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Representative Publications of IIIM

In Press | 2017 | 2016 | 2015 | 2014 | 2013

 

In Press

1
Malik, A.H.; Ashraf, N. Transcriptome wide identification, phylogenetic analysis, and expression profiling of zinc-finger transcription factors from Crocus sativus L. Mol Genet Genomics, DOI 10.1007/s00438-017-1295-3.
2
Rasool, R.U.; Rah, B.; Amin, H.; Nayak, D.; Chakraborty, S.; Rawoof, A.; Mintoo, M.J.; Yousuf, K.; Mukherjee, D.; Kumar, L.D.; Mondhe, D.M.; Goswami. Dual modulation of Ras-Mnk and P13K-AKT-MTOR pathways : A novel C-FLIP inhibitory mechanism of 3-AWA mediated translational alternation through dephosphorylation of eIF4E. Scientific Reports, DOI: 10.1038/srep18800.
3
Dhar, N.; Razdan, S.; Rana, S.; Bhat, W.W.; Vishwakarma, R.A.; Lattoo, S.K. A decade of molecular understanding of withanolide biosynthesis and in vitro studies in Withania somnifera (L.) Dunal: Prospects and perspectives for pathway engineering. Frontiers in Plant Science, DOI: 10.3389/fpls.2015.01031.

 

Representative Publications During 2017

1
Vishwakarma, R.A. Editorial: Medicinal Chemistry Research in India. ACS Medicinal Chemistry Letters, 2017, 8, 270-272.
2
Baba, S.A.; Vishwakarma, R.A.; Ashraf, N. Functional characterization of CsBGlu12, a ß-glucosidase from Crocus sativus provides insights into its role in abiotic stress through accumulation of antioxidant flavonols. The Journal of biological chemistry, 2017, 292, 4700 –4713.

 

Representative Publications During 2016

 

1
Pandith, S.A.; Dhar, N.; Rana, S.; Bhat, W.W.; Kushwaha, M.; Gupta, A.P.; Shah, M.S.; Vishwakarma , R.A.; Latoo, S.K. Characterization and functional promiscuity of two divergent paralogs of Type III plant polyketide synthases from Rheum emodi Wall ex. Meissn. Plant Physiology, 2016,171,2599-619
2
Rao, D.N.; Rasheed, S.K.; Das, P. Palladium/Silver Synergistic Catalysis in Direct Aerobic Carbonylation of C(sp2)−H Bonds Using DMF as a Carbon Source: Synthesis of Pyrido-Fused Quinazolinones and Phenanthridinones. Organic Letters, 2016, 18,3142–3145.
3
Rao, D.N.; Rasheed, S.K.; Kumar, K.A.; Reddy, A.S.; Das, P. Copper-Catalyzed CNH2 Arylation of 2 Aminobenzimidazoles and Related C-Amino-NH-azoles. Advanced Synthesis & Catalysis, 2016, 358,2126–2133.
4
Mehra, R.; Rajput, V.S.; Gupta, M.; Chib, R.; Kumar, A.; Wazir, P.; Khan, I.A.; Nargotra, A. Benzothiazole Derivative as a Novel Mycobacterium tuberculosis Shikimate Kinase Inhibitor: Identification and Elucidation of Its Allosteric Mode of Inhibition. Journal of Chemical Information and Modeling, 2016, 56, 930-40.
5
Kumar, K.A.; Kannaboina, P.; Jaladanki, C.K.; Bharatam, P.V.; Das, P. Copper-Catalyzed N-Arylation of Tautomerizable Heterocycles with Boronic Acids and Its Application to Synthesis of Oxygenated Carbazoles. Organic & Supramolecular Chemistry, 2016, 1, 601-607.
6
Amin, H.; Nayak, D.; Ur, R.; Chakraborty, S.; Kumar, A.; Yousuf, K.; Sharma, P.R.; Ahmed, Z.; Sharma, N.; Magotra, A; Mukherjee, D.; Kumar, L.D.; Goswami. A.Par-4 dependent modulation of cellular β-catenin by medicinal plant natural product derivative 3-azido Withaferin A. Molecular Carcinogenesis, 2016, 55, 864-81.
7
Magotra, A.; Nalli, Y.; Kushwaha, M.; Raina, C.; Gupta, A.P.; Ali, A.; Vishwakarma , R.A.; Chaubey, A. An efficient liquid chromatography tandem mass-spectrometry method for the quantification of borrelidin from Streptomyces rochei (ATCC 10739). Journal of Chemical Technology and Biotechnology, 2016, 91, 198–203.
8
Kannaboina, P.; Kumar, K.A.; Das, P. Site-Selective Intermolecular Oxidative C‑3 Alkenylation of 7-Azaindoles at Room Temperature. Organic Letters, 2016, 18, 900-903.
9
Mehra, R.; Rani, C.; Mahajan, P.; Vishwakarma, R.A.; Khan, I.A.; Nargotra, A. Computationally Guided Identification of Novel Mycobacterium tuberculosis GlmU Inhibitory Leads, Their Optimization, and in Vitro Validation. ACS Combinatorial Science, 2016, 18, 100-16.
10
Sharma, R.; Patel, N.; Vishwakarma, R.A.; Bharatam, P.V.; Bharate, S.B. Metal-free oxidative cyclization of acetophenones with diamines: A facile access to phenylpyridines. Chemical Communications, 2016, 52, 1009-1012.

 

Representative Publications During 2015

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1
Rasheed, S.K.; Rao, D.N.; Das, P. Copper-Catalyzed Inter-and Intramolecular C-N Bond Formation: Synthesis of Benzimidazole-Fused Heterocycles. The Journal of Organic Chemistry, 2015, 80, 9321–9327.
2
Battula, S.; Kumar, A.; Gupta, A.P.; Ahmed, Q.N. 2-Oxo-Driven N2 Elimination Induced Decarbonylative Cyclization Reaction in Benzotriazoles to 6-Aminophenanthridines. Organic Letter, 2015, 17, 5562-5565.
3
Mupparapu, N.; Khushwaha, M.; Gupta, A.P.; Singh, P.P.; Ahmed, Q.N. Amino Catalytic Oxidative Thioesterification Approach to a-Ketothioesters. Journal of Organic Chemistry, 2015, 80, 11588-11592.
4
Battula, S.; Kumar, A.; Ahmed, Q.N. Metal-Free Oxidative Cleavage of C-C bond in α-Hydroxy-β-oxophosphonates. Organic & Biomolecular Chemistry, 2015, 13, 9953-9956.
5
Yempalla, K.R.; Munagala, G.; Singh, S.; Magotra, A.; Kumar, S.; Rajput, V.S.; Bharate, S.S.; Tikoo, M.; Singh, G. D.; Khan, I.A.; Vishwakarma, R.A.; Singh, P.P. Nitrofuranyl Methyl Piperazines as New Anti-TB agents:Identification, Validation, Medicinal Chemistry and PK Studies. ACS Medicinal Chemistry Letters, 2015, 6, 1041-1046.
6
Reddy, K.R.; Reddy, A.S.; Shankar,R.; Kant, R.; Das, P. Copper-Catalyzed Oxidative C-H Amination: Synthesis of Imidazo[1,2-a]-N-Heterocycles from N-Heteroaryl Enaminones. Asian Journal of Organic Chemistry, 2015, 4, 573-583.
7
Aravinda Kumar, K. A.; Venkateswarlu, V.; Vishwakarma, R. A.; Sawant S. D. A Metal-Free Approach to Carboxylic Acids by Oxidation of Alkyl, Aryl, or Heteroaryl Alkyl Ketones or Arylalkynes. Synthesis, 2015, 47, 3161-3168.
8
Battula,S.; Battini,N.; Singh, D.; Ahmed, N.Q. 2-Oxo Promoted Hydrophosphonylation & Aerobic Intramolecular Nucleophilic Displacement Reaction. Organic & Biomolecular Chemistry, 2015, 13, 8637-8641.  
9
Venkateswarlu, V.; Pathania, A. S.; Aravinda, K.A.; Mahajan, P.; Nargotra, A.; Vishwakarma, R. A.; Malik, F.A.; Sawant, S.D. 4-(N-phenyl-N'-substituted benzenesulfonyl)-6-(4-hydroxyphenyl)quinolines as Inhibitors of Mammalian Target of Rapamycin. Bioorganic & Medicinal Chemistry,  2015, 23, 4237-47.
10
Venkateswarlu, V.; Aravinda, K.A.; Gupta, S.; Singh, D.;  Vishwakarma, R.A.; Sawant, S.D. DMSO/I2 mediated C-C bond cleavage of a-ketoaldehydes followed by C-O bond formation: A metal-free approach for one-pot esterification. Organic & Biomolecular Chemistry, 2015, 13, 7973-7978.
11
Bharate, J.B.; Abbat, S.; Bharatam, P.V.; Vishwakarma, R.A.; Bharate, S.B. CuBr catalyzed aerobic oxidative coupling of 2-aminopyridines with cinnamaldehydes: Direct access to 3-formyl-2-phenyl-imidazo[1,2-a]pyridines. Organic and Biomolecular Chemistry, 2015, 13, 7790-7794.
12
Balgotra, S.; Venkateswarlu, V.; Vishwakarma, R.A.; Sawant, S.D.  Direct C-N bond cleavage of N-vinyl or N-allyl arylamines: A metal-free strategy for N-devinylation and N-deallylation. Tetrahedron Letters, 2015, 56, 4289-4292.
13
Guru, S.K.; Pathania, A.S.; Kumar,S.; Ramesh, D.; Kumar, M.; Rana, S.; Kumar, A.; Malik, F.; Sharma, P.R.; Chandan, B.K.; Jaglan, S.; Sharma, J.P.; Shah, B.A.; Tasduq, S.A.; Lattoo, S.K.; Faruk, A; Saxena, A.K.; Vishwakarma, R.A.; Bhushan, S. Secalonic acid-D represses HIF-1a/VEGF mediated angiogenesis by regulating the Akt/mTOR/p70S6K signaling cascade. Cancer Research, 2015, 75, 2886-96.
14
Venkateswarlu, V.; Balgotra,S.; Vishwakarma, R.A.; Sawant, S.D. Metal-free Chemoselective ortho-C(sp2)–F Bond Hydroxylation and N-trifluoroacylation of Fluoroarylamines for Domino Synthesis of N-trifluoroacyl-ortho-aminophenols. Synlett, 2015, 26, 1258-1262.
15
Guru, S.K.; Venkateswarlu, V.; Malik, F. A.; Sawant, S.D.; Vishwakarma, R.A.; Bhushan, S. A novel quinoline based second-generation mTOR inhibitor that induces apoptosis and disrupts PI3K-Akt-mTOR signaling in human leukemia HL-60 cells. Anti-Cancer Agents in Medicinal Chemistry, 2015, 15, 1297-304. 
16
Manda, S.; Sharma, S.; Wani, A.; Joshi, P.; Kumar, V.; Guru, S.K.; Bharate, S.S.; Bhushan, S.; Vishwakarma, R.A.; Kumar, A. and Bharate, S.B. Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structure-activity relationship.European Journal of Medicinal Chemistry, 2015,107, 1–11.
17
Sharma, Rajni; Vishwakarma, R.A.; Bharate, S.B.An efficient transformation of furano-hydroxychalcones to furanoflavones via base mediated intramolecular tandem O-arylation and C-O bond cleavage: A new approach for synthesis of furanoflavones.Organic & Biomolecular Chemistry, 2015, 13,10461-10465.
18
Baba, S.A.; Mohiuddin, T.; Basu, S.; Swarankar, M.K.; Malik, A.H.; Wani, Z.A.; Singh, A.K.; Ashraf, N. Comprehensive transcriptome analysis of Crocus sativus for discovery and expression of genes involved in apocarotenoid biosynthesis. BMC Genomics, 2015, 16:698. 
19
Yusuf, F.; Rathar, I.A.; Gandhi, S.; Jamwal, U.; Chaubey, A. Cloning and functional characterization of nitrilase from Fusarium proliferatum AUF-2 for detoxification of nitriles. Functional & Integrative Genomics, 2015,15, 413-24.
20
Battini, N.; Battula, S.; Kumar, R.R.; Ahmed, N.Q. 2-Oxo Driven Unconventional reactions: Microwave Assisted Approaches to Tetrahydrofuro[3,2-d]oxazoles and Furanones. Organic Letters, 2015, 17, 2992–2995.
21
Srinivas, M.; Hudwekar, A. D.; Venkateswarlu, V.; Reddy, G. L.; Aravinda, K. A.; Vishwakarma, R. A.; Sawant, S. D. A metal-free approach for transamidation of amides with amines in aqueous media. Tetrahedron Letters, 2015, 56, 4775–4779.  
22
Reddy,K.R.; Reddy,A.S.; Dhaked, D.K.; Rasheed, S.K.; Pathania, A.S.; Shankar, R.; Malik, F.; Das, P. Palladium-catalyzed arylation of 2H-chromene: a new entry to pyrano[2,3-c]carbazoles.  Organic and Biomolecular Chemistry, 2015,13, 9285-9293.
23
Mohammed, S.; Vishwakarma, R.A.; Bharate, S.B. Iodine catalyzed oxidative synthesis of quinazolin-4(3H)-ones and pyrazolo[4,3-d]pyrimidin-7(6H)-ones via amination of sp3 C-H bond. The Journal of Organic Chemistry, 2015, 80, 6915–6921.
24
Yadav, R.R.; Sharma, S.; Joshi, P.; Wani, A.; Vishwakarma, R.A.; Kumar, A.; Bharate, S.B. Meridianin derivatives as potent Dyrk1A inhibitors and neuroprotective agents. Bioorganic and Medicinal Chemistry Letters, 2015, 25, 2948-2952.
25
Yadav, R.R.; Khan, S.I.; Singh, S.; Khan, I.A.; Vishwakarma, R.A.; Bharate, S.B. Synthesis, antimalarial and antitubercular activities of meridianin derivatives. European Journal of Medicinal Chemistry, 2015, 98, 160-169.
26
Sharma, R.; Abbat, S.; Mudududdla, R.; Vishwakarma, R.A.; Bharatam, P.V.; Bharate, S.B. Ortho-quinone methides: TFA-mediated generation in water and trapping with lactams and styrenes. Tetrahedron Letters, 2015, 56, 4057-4059.
27
Bharate, J.B.; Vishwakarma, R.A.; Bharate, S.B. Metal-free domino one-pot protocols for quinoline synthesis. RSC Advances, 2015, 5, 42020-42053.
28
Mupparapua, N.;Vishwakarma, R.A.; Ahmed, N.Q. Iodine-DMSO promoted C–H (SP3) functionalization approach to a-ketoamides. Tetrahedron, 2015, 71, 3417–3421.
29
Padala, A.K.; Mupparapu, N.; Singh, D.; Vishwakarma, R.A.; Ahmed, N.Q. a-Carbonylimine to a-Carbonylamide: An Efficient Oxidative Amidation Approach. European Journal of Organic Chemistry, 2015, 2015, 3577–3586.
30
Rehman, Shakeel-u.; Rah, B.; Lone, S.H.; Rasool, R.U.; Farooq, S.; Nayak, D.;  Chikan, N.A.; Chakraborty, S.; Behl, A.; Mondhe, D.M.; Goswami, A.; Bhat, K.A. Design and Synthesis of Antitumor Heck-Coupled Sclareol Analogues: Modulation of BH3 Family Members by SS-12 in Autophagy and Apoptotic Cell Death. Journal of Medicinal Chemistry, 2015, 58, 3432-44.
31
Khajuria, R.; Kannaboina, P.; Kapoor, K.K.; Gupta, A.; Raina, G.; Jassal, A.K.; Rana, L.K.; Hundal, M.S.; Das, P. Divergent synthesis of 4,6-diarylated pyridin- 2(1H)-ones from chalcones: novel access to 2,4,6-triaryl pyridines. Organic and Biomolecular Chemistry , 2015, 13, 5944-5954.
32
Mahale, S.; Bharate, S.B.; Manda, S.; Joshi, P.; Jenkins, P.; Vishwakarma, R.A.; Chaudhuri, B. Anti-tumour Potential of N-(Biphenyl-2yl)-Tryptoline (BPT): A Dual Inhibitor of Cdk4 and Tubulin Polymerization. Cell death and Disease, 2015, 6, e1743.
33
Rasheed, S.K.; Rao, D.N.; Reddy, A.S.; Shankar, R.; Das, P. Sulphuric acid immobilized on silica gel (H2SO4–SiO2) as an eco-friendly catalyst for transamidation. RSC Adv., 2015,5, 10567-10574.
34
Bharate, J.B.; Singh, S.; Wani, A.; Sharma, S.; Joshi, P.; Khan, I.A.; Kumar, A.; Vishwakarma, R.A.; Bharate, S.B. Discovery of 4-acetyl-3-(4-fluorophenyl)-1-(p-tolyl)-5-methylpyrrole as a dual inhibitor of human P-glycoprotein and Staphylococcus aureus Nor A efflux pump. Organic & Biomolecular Chemistry, 2015, 13(19):5424-31.
35
Singh, B.; Kumar, A.; Joshi, P.; Guru, S.K.; Kumar, S.; Wani, Z.A.; Mahajan, G.; Hussain, A.; Qazi, A.; Kumar, A.; Bharate, S.S.; Gupta, B.D.; Sharma, P.R.; Dar, A.H.; Saxena, A.K.; Mondhe, D.M.; Bhushan, S.; Bharate, S.B.; Vishwakarma, R.A. Design and synthesis of colchicine derivatives with potent in vitro and in vivo anticancer activity and reduced p-glycoprotein induction liability. Organic & Biomolecular Chemistry, 2015,  13, 5674-5689.
