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Publications During 2014

A general metal free approach to a-ketoamides via oxidative amidation–diketonization of terminal alkynes. Chemical Communications, 2014, 50, 9533-9535.
Inhibition of phosphotidylinositol-3 kinase pathway by a novel naphthol derivative of betulinic acid induces cell cycle arrest and apoptosis in cancer cells of different origin.Cell death and Disease, 2014 5(10): e1459.
Copper-catalyzed sequential N-arylation of C-amino-NH-azoles. Chemical Communications, 2014, 50, 12911-12914.
Molecular characterization of two A-type P450s, WsCYP98A and WsCYP76A from Withania somnifera (L.) Dunal: expression analysis and withanolide accumulation in response to exogenous elicitations. BMC Biotechnology, 2014, 14-89.
Biphenyl-4-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-methylamide (CA224), a non-planar analog of fascaplysin inhibits Cdk4 and tubulin polymerization: Evaluation of in vitro and in vivo anticancer activity. Journal of Medicinal Chemistry, 2014, 57, 9658-9672.
Synthesis of 2-phenylnaphthalenes from styryl-2-methoxybenzenes. Chemical Communications, 2014, 50, 12076-12079.
Pyrano-isochromanones as IL-6 inhibitors: Synthesis, in-vitro and in-vivo anti-arthritic activity. Journal of Medicinal Chemistry, 2014, 57, 7085−7097.
Metal-free, high yielding synthesis of unsymmetrical biaryl, bi(heteroaryl), aryl vinyl, aryl alkyl sulfones via coupling of aryne with sulfinic acid salts. RSC Advances, 2014, 4, 50208-50211.
HClO4–silica-catalysed regioselective opening of benzylidene acetals and its application towards regioselective HO-4 glycosylation of benzylidene acetals in one-pot. Carbohydrate Research, 2014, 93–96.
Intramolecular aglycon delivery for (1 → 2)-β-mannosylation: towards the synthesis of phospholipomannan of Candida albicans. Tetrahedron Letters, 2014, 55, 2945-2947
Metal-Free Oxidative Amidation of 2-Oxoaldehydes: A Facile Access to α-Ketoamides. Organic Letters, 2014, 16 (4), 1152–1155.
Cloning and functional characterization of three branch point oxidosqualene cyclases from Withania somnifera (L.) Dunal. The Journal of Biological Chemistry, 2014, 289, 17249-17267.
Facile access to amides and hydroxamic acids directly from nitroarenes. Organic and Biomolecular Chemistry, 2014, 12, 6465-6469.
An inducible NADPH-cytochrome P450 reductase from Picrorhiza kurrooa- an imperative redox partner of cytochrome P450 enzymes. Functional and Integrative genomics, 2014, 14(2), 381-399.
C-H Oxygenation and N-Trifluoroacylation of Arylamines Under Metal-Free Conditions: A Convenient Approach to 2-Aminophenols and N-Trifluoroacyl-ortho-aminophenols. Chemistry2014, 20(22), 6641-5. 
Synthesis of 5-substituted-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one analogs and their biological evaluation as anticancer agents: mTOR inhibitors. European Journal of Medicinal Chemistry, 201480, 201-8.
A phenylalanine ammonia-lyase ortholog (PkPAL1) from Picrorhiza kurrooa Royle ex. Benth: Molecular cloning, promoter analysis and response to biotic and abiotic elicitors. Gene, 2014, 547(2), 245–256.
Trifluoroacetic acid catalyzed thiophenylmethylation and thioalkylmethylation of lactams and phenols via domino three-component reaction in water.RSC Advances,2014, 2014, 4, 14081-14088.
Synthesis, antioxidant, neuroprotective and P-glycoprotein induction activity of 4-arylquinoline-2-carboxylates. Organic and Biomolecular Chemistry, 2014, 12, 6267-6277.
Click chemistry inspired facile synthesis and bioevaluation of novel triazolyl analogs of Ludartin. Bioorganic & Medicinal Chemistry Letters, 2014, 24(4), 1047-1051.
Diversity, molecular phylogeny and bioactive potential of fungal endophytes associated with the Himalayan blue pine (Pinus wallichiana). Microbial Ecology, 2014, 67(4), 877-887.
Highly diastereoselective 1,2-dichlorination of glycals using NCS/PPh3: study of substituent and solvent effects. Tetrahedron letters, 2014, 70, 1133-1139.
Dysoxylum binectariferum bark as a new source of anticancer drug camptothecin: Bioactivity-guided isolation and LCMS-based quantification. Bioorganic & Medicinal Chemistry Letters, 2014, 24, 3146-3149.
Synthesis of non-hydrolysable mimics of glycosylphosphatidylinositol (GPI) anchors. Organic & Biomolecular Chemistry, 2014, 12, 1163-1172.
Ligand- and base-free synthesis of phenols by rapid oxidation of arylboronic acids using iron(III) oxide. Tetrahedron letters, 2014, 55, 811–814.
C-N bond formation via Cu-catalyzed cross coupling with boronic acids leading to methyl carbazole-3-carboxylate: Synthesis of carbazole alkaloids. RSC Advances, 2014, 4, 4960-4969
Synthesis, antileishmanial and antitrypanosomal activities of N-substituted tetrahydro-β-carbolines. Bioorganic & Medicinal Chemistry Letters, 2014, 24, 3247-3250.
Capsaicin production by Alternaria alternata, an endophytic fungus from Capsicum annum; LC–ESI–MS/MS analysis, Phytochemistry, 2014, 98, 183–189
Anti-inflammatory terpenoids from Boswellia ovalifoliolata. RSC Advances, 2014, 4, 8632-8637
Oxidative stress mediated Ca2 release manifests ER stress leading to the UPR in UV-B irradiated human skin cells.Journal of Dermatological Sciences, 2014, 75, 24–35.
