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Publications During 2012

A Synthetic Recursive “+1” Pathway for Carbon Chain Elongation. ACS Chemical Biology, 2012,7,689–697.   
New method for C-H arylation/alkylation at α-position of cyclic aliphatic ethers by iron-oxide mediated reaction.Organic & Biomolecular Chemistry, 2012,10,1587-1597.
An endophyticNodulisporiumsp. producing volatile organic compounds having bioactivity and fuel potential. Journal of Petroleum and Environmental Biotechnology, 2012,4(6),2157-7463.
Molecular cloning, bacterial expression and promoter analysis of squalene synthase from Withaniasomnifera. Gene, 2012,499(1), 25–36.
A Comprehensive Analysis of fifteen genes of steviol glycosides biosynthesis pathway in Stevia rebaudiana. Gene, 2012,492,276-284.
Podophyllumhexandrum aqueous extract as a potential free radical  scavenger. Redox  Report, 2012,17(2),54-62.
Metabolic shift from secondary metabolite productionto induction of anti-oxidative enzymes during NaClstressinSwertiachirata. Acta Physiologiae Plantarum, 2012,34,541–546.
Modulation of volatile organic compound formation in the Mycodiesel® producing endophyte- Hypoxylonsp. Microbiology2012,158,465–473.
Purification and characterization of a cold active alkaline protease from Stenotrophomonas sp., isolated from Kashmir, India World.J MicrobiolBiotechnol, 2012,28,1071–1079.
An efficient plant regeneration via directorganogenesis and Agrobacterium tumefaciens-ediated genetic transformation ofPicrorhizakurrooa - an endangered medicinal herb of alpine Himalayas. In Vitro Cell. Dev. Biol.-Plant, 2012,48(3), 295-303.
Genetic variability studies for morphological and qualitative attributes among Jatrophacurcas L. accessions grown under subtropical conditions of North India .RamSouth AfricanJournal of Botany 2012,79, 102–105.
Reproductive behaviour and breeding system of wild and cultivated types of Withaniasomnifera(L.) Journal of Medicinal Plants Research 2012,6(5):754–762.
Facile synthesis of various 4-carboxylicacid derivatives and their amide analogues of benzopyran. Indian Journal of Chemistry,2012, 51B(04),605-610.
Identification and chracaterization of protein composition in Withaniasomnifera –an Indian ginseng. Journal of Plant Biochemistry and Biotechnology, 2012, 21(1): 77–87.
Variation in the Composition of the Essential Oils of RosmarinusofficinalisL.Grown in Sub-Tropical Region of Jammu and Temperate Region of Kashmir, India. Asian Journal of Chemistry, 2012,(25),2799-2801.
Immunomodulatory studies of a bioactive fraction from the fruit of Prunuscerasus in BALB/c mice. International Immunopharmacology, 2012,12(4):626-34.
Alcohol-associated folatedisturnances result in altered methylation of folate-regulating genes.Molecular and Cellular Biochemistry ,2012,363,157-166.
One-pot synthesis of flavans by recyclable silica-HClO4 catalyzed knoevenagel condensation and [4+2]-Diel’s-Alder cycloaddition. Organic & Biomolecular Chemistry, 2012, 10(26):5143-50.
QSAR and pharmacophore modeling of N-acetyl-2-aminobenzothiazole class of phosphoinositide-3-kinase-alpha inhibitors. Medicinal Chemistry Research, 2012,12, 890-899.
The hydroalcoholic extract of Cassia alata (Linn.) leaves and its major compound rhein exhibits antiallergic activity via mast cell stabilization and lipoxygenase inhibition. Journal of Ethnopharmacology, 2012,141,469-473.
Deformylation of indole and azaindole-3-carboxaldehydes using anthranilamide and solid acid heterogeneous catalyst via quinazolinone intermediate.Tetrahedron Letters, 2012, 53, 2222-2225.
Modulation of k-Ras signaling by natural products .Current Medicinal Chemistry, 2012,19 ,2273-2291 .
Meridianins: A potent marine derived kinase inhibitors. Mini Reviews in Medicinal Chemistry, 2012,12 ,618-631 .
Cyclin-dependent kinase inhibition by flavoalkaloids. Mini Reviews in Medicinal Chemistry, 2012,12(7),632-649.
Chemistry and biology of fascaplysin, a potent marine-derived CDK-4 inhibitor. Mini Reviews in Medicinal Chemistry,2012,12(7),650-664.
Molecular characterization and promoter analysis of squalene epoxidase gene from Withania somnifera (L.) Dunal. Molecular Biology Reports ,2012,40,905–916.
A 12-deoxywithastramonolide-rich somaclonal variant in Withania somnifera (L.) Dunal – molecular cytogenetic analysis and significance as a chemotypic resource .In Vitro Cellular & Developmental Biology - Plant ,2012,48,546–554.
An efficient plant regeneration via direct organogenesis and Agrobacterium tumefaciens-mediated genetic transformation of Picrorhiza kurrooa - an endangered medicinal herb of alpine Himalayas. In Vitro Cellular & Developmental Biology - Plant, 2012,48 (3), 295-303. 
Immobilization of enantioselective lipase on soluble supports for kinetic resolution of drug intermediates. Journal of Bioactive and Compatible Polymers, 2012,27, 499-509.
Engineering Synthetic Recursive Pathways.Nature Chemical Biology, 2012,8 ,518-526 .
Capsaicin, a novel inhibitor of the NorA efflux pump, reduces the intracellular invasion of Staphylococcus aureus.Journal of Antimicrobial Chemotherapy, 2012,67,2401-2408.
Design and synthesis of novel N,N′-glycoside derivatives of 3,3′-diindolylmethanes as potential antiproliferative agents.Medicinal Chemistry Communications, 2012,3,1082-1091.
A Comprehensive Analysis of fifteen genes of steviol glycosides biosynthesis pathway in Stevia rebaudiana (Bertoni). Gene, 2012, 492(1), 276-284
Chromolithic Method Development, Validation and System Suitability Analysis of Ultra-Sound Assisted Extraction of Glycyrrhizic Acid and Glycyrrhetinic Acid from Glycyrrhiza glabra. Natural Product Communications, 2012,7 ,991 – 994 .
Immunomodulatory studies of a bioactive fraction from the fruit of Prunus cerasus in BALB/c mice.International Immunopharmacology, 2012,12,626-634.
2,4,6-Trichloro-1,3,5-triazine (TCT) mediated one-pot sequential functionalisation of glycosides for the generation of orthogonally protected monosaccharide building blocks. Organic & Biomolecular Chemistry, 2012,10,5357-5360.
Regioselective azidotrimethylsilylation of carbohydrates and applications thereof. Organic & Biomolecular Chemistry,2012,10,9090-9098 .
Intramolecular Base-Free Sonogashira Reaction for the Synthesis of Benzannulated Chiral Macrocycles Embedded in Carbohydrate Templates. Advanced Synthesis & Catalysis, 2012,354,1933–1940.
A Novel MMP-2 Inhibitor 3-azidowithaferin A (3-azidoWA) Abrogates Cancer Cell Invasion and Angiogenesis by Modulating Extracellular Par-4. PLoS ONE, 2012, 7(9).
Design and synthesis of novel magnolol derivatives as potential antimicrobial and antiproliferative compounds. European Journal of Medicinal Chemistry , 2012, 51,1-300.
4-epi-Pimaric acid: A phytomolecule as a potent antibacterial and anti–biofilm agent for oral cavity pathogens. European Journal of Clinical Microbiology and Infectious Diseases, 2012,31,149-159.
Chemoenzymatic synthesis of piperoxan,prosympal,dibozane and doxazosin. Tetrahedron: Asymmetry ,2012,23, 1615–1623.
Isolation, production and application of lipase /estrase from Bacillus sp. strain DVL43. Journal of Microbiology and Biotechnology,2012,2(4): 521-525 .
Screening, isolation and production of lipase /esterase producing Bacillus sp. strain DVL2 and its potential evaluation in estrification and resolution. Archives of Applied Science Research,2012,4(4): 1763-1770.
Identification of novel single nucleotide polymorphisms in the DGAT1 gene of buffaloes by PCR-SSCP.Genetics and Molecular Biology, 2012,35(3),610-3.
Synthesis, antimicrobial and cytotoxicity study of 1,3-disubstituted-1H-naphtho[1,2-e][1,3]oxazines. European Journal of Medicinal Chemistry, 2012,56,195-202.
Cu-Mn spinel oxide catalyzed regio-selective halogenation of phenols and N-heteroarenes. Journal of Organic Chemistry, 2012, 77, 5823−5828.
New method for C-H arylation/alkylation at α-position of cyclic aliphatic ethers by iron-oxide mediated reaction.Organic & Biomolecular Chemistry, 2012, 10, 1587-1597.
One-pot multicomponent synthesis of medicinally important purine quinazolinone derivatives. Tetrahedron Letters, 2012, 53, 6195-6198.
Activation of an IL6 Inflammatory Loop Mediates Trastuzumab Resistance in HER2+ Breast Cancer by Expanding the Cancer Stem Cell Population.Molecular Cell, 2012,47, 570–584 .
Breast Cancer Heterogeneity: Need to Review Current Treatment Strategies.Current Breast Cancer Reports, 2012,4,225–231.
Lin28 and HER2: two stem cell regulators conspire to drive aggressive breast cancer.Cell Cycle , 2012,11,2780-1 .
A novel cyano derivative of 11-keto-β-boswellic acid causes apoptotic death by disrupting PI3K/AKT/Hsp-90 cascade, mitochondrial integrity, and other cell survival signaling events in HL-60 cells.Molecular Carcinogenesis, 2012,51(9),679-95 .
Extraction efficiency studies of Podophyllum hexandrum using conventional & non conventional extraction methods by using HPLC –UV –DAD Method. Journal of Liquid Chromatography & Related Technologies,2012.
Ortho-Amidoalkylation of phenols via tandem one-pot approach involving oxazine intermediate. The Journal of Organic Chemistry ,2012,77,8821-8827.
Catalyst-free ipso-nitration of aryl boronic acids using bismuth nitrate.Tetrahedron Letters, 2012,53 (44), 5958-5960.
Total synthesis and anti-cholinesterase activity of marine-derived bis-indole alkaloid fascaplysin. Medicinal Chemistry Communication, 2012,3, 1098-1103.
Tandem one-pot synthesis of flavans by recyclable silica-HClO4 catalyzed knoevenagel condensation and [4+2]-Diel’s-Alder cycloaddition.Organic & Biomolecular Chemistry,2012,10, 5143–5150.
The hydroalcoholic extract of Cassia alata (Linn.) leaves and its major compound rhein exhibits antiallergic activity via mast cell stabilization and lipoxygenase inhibition.Journal of Ethnopharmacology,2012,141, 469-473. 
Deformylation of indole and azaindole-3-carboxaldehydes using anthranilamide and solid acid heterogeneous catalyst via quinazolinone intermediate.Tetrahedron Letters ,2012,53, 2222-2225.
Modulation of k-Ras signaling by natural products. Current Medicinal Chemistry, 2012,19 (14), 2273-2291.  
Meridianins: A potent marine derived kinase inhibitors. Mini Reviews in Medicinal Chemistry, 2012,12 (7), 618-631.
Cyclin-dependent kinase inhibition by flavoalkaloids.Mini Reviews in Medicinal Chemistry, 2012,12 (7), 632-649.
Chemistry and biology of fascaplysin, a potent marine-derived CDK-4 inhibitor. Mini Reviews in Medicinal Chemistry,2012,12 (7), 650-664.
Modulation of TRPM8 by cooling compounds. ACS Chemical Neuroscience, 2012,3 (4), 248–267.
Efficient synthesis of 2,3-dihydroquinazolin-4(1H)-ones using heterogeneous solid acid catalysts: unexpected formation of 2,3-dihydro-2-(4-(tetrahydro-2H-pyran-2-yloxy)butyl)quinazolin-4(1H)-one. ARKIVOC, 2012,8,308-318 .
KF/alumina catalyzed regioselective benzylation and benzoylation using solvent-free grind-stone chemistry. Royal Society of Chemistry,2012,2, 8929-8933.  
Glycyrrhizic acid (GA), a triterpenoid saponin glycoside alleviates ultraviolet-B irradiation-induced photoaging in human dermal
fibroblasts. Phytomedicine, 2012,19(7),658-64.
Bakuchiol derivatives as novel and potent cytotoxic agents.European Journal of Medicinal Chemistry, 2012,49,55-67. 
CuCN catalyzed one pot synthesis of γ-keto diesters: domino double Michael addition followed by Nef reaction.Tetrahedron Letters,2012,53,3305-3309.
Acute,sub-acute and general pharmacology evaluation of 5-(3,4-methylenedioxyphenyl)-4-   ethyl-2E,4E-pentadienoic acid piperidide (Sk-20): a novel drug availability enhancer.Environmental Toxicology and Pharmacology,2012,35(2), 347–359.
Pro-apoptatic properties of parthenin analogs: a quantitative structure-activity relationship study.Medicinal Chemistry Research,2012.
Acylated flavonol glycosides from Epimedium elatum, a plant endemic to the Western Himalayas.Fitoterapia,2012,83,665-670.
Nor triterpenoids from the roots of Paeonia emodi. Phytochemistry Letters, 2012,5(2), 253–257.
Comparative GC-FID and GC-MS Analysis of the Leaf, Stem and Root Essential oils of Artemisia dracunculus. L Growing in Kashmir (India).Journal of Pharmacy Researchm, 2012,2,1353-1356.
Chemical composition of essential oil of Rhododendron lepidotum wall.ex D. Don growing in Kashmir Himalayas. Journal of Essential Oil Research, 2012,23(6) ,25- 28.
Essential oil composition of Nepeta raphanorhiza Benth growing in Kashmir Valley. Records of Natural Products, 2012,6(1),67-70.
Variation in the Composition of the Essential Oils of Rosmarinus officinalis L. grown in Sub-Tropical Region of Jammu and Temperate Region of Kashmir, India.Asian Journal of Chemistry, 2012,24(6),2799-2801.
In vitro cytotoxicity of an endophytic fungus isolated from Nothapodytes foetida. Annals of Microbiology, 2012,59(1),157-161.
Purification and characterization of a cold active alkaline protease from Stenotrophomonas sp., isolated from Kashmir, India World.Journal of Microbiology and Biotechnology, 2012,28(3)1071–1079.
Antibacterial and phytochemical screening of different extracts of five Iris species growing in Kashmir.Journal of Pharmacy Research,2012, 5(6), 3376-3378. 
PARP cleavage and perturbance in mitochondrial membrane  potential by 3-α-propionyloxy-β-boswellic acid results in cancer cell death and tumor regression in  murine models.Future Oncology,2012,8(7), 867-881.
Alcohol associated folate disturbances results in altered methylation of folate regulating genes.Molecular and Cellular Biochemistry,2012,363,157–166.
Acyl derivatives of Boswellic acids as inhibitors of NF-κB and STATs.Bioorganic & Medicinal Chemistry Letters,2012,22,431–435.
Understanding histone deacetylases in the cancer development and treatment: An epigenetic perspective of cancer chemotherapy.DNA and Cell Biology,2012,62-71.
Podophyllum hexandrum aqueous extract as a potential free radical scavenger.Redox Report,2012,17(2),54-62.
Identification and characterization of protein composition in Withania somnifera-An Indian Ginsing.Journal of Plant Biochemistry and Biotechnology,2012, 21(1) 77-87.
Recyclable clay supported Cu (II) catalyzed tandem one-pot synthesis of 1-aryl-1,2,3-triazoles.Tetrahedron,2012, 68, 8156-8162.
Therapeutic targeting of cancer cell metabolism: role of metabolic enzymes, oncogenes and tumor suppressor genes.Journal of Cancer Science & Therapy ,2012, 4(9), 281-291.
Capsaicin a novel inhibitor of NorA efflux pump reduces the intracellular invasion of S. aureus. Journal of Antimicrobial Chemotherapy, 2012; 67, 2401 –2408 .
Immobilization of enantioselective lipase on soluble supports for kinetic resolution of drug intermediates. Journal of Bioactive and compatible polymers, 2012.
Novel thermostable lipase from Bacillus circulans IIIB153: comparison with the mesostable homologue at sequence and structure level. World J MicrobiolBiotechnol, 2012,28(1):193-203.
One- pot Multicomponent synthesis of medicinally important purine Quinazolinone derivatives. Tetrahedron Letters, 2012,53(46), 6195–6198.