36
Bharate, J.B.; Abbat, S.; Sharma, R.; Bharatam, P.V.; Vishwakarma, R.A.; Bharate, S.B. Cobalt (II) catalyzed C(sp)-H bond functionalization of alkynes with phenyl hydrazines: A facile access to diaryl 1,2-diketones. Organic & Biomolecular Chemistry, 2015, 13, 5235-5242.
37
Bharate, J.B.; Batarseh, Y.S.; Wani, A.; Sharma, S.; Vishwakarma, R.A.; Kaddoumi, A.; Kumar, A.; Bharate, S.B. Synthesis and P-glycoprotein induction activity of colupulone analogs. Organic & Biomolecular Chemistry, 2015, 13, 5488-96.
38
Lone, S.H.; Bhat, K.A. Hemisynthesis of a naturally occurring clinically significant antitumor arglabin from ludartin. Tetrahedron Letters, 2015, 56, 1908–1910.
39
Sawant, S.D.; Reddy, G.L.;  Dar, M.I.;  Srinivas, M.; Gupta, G.; Sahu, P.K.; Mahajan, P.; Nargotra, A.; Singh, S.; Sharma, S.C.; Tikoo, M.; Singh, G.; Vishwakarma, R.A.; Syed, S.H. Discovery of Novel Pyrazolopyrimidinone Analogs as Potent Inhibitors of Phosphodiesterase Type-5. Bioorganic & Medicinal Chemistry, 2015, 23, 2121-8.
40
Kumar, S.; Kumar, G.S.; Pathania, A.S.; Manda, S.; Kumar, A.; Bharate, S.B.; Vishwakarma, R.A.; Malik, F.; Bhushan, S. Fascaplysin induces caspase mediated crosstalk between apoptosis and autophagy through the inhibition of PI3K/AKT/mTOR signaling cascade in human leukemia HL-60 cells. Journal of Cellular Biochemistry, 2015, 116, 985-97.
41
Rah, B.; Rasool, R.U.; Nayak, D.; Yousuf, S.K; Mukherjee, D.; Kumar, L.D.; Goswami, A. PAWR-mediated suppression of BCL2 promotes switching of 3-azido withaferin A (3-AWA)-induced autophagy to apoptosis in prostate cancer cells. Autophagy, 2015, 11, 314-31.
42
Raghupathy, R.; Anilkumar, A.A.; Polley, A.; Singh, P.P.; Yadav, M.; Johnson, C.; Suryawanshi, S.; Saikam, V.; Sawant, S.D.; Panda, A.; Guo, Z.; Vishwakarma, R.A.; Rao, M.; Mayor, S. Transbilayer Lipid Interactions Mediate Nanoclustering of Lipid-Anchored Proteins. Cell, 2015, 161,581–594.
43
Sharma, R.; Guru, S.K.; Jain, S.K.; Pathania, A.S.; Vishwakarma, R.A.; Bhushan, S.; Bharate, S.B. 3-(2,6-Dichloro-benzyloxy)-11-oxo-olean-12-ene-29-oic acid, a semisynthetic derivative of glycyrrhetic acid: Synthesis, antiproliferative, apoptotic and anti-angiogenesis activity. Medicinal Chemistry Communications, 2015, 6, 564-575.
44
Mudududdla, R.; Guru, S.K.; Wani, A.; Sharma, S.; Joshi, P.; Vishwakarma, R.A.; Kumar, A.; Bhushan, S.; Bharate, S.B. 3-(Benzo[d][1,3]dioxol-5-ylamino)-N-(4-fluorophenyl)thiophene-2-carboxamide overcomes cancer chemoresistance via inhibition of angiogenesis and P-glycoprotein efflux pump activity. Organic & Biomolecular Chemistry, 2015, 13, 4296-4309.
45
Mohammed, S.; Vishwakarma, R.A.; Bharate, S.B. Metal-free DBU promoted regioselective synthesis of isoxazoles and isoxazolines. RSC Advances, 2015, 5, 3470-3473.
46
Wani, Z.A.; Ashraf, N.; Mohiuddin, T.; S, Riyaz-Ul-Hassan. Plant-endophyte symbiosis, an ecological perspective. Applied Microbiology and Biotechnology, 2015, 99, 2955-65.
47
Kumar,K.A.; Kannaboina, P.; Dhaked, D.K.; Vishwakarma, R.A.; Bharatam, P.V.; Das, P. Cu-catalyzed arylation of the amino group in the indazole ring: regioselective synthesis of pyrazolo-carbazoles. Organic and Biomolecular Chemistry, 2015, 13, 1481-1491.
48
Mupparapu, N.; Battini, N.; Battula, S.; Khan, S.; Vishwakarma, R.A.; Qazi, N.A. Aminocatalytic Cross-Coupling Approach via Iminium Ions to Different C-C Bonds. Chemistry, 2015,21, 2954–2960.
49
Qazi ,A.K.; Hussain, A.; Khan, S.; Aga, M.A.; Behl, A.; Ali, S.; Singh, S.K.; Taneja, S.C.; Shah, B.A.; Saxena, A.K.; Mondhe, D.M.; Hamid, A. Quinazoline based small molecule exerts potent tumour suppressive properties by inhibiting PI3K/Akt/FoxO3a signalling in experimental colon cancer. Cancer Letters, 2015, 359, 47-56.
50
Rather, I.A.; Awasthi, P.; Mahajan, V.; Bedi, Y.S.; Vishwakarma, R.A.; Gandhi , S.G. Molecular cloning and functional characterization of an antifungal PR-5 protein from Ocimum basilicum. Gene, 2015, 558,143-51.
51
Aruri ,H.; Singh, U.; Sharma, S.; Gudup, S.; Bhogal, M.; Kumar, S.; Singh, D.; Gupta, V.K.; Kant, R.; Vishwakarma, R.A.; Singh, P.P. Cross-Dehydrogenative Coupling of Azoles with α-C(sp(3))-H of Ethers and Thioethers under Metal-Free Conditions: Functionalization of H-N Azoles via C-H Activation. Journal of Organic Chemistry, 2015, 8,1929-36.
52
Mehra, R.; Sharma, R.; Khan, I.A.; Nargotra, A. Identification and optimization of Escherichia coli GlmU inhibitors: An in silico approach with validation thereof. European Journal of Medicinal Chemistry, 2015,92,78-90.

