Dr. Payare Lal Sangwan

Bio-organic Chemistry Division
CSIR - Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: plsangwan@iim.res.in , plsangwan@iim.ac.in.

Positions Held  
Position Held Date Organization
Senior Scientist 2013 - Present CSIR-IIIM
Scientist 2009 - 2013 CSIR-IIIM
Jr. Scientist 2006 - 2009 CSIR-IIIM
Honours & Awards  
  • Dr. P.D. Sethi Annual Award-2011, Best Research Paper, J. Sep. Sci. 34, 749-760, (2011)

  • Assistant Professor in the faculty of Chemical Sciences (AcSIR)

  • Best poster presentation award at Chemical Research Society of India meeting, Sept., 2011

  • Most downloaded Article, Eur. J. Med. Chem.  2010, 45:3125-34

  • Best Poster presentation award at ASOMPS-XIII, Nov. 2008

  • Recognized PhD Supervisor at AcSIR, GNDU Amritsar, SMVDU Katra and Kashmir University Srinagar

  • Best paper award of institute years, 2008, 2010, 2011, 2012

Membership  
  • Life Member, Indian Science Congress Association, Kolkata India

  • Recognized PhD Supervisor at AcSIR, GNDU Amritsar, SMVDU Katra and Kashmir University Srinagar.

  • Reviewer of Science Direct, ACS Journal

  • Member, American Chemical Society

Research

Discovery and development of bioactive natural products mainly from plant source, enhancement of the prospect of plant secondary metabolites for their commercialization through isolation, analogues preparation and their value addition. Bio-prospection of medicinal as well as chemically or/and pharmacologically unexplored/less explored high altitude/medicinal plants mainly from the western Himalaya regions along with cold/hot desert plants. Chemical characterization of secondary metabolites through spectroscopic especially 2D NMR techniques.

Structural modification of natural products to carry out structure activity relationship (SAR) for pharmacological activities i.e. Anti-cancer, Anti-infective, Immunosