methodology for their preparation. Singh, B.;  Gupta, P.;  Chaubey, A.; Parshad, R.; Sharma, S.; Taneja , S.C .;Tetrahedron Asymmetry 19 (2008) 2579-2588.

Patents

  • Pandey ,M. K.; Chaubey, A.; Pande, K. K.; Sharma, R. K.; Saini, K. K.; Malhotra, B.D.; Rajesh. Lactate biosensing strip.( CA 2512281,March 2010).

  • Pandey ,M. K.; Chaubey, A.; Pande, K. K.; Sharma, R. K.; Saini, K. K.; Malhotra, B.D.; Rajesh. Method for preparing lactate biosensing strip; (CA 2512279, June 2010).

  • Pandey ,M. K.; Chaubey, A.; Pande, K. K.; Sharma, R. K.; Saini, K. K.; Malhotra, B.D.; Rajesh. Method for manufacture of lactate biosensing strip. (United States Patent No 7364873, April, 2008).

  • Pandey ,M. K.; Chaubey, A.; Pande, K. K.; Sharma, R. K.; Saini, K. K.; Malhotra, B.D.; Rajesh. Lactate biosensing strip with two electrodes. (United States Patent No. 7, 319, 018, January 2008).

  • Pandey ,M. K.; Chaubey, A.; Pande, K. K.; Sharma, R. K.; Saini, K. K.; Malhotra, B.D.; Rajesh. Lactate biosensing strip. ( European  Patent No. EP 1 578 985 B1 ,  October 2007).

  • Kumar, A.; Chaubey, A.; Rajesh.; Malhotra, B.D. A novel conducting polymer based electrode for the estimation of cholesterol in aqueous solution.( United States Patent No. Us 7,175,746 B2 , February 2007).

  • Pandey ,M. K.; Chaubey ,A.;  Pande ,K.K.; Rajesh.;  Sharma, R. K., Saini, K. K.; Malhotra ,B.D. ; Rajesh. Process for the preparation of lactate biosensing strip useful for the preparation of lactate in aqueous solution. (Indian Patent No. 197458 ,August 2006).