Representative Publications During 2014

Top

1
Rana, S.; Bhat, W.; Dhar, N.; Pandith, S.A.; Razdan, S.; Vishwakarma, R.; Lattoo, S.K. Molecular characterization of two A-type P450s, WsCYP98A and WsCYP76A from Withania somnifera (L.) Dunal: expression analysis and withanolide accumulation in response to exogenous elicitations. BMC Biotechnology, 2014, 14(1): 89.
2
Kumar, S.; Pathania, A.S.; Guru, S.K.; Mupparapu, N.; Kumar, A.; Malik, F.; Bharate, S.B.; Qazi, N.A.; Vishwakarma, R.A.; Bhushan, S. A novel quinazolinone derivative induces cytochrome c interdependent apoptosis and autophagy in human leukemia MOLT-4 cells. Toxicology Reports, 2014,1, 1013–1025.
3
Deshidi, R.; Kumar, M.; Devari ,S.; Shah ,B.A. A general metal free approach to a-ketoamides via oxidative amidation–diketonization of terminal alkynes. Chemical Communications, 2014, 50, 9533-9535.
4
Majeed, R.; Hamid, A.; Sangwan, P.L.; Chinthakindi, P.K.; Koul ,S.; Rayees, S.; Singh, G.; Mondhe, D.M.; Mintoo, M.J.; Singh, S.K.; Rath, S.K.; Saxena, A.K. Inhibition of phosphotidylinositol-3 kinase pathway by a novel naphthol derivative of betulinic acid induces cell cycle arrest and apoptosis in cancer cells of different origin. Cell death and Disease, 2014, 5(10): e1459.
5
Rao, D.N.; Rasheed, S.k.; Vishwakarma, R.A.; Das, P. Copper-catalyzed sequential N-arylation of C-amino-NH-azoles. Chemical Communications, 2014, 50, 12911-12914.
6
Mahale, S.; Bharate, S.B.; Manda, S.; Joshi, P.; Bharate, S.S.; Jenkins, P.R.; Vishwakarma, R.A.; Chaudhuri, B.Biphenyl-4-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-methylamide (CA224), a non-planar analog of fascaplysin inhibits Cdk4 and tubulin polymerization: Evaluation of in vitro and in vivo anticancer activity. Journal of Medicinal Chemistry, 2014, 57, 9658-9672.
7
Mudududdla, R.;  Sharma, R.;   Abbat,   S.; Bharatam, P.V.;  Vishwakarma, R.A.; Bharate, S.B. Synthesis of 2-phenylnaphthalenes from styryl-2-methoxybenzenes. Chemical Communications, 2014, 50, 12076-12079.
8
Jain, S.K.; Singh, S.; Khajuria, A.; Guru, S.K.; Joshi, P.; Meena, S.; Nadkarni, J.; Singh, A.; Bharate, S.S.; Bhushan, S.; Bharate, S.B.; Vishwakarma, R.A. Pyrano-isochromanones as IL-6 inhibitors: Synthesis, in-vitro and in-vivo anti-arthritic activity. Journal of Medicinal Chemistry, 2014, 57, 7085−7097.
9
Bharate, J.B.; Bharate, S.B.; Vishwakarma, R.A. Metal-free, ionic liquid-mediated synthesis of functionalized quinolines. ACS Combinatorial Science, 2014, 16, 624–630.
10
Joshi, P.;  Singh,  S.; Wani,  A.; Sharma, S.;  Jain, S.K.;  Singh,  B.; Gupta,  B.; Satti,  N.; Koul, S.;  Khan, I.A.; Kumar, A.;   Bharate, S.B.; Vishwakarma, R.A. Osthol and curcumin as inhibitors of human Pgp and multidrug efflux pumps of Staphylococcus aureus: Reversing the resistance against frontline antibacterial drugs. Medicinal Chemistry Communications, 2014, 5, 1540–1547.
11
Singh, B.; Guru, S.K.; Sharma, R.; Bharate, S.S.; Khan, I.A.; Bhushan, S.; Bharate, S.B.; Vishwkarma, R.A. Synthesis and anti-proliferative activities of new derivatives of embelin. Bioorganic & Medicinal Chemistry Letters, 2014, 24, 4865-4870.
12
Aithagani, S Kumar;   Yempalla, K.R ;  Munagala, G.;  Vishwakarma,R.A.; Singh, P.P. Metal-free, high yielding synthesis of unsymmetrical biaryl, bi(heteroaryl), aryl vinyl, aryl alkyl sulfones via coupling of aryne with sulfinic acid salts. RSC Advances, 2014, 4, 50208-50211.
13
Dara,Saidulu; Varma ,Saikam; Yadav,Mahipal; Singh,Parvinder Pal; and Vishwakarma,Ram A.;.HClO4–silica-catalysed regioselective opening of benzylidene acetals and its application towards regioselective HO-4 glycosylation of benzylidene acetals in one-pot. Carbohydrate Research, 2014, 93–96.
14
Gannedi,V.; Ali, A.;  Singh, P.P; Vishwakarma, R.A. Intramolecular aglycon delivery for (1 → 2)-β-mannosylation: towards the synthesis of phospholipomannan of Candida albicans. Tetrahedron Letters, 2014, 55, 2945-2947
15
Mupparapu, N.; Khan, S.; Battula, S.; Kushwaha, M.; Gupta, A.P.; Ahmed, Q.N.; Vishwakarma, R.A. Metal-Free Oxidative Amidation of 2-Oxoaldehydes: A Facile Access to α-Ketoamides. Organic Letters, 2014, 16 (4), 1152–1155.
16
Dhar, N.; Rana, S.; Razdan, S.; Bhat, W.W.; Hussain, A.; Dhar, R.S.; Vaishnavi, S.; Hamid, A.; Vishwakarma, R.A.; Lattoo, S.K. Cloning and functional characterization of three branch point oxidosqualene cyclases from Withania somnifera (L.) Dunal. The Journal of Biological Chemistry, 2014, 289, 17249-17267.
17
Jain, S.K.; Kumar, K.A.A.; Bharate, S.B.; Vishwakarma, R.A. Facile access to amides and hydroxamic acids directly from nitroarenes. Organic and Biomolecular Chemistry, 2014, 12, 6465-6469.