Cytotoxin and antimicrobial activities of endophytic fungi isolated from Bacopa monnieri (L) pennels (Scrophilariaceae).BMC Complementary and Alternative Medicine, 2014, 14:52
Synthesis, characterization and mechanistic-insight into the anti-proliferative potential of PLGA-gemcitabine conjugate. The International Journal of Pharmaceutics, 2014, 470,51–62.
A converent synthesis of alkyne-Azide Cyclo addition derivatives of 4ab-2-propyne podophyllotoxin defecting potent cytotoxic activity.European Journal and Medicinal Chemistry,2014, 77, 47–55.
Microwave assisted synthesis a 5-substituted-1H-Pyrazolo [4,3-d] pyrimidine of (6H)-one analogs and their biological evaluation as anticancer agents.European Journal and Medicinal Chemistry,2014,80,201-8. 
Heterogeneous reusable catalyst ultrasound energy and no solvent : a quick and green receipe for one pot synthesis of B-phosphonomalomtes at room temperature.Tetrahedron Letters ,2014, 55, 623-628.
Biodegradable polymeric system for cisplatin delivery: Development, in vitro characterisation and investigation of toxicity profile.Materials Science and Engineering C, 2014,38, 85-93. 
Metal free Steveoselective synthesis of functionalized enamides.Organic & Biomolecular Chemistry,2014, 12, 242-6. 
Synthesis and biological evaluation of substituted N-alkylphenyl-3,5-dinitrobenzamide analogs as anti-TB agents.Medicinal Chemistry Communications, 2014,5, 521-527.
Quantification of anticancer polyisoprenylated benzophenones garcinol and isogarcinol using multiple reaction monitoring LC-ESI-MS-MS in ultrasound assisted extracts of Garcinia indica fruits. Journal of AOAC International, 2014, 97,1317-1322.
Isolation, identification and simultanoeus quantification of five major flavonoids of Epimedium elatum by High Performance Liquid Chromatography. Journal of Liquid Chromatography and related Technologies, 2014, 37, 1104-1113.
Retrotransposon based genetic status of North-West Himalayan Zingiber officinale revealed high heterogeneity. Journal of Plant Biochemistry and Biotechnology,2014, 23, 211-216.
Structural Characterisation of Bacillus subtitic membrane protein Binr: an insilico approach.Current Computer Aided Drug Design, 2014,10,226-36.
Pharmacokinetic study of Piperine in Wistar rats after oral and intravenous administration.International Journal of drug delivery,2014, 6, 82-87.
Synthesis of C-spiro glyco conjugates from sugar lactones via Zinc mediated Barbies reaction.RSC Advances ,2014 ,4(22),11023-11028.
Endophytic fungi found in association with Bacopa monnieri as resourceful producers of industrial enzymes and antimicrobial bioactive natural products. Brazilian Archives of Biology and Technology, 2014, 57, 714-722.
Vasicine as tridentate Ligand for Enantioselective addition of Diethyl Zinc to Aldehydes.Tetrahedron Letters,2014, 55, 2639–2641.
A novel Quinazolinone derivative induce cytochrome with interpendent apoptosis and utophagy in human leukemia MOLT-4 cells.Toxicology Reports ,2014, 1,1013–1025.
New Biflavonoids from the roots of Scutellaria prostrata. Fitoterapia, 2014, 28,1685-1690.
Identifying and Developing leadership skills for the next generation library Directors in the information environment. European Academic Research,2014, I
A concise synthesis of Hagen's gland lactones.Tetrahedron Letters, 2014,55, 3610–3612.
Osthol and curcumin as inhibitors of human Pgp and Nor A efflux pump of Staphylococcus aureus: Reversing the resistance against frontline antibacterial drugs. Med. Chem. Commun., 2014,5, 1540-1547.
Synthesis and anti-proliferative activities of new derivatives of embelin. Bioorganic & Medicinal Chemistry Letters,2014, 24, 4865–4870.
Metal-free, ionic liquid-mediated C-C/C-N bond formation and C-C- bond cleavage: Synthesis of functionalized quinolines from anilines and aldehydes. ACS Combinatorial Science ,2014,16,624-630.
Cu-Benzotriazole catalyzed Electrophilic cyclization of N-Arylimines: A Methodical Tandem approach to O-protected-4-hydroxyquinazolines.RSC Adv., 2014, 4, 38375-38378.
Hepatoprotective activity of LC-ESI-MS standardised Iris Spuria rhizome extract on its main bioactive constituents.Phytomedicine, 2014,21,1202–1207.
Synthesis of heteroaryl/aryl Kojic acid conjugate as stimulator of gucose uptake by GLUT4 translocation. European Journal of Medicinal Chemistry, 2014, 85, 727–736.
Synthetic modification of hydroxychavicol by Mannich reaction and alkyne-Azide Cyclo addition derivatives depicting cytotoxic potential. European Journal of Medicinal Chemistry,2014, 92, 236–245.
Targeted drug delivery systems for pancreatic cancer. The Journal of Biomedical Nanotechnology, 2014, 10, 3462-3482.
Co-formulation of P-glycoprotein substrate and inhibitor in Nanocarriers: An Emerging Strategy for cancer chemotherapy.Current Cancer Drug Targets, 2014,14, 419-433.
Paclitaxel formulations; Challenges and Novel Delivery options.Current Drug Delivery,2014, 11,666-686.
Advances in p-glycoprotein based approaches for delivering anticancer drugs: pharmacokinetic perspective and clinical relevance. Expert Opinion on Drug Delivery, 2014,11,121-138.