18
Bhat, W.W.; Rana, S.; Dhar, N.; Razdan, S.; Pandith, S.A.; Vishwakarma, R.A.; Lattoo, S.K. An inducible NADPH-cytochrome P450 reductase from Picrorhiza kurrooa- an imperative redox partner of cytochrome P450 enzymes. Functional and Integrative genomics, 2014, 14(2), 381-399.
19
Venkateswarlu, V.; Kumar, K.A.A.; Balgotra, S.; Reddy, G. L.; Srinivas, M.; Vishwakarma, R. A.;  Sawant, S.D. C-H Oxygenation and N-Trifluoroacylation of Arylamines Under Metal-Free Conditions: A Convenient Approach to 2-Aminophenols and N-Trifluoroacyl-ortho-aminophenols. Chemistry, 2014, 20(22), 6641-5. 
20
Reddy, G. L.; Guru, S. K.;  Srinivas, M.; Pathania, A. S.; Mahajan, P.; Nargotra, A.; Bhushan, S.; . Vishwakarma, R. A.; Sawant, S.D. Synthesis of 5-substituted-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one analogs and their biological evaluation as anticancer agents: mTOR inhibitors. European Journal of Medicinal Chemistry, 201480, 201-8.
21
Bhat, W.W.; Razdan, S.; Rana S.; Dhar, N.; Wani, T.A.; Qazi, P.; Vishwakarma, R.; Lattoo, S.K. A phenylalanine ammonia-lyase ortholog (PkPAL1) from Picrorhiza kurrooa Royle ex. Benth: Molecular cloning, promoter analysis and response to biotic and abiotic elicitors. Gene, 2014, 547(2), 245–256.
22
Mudududdla, R.; Sharma, R.; Guru, S.K.; Kushwaha, M.; Gupta, A.P.; Bharate, S.S.; Aravinda, S.; Kant, R.; Bhushan, S; Vishwakarma, R.A.; Bharate, S.B.Trifluoroacetic acid catalyzed thiophenylmethylation and thioalkylmethylation of lactams and phenols via domino three-component reaction in water. RSC Advances,2014, 2014, 4, 14081-14088.
23
Bharate, J.B.; Wani, A.; Sharma, S.; Reja, S.I.; Kumar, M.; Vishwakarma, R.A.; Kumar, A.; Bharate, S.B. Synthesis, antioxidant, neuroprotective and P-glycoprotein induction activity of 4-arylquinoline-2-carboxylates. Organic and Biomolecular Chemistry, 2014, 12, 6267-6277.
24
Lone, S.H.; Bhat, K.A.; Majeed, R.; Hamid, A. Click chemistry inspired facile synthesis and bioevaluation of novel triazolyl analogs of Ludartin. Bioorganic & Medicinal Chemistry Letters, 2014, 24(4), 1047-1051.
25
Lambu, M.R.; Yousuf, S.; Tripathi, A.K.; Sharma, D.K.; Hussain, A.; Singh, B.; Mukherjee, D. Synthesis of C-spiro-glycoconjugates from sugar lactones via zinc mediated Barbier reaction. RSC Advances, 2014, 4, 11023-11028.
26
Qadri, M.;  Rajput, R.; Abdin, M.Z.,  Vishwakarma, R.A.; Riyaz-Ul-Hassan, S. Diversity, molecular phylogeny and bioactive potential of fungal endophytes associated with the Himalayan blue pine (Pinus wallichiana). Microbial Ecology, 2014, 67(4), 877-887.
27
Hussain, A.; Mukherjee, D. Highly diastereoselective 1,2-dichlorination of glycals using NCS/PPh3: study of substituent and solvent effects. Tetrahedron letters, 2014, 70, 1133-1139.
28
Jain, S.K.; Meena, S.; Gupta, A.P.; Kushwaha, M.; Uma Shaanker, R.; Jaglan, S.; Bharate, S.B.; Vishwakarma, R.A. Dysoxylum binectariferum bark as a new source of anticancer drug camptothecin: Bioactivity-guided isolation and LCMS-based quantification. Bioorganic & Medicinal Chemistry Letters, 2014, 24, 3146-3149.
29
Yadav, M.; Raghupathy, R.; Saikam, V.; Dara, S.; Singh, P.P.; Sawant, S.D.; Mayor, S.;Vishwakarm,R.A. Synthesis of non-hydrolysable mimics of glycosylphosphatidylinositol (GPI) anchors. Organic & Biomolecular Chemistry, 2014, 12, 1163.
30
Sawant, S.D.; Hudwekar, A.D.; Kumar, K.A. Aravinda.; Venkateswarlu, V.; Singh, P.P.; Vishwakarma , R.A. Ligand- and base-free synthesis of phenols by rapid oxidation of arylboronic acids using iron(III) oxide. Tetrahedron letters, 2014, 55, 811–814.
31
Rasheed, Sk. ; Rao, D. N.; Kumar, K. R.; Aravinda, S. ; Vishwakarma, R.A.; Das, P. C-N bond formation via Cu-catalyzed cross coupling with boronic acids leading to methyl carbazole-3-carboxylate: Synthesis of carbazole alkaloids. RSC Advances, 2014, 4, 4960-4969
32
Manda, S.; Khan, S.I.; Jain, S.K.; Mohammed, S.; Tekwani, B.L.; Khan, I.A.; Vishwakarma, R.A.; Bharate, S.B. Synthesis, antileishmanial and antitrypanosomal activities of N-substituted tetrahydro-β-carbolines. Bioorganic & Medicinal Chemistry Letters, 2014, 24, 3247-3250.
33
Shekaraiah, D.; Jaglan, S.; Kumar, M.; Deshidi, R.; Guru, S. ; Bhushan, S.; Kushwaha , M.; Gupta, A.P. ; Gandhi, S.G. ;  Sharma , J. P. ; Taneja , S.C. ; Vishwakarma, R.A. ; Shah , B.A . Capsaicin production by Alternaria alternata, an endophytic fungus from Capsicum annum; LC–ESI–MS/MS analysis, Phytochemistry, 2014, 98, 183–189
34
Chib, R ; Kumar, M.; Rizvi, M.; Sharma, S.; Pandey, A.; Bani, S.; Andotra, S.S.; Taneja, S.C. ; Shah, B. A. Anti-inflammatory terpenoids from Boswellia ovalifoliolata. RSC Advances, 2014, 4, 8632-8637

               Complete list of publications during 2014

Representative Publications During 2013

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1
Ithimakin, S.; Day, K.C.; Malik, F.; Zen, Q.; Dawsey, S.J.; Bersano-Begey, T.F.; Quraishi, A.A.; Ignatoski, K.W.; Daignault, S.; Davis, A.; Hall, C.L.; Palanisamy, N.; Heath, A.N.; Tawakkol, N.; Luther, T.K.; Clouthier, S.G.; Chadwick, W.A.; Day, M.L.; Kleer, C.G.; Thomas, D.G.; Hayes, DF.; Korkaya, H.; Wicha, MS. HER2 drives luminal breast cancer stem cells in the absence of HER2 amplification: Implications for efficacy of adjuvant trastuzumab. Cancer Research, 2013, 73(5):1635-46.          
2
Kumar, S.; Pathania, A.; Guru, S.; Kumar, A.; Bhushan, S.;  Malik, F. Autophagy triggered by Magnolol derivative negatively regulates angiogenesis.(NPG). Cell Death and Disease, 2013, 4, e889.
3
Bharate, S.B.; Sawant, S.D.; Singh, P.P.; Vishwakarma, R.A. Kinase inhibitors of marine origin. Chemical Reviews, 2013, 113, 6761–6815.
4
Lambu, M.R.; Kumar, S.; Yousuf, S.K.; Sharma, D.K.; Hussain, A.; Kumar, A.; Malik, F.; Mukherjee, D. Medicinal Chemistry of dihydropyran based medium ring macrolides related to aspergillides:selective inhibition of PI3K-alpha. Journal of Medicinal Chemistry, 2013, 8;56(15):6122-35.
5
Pathania, A.; Joshi, A.; Kumar, S.; Guru, S.; Bhushan, S.; Sharma, P.; Bhat, W.; Saxena, A.; Singh, J.; Shah, B.; Andotra, S.; Taneja, S.; Malik, F.; Kumar, A. Reversal of boswellic acid analog BA145 induced caspase dependent apoptosis by PI3K inhibitor LY294002 and MEK inhibitor PD98059 Apoptosis,2013, 18:156-73.  
6
Madhubabu, T.; Kusunuru, A.K.; Yousuf , S.K.; Mukherjee ,D. Tandem regio- and diastereo-selective synthesis of halogenated C-vinyl glycosides from unactivated arylacetylenes. Chemical Communications, 2013, 49, 11409-11411.
7
Jain, S.K.; Pathania, A.S.; Meena, S.; Sharma, R.; Sharma, A.; Singh, B.; Gupta, B.D.; Bhushan, S.; Bharate, S.B.; Vishwakarma, R.A. Semisynthesis of Mallotus B from Rottlerin: Evaluation of Cytotoxicity and Apoptosis-inducing Activity, Journal of Natural Products, 2013, 76, 1724−1730.
8
Kumar, A.; Yousuf, S.K.; Mukherjee, D. Copper mediated highly stereoselective synthesis of C-glycosides from unactivated alkynes.Chemical Communications, 2013, 49, 10154-10156.
9
Kannaboina, P ; Kumar, A; Aravinda, S. ; Vishwakarma, R.A.; Das, P. Direct C-2 Arylation of 7-Aza indoles: Chemoselective Access to Multiarylated Derivatives. Organic Letters, 2013, 15, 5718.
10
Bhat, W. W.; Dhar, N.; Razdan, S.; Rana, S.; Mehra, R.; Nargotra, A.; Dhar, R.S.; Ashraf, N.; Vishwakarma, R.A.; Lattoo, S.K. Molecular Characterization of UGT94F2 and UGT86C4, Two Glycosyltransferases from Picrorhiza kurrooa: Comparative Structural Insight and Evaluation of Substrate Recognition. PLoS ONE, 2013, 8(9): e73804.
11
Dhar, N.; Rana, S.; Bhat, W. W.; Razdan, S.; Pandith, S.A.; Khan, S.; Dutt, P.; Dhar, R.S.; Vaishnavi, S.; Vishwakarma, R.; Lattoo, S.K. Dynamics of withanolide biosynthesis in relation to temporal expression pattern of metabolic genes in Withania somnifera (L.) Dunal: a comparative study in two morpho-chemovariants. Molecular Biology Reports, 2013, 40(12):7007-16.
12
Kaur, T.; Hussain, K.; Koul, S.; Vishwakarma, R.; Vyas, D. Evaluation of Nutritional and Antioxidant Status of Lepidium latifolium Linn. A Novel Phytofood from Ladakh. PLoS ONE, 2013, 8(8): e69112. 
13
Singh, P.P.; Aithagani, S.K.; Yadav, M.; Singh, V.P.; Vishwakarma, R.A. Iron-catalyzed Cross-Coupling of Electron-Deficient Heterocycles and Quinone with Organoboron Species via Innate C-H Functionalization: Application in Total Synthesis of Pyrazine Alkaloid Botryllazine A. Journal of Organic Chemistry, 2013,  78, 2639-2648
14
Kumar, M; Qadri, M.; Sharma, P.R.; Kumar, A.; Andotra, S.S.; Kaur ,T.; Kapoor, K,.; Gupta, V.K.; Kant, R.; Hamid, A.; Johri, S.; Taneja, S.C.; Vishwakarma, R.A.; Riyaz-Ul-Hassan, S.; Shah, B.A. Tubulin Inhibitors from an Endophytic Fungus isolated from Cedrus deodara. Journal of Natural Products, 2013, 76(2), 194-199
15
Kumar, S.; Kumar, A.; Pathania, A.S.; Guru, S.K.; Jada, S.; Sampath Kumar, S.M.; Malik, F. Tiron and trolox potentiate the autophagic cell death induced by magnolol analog Ery5 by activation of Bax in HL-60 cells. Apoptosis, 2013, 18(5):605-17.
16
Rana, S.; Lattoo, S.K.; Dhar, N.; Razdan, S.; Bhat, W.W.; Dhar, R.S.; Vishwakarma, R.A. NADPH-Cytochrome P450 reductase: Molecular cloning and functional characterization of two paralogs from Withania somnifera (L.) Dunal.  PLoS ONE, 2013,  8(2), e57068
17
Jain, S.K.; Meena, S.; Qazi, A.K.; Hussain, A.; Bhola, S.K.; Kshirsagar, R.; Pari, K.; Khajuria, A.; Hamid, A.; Uma Shaanker, R.; Bharate, S.B.; Vishwakarma, R.A. Isolation and biological evaluation of chromone alkaloid dysoline, a new regioisomer of rohitukine from Dysoxylum binectariferum. Tetrahedron letters, 2013, 54, 7140-7143.
18
Singh, B.; Guru, S.K.; Kour, S.; Jain, S.K.; Sharma, R.; Sharma, P.R.; Singh, S.; Bhushan, S.; Bharate, S.B.; Vishwakarma, R.A. Synthesis, antiproliferative and apoptosis-inducing activity of thiazolo[5,4-d]pyrimidines. European Journal of Medicinal Chemistry, 2013, 70, 864-874.
19
Bharate, J.B.; Sharma, R.; Singh, B.; Aravinda, S.; Gupta, V.K.; Bharate, S.B.; Vishwakarma, R.A. Montmorillonite clay catalyzed synthesis of functionalized pyrroles through domino four-component coupling of amines, aldehydes, 1,3-dicarbonyl compounds and nitroalkanes. RSC Advances, 2013, 3 (44), 21736-21742.
20
Bharate, J.B.; Guru, S.K.; Jain, S.K.; Meena, S.; Singh, P.P.; Bhushan, S.; Singh, B.; Bharate, S.B.; Vishwakarma, R.A. Cu-Mn spinel oxide catalyzed synthesis of imidazo[1,2-a]pyridines through domino three-component coupling and 5-exo-dig cyclization in water. RSC Advances, 2013, 3 (43), 20869-20876.
21
Bharate, S.B.; Padala, A.; Dar, B.A.; Yadav, R.R.; Singh, B.; Vishwakarma, R.A. Montmorrillonite clay Cu(II) catalyzed domino one-pot multicomponent synthesis of 3,5-disubstituted isoxazoles. Tetrahedron letters, 2013, 54, 3558-3561.
22
Bharate, S.B.; Mudududdla, R.; Sharma, R.; Vishwakarma, R.A. The first method for C-vinylation of aromatic systems.  Tetrahedron letters, 2013, 54, 2913-2915.
23
Bharate, S.B.; Bharate, J.B.; Khan, S.I.; Tekwani, B.L.; Jacobs, M.R.; Mudududdla, R.; Yadav, R.R.; Singh, B.; Sharma, P.R.; Maity, S.; Singh, B.; Khan, I.A.; Vishwakarma, R.A. Discovery of 3,3'-diindolylmethanes as potent antileishmanial agents. European Journal of Medicinal Chemistry, 2013, 63, 435-443.
24
Lone, S.H.; Bhat, K.A.; Naseer, S.; Ratherb, R.A.; Khuroo, M.A.; Tasduq, S.A. Isolation, cytotoxicity evaluation and HPLC-quantification of thechemical constituents from Artemisia amygdalina Decne.  Journal of Chromatography B, 2013, 940(2013) 135– 141.
25
Hussain, A.; L, M.R.; Sharma ,D.K.; Tripathi, A.K.; Singh, B.; Mukherje, D. Synthesis of carbohydrate fused chiral macrocyclic benzolactones through Sonogashira reaction. RSC Advances, 2013, 3, 19899-19904
26
Hussain, A.; Yousuf, S.K.; Kumar, D.; L, Malikharjunrao.; Singh, B.; Mukherjee, D. Design and synthesis of carbohydrate based medium sized sulphur containing benzannulated macrocycles; Applications of Sonogashira and Heck coupling. Tetrahedron Letters, 2013, 69, 5517-5524.
27
Devari, S.; Deshidi, R ; Kumar, M;  Kumar, A.; Sharma, S. ; Rizvi, M;  Kushwaha , M ; Gupta , A.P. ; Shah , B.A. Osmium (VI) catalyzed chemoselective oxidation of allylic and benzylic alcohols. Tetrahedron Letters, 2013, 54(48), 6407–6410.
28
Jain, S.K.; Pathania, A.S.; Parshad, R.; Raina, C.; Ali, A.; Gupta, A.P.; Kushwaha, M.; Aravinda, S.; Bhushan, S.; Bharate, S.B.; Vishwakarma, R.A. Chrysomycins A–C, antileukemic naphthocoumarins from Streptomyces sporoverrucosus. RSC Advances, 2013, 3, 21046-21053.
29
Singh, B.; Parshad, R.; Khajuria, R.K.; Guru, S.K.; Pathania, A.S.; Sharma, R.; Chib, R.; Arvinda, S.; Gupta, V.K.; Khan, I.A.; Bhushan, S.; Bharate, S.B.; Vishwakarma, R.A. Saccharonol B, a new cytotoxic methylated isocoumarin from Saccharomonospora azurea. Tetrahedron Letters, 2013, 54, 6695-6699.
30
Bharate, S.B.; Yadav, R.R.; Khan, S. I.; Tekwani, B. L.; Jacob, M. R.; Khan, I.A.; Vishwakarma, R.A. Meridianin G and its analogs as antimalarial agents. Medicinal Chemistry Communications, 2013,  4, 1042-1048
31
Chaubey, A.; Raina, C.; Parshad, R.; Rouf, A.; Gupta, P.; Taneja, S.C. Bioconversion of sucralose-6-acetate to sucralose using immobilized microbial enzymes. Journal of Molecular Catalysis B: Enzymatic, 2013,  91, 81-86.
32
Ali, A.; Khajuria, A.; Sidiq, T.; Kumar, A.; Thakur, N.L.; Naik, D.; Vishwakarma, R.A. Modulation of LPS induced inflammatory response by Lawsonyl monocyclic terpene from the marine derived Streptomyces sp. Immunology Letters, 2013, 150, 79-86.
33
Kamal, A.; Swapna, P.; Shetti, V.C.R.N.C.R.; Shaik, A.B.; Rao, M.P.N.; Sultana, F.; Khan, I.A.; Sharma, S.; Kalia, N.P.; Kumar, S.; Chandrakant, B. Anti-tubercular agents. Part 7: A new class of diarylpyrrole–oxazolidinone conjugates as antimycobacterial agents. European Journal of Medicinal Chemistry, 2013, 64: 239-251.

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               Complete list of publications during 2013

               Complete list of publications during 2012

               Complete list of publications during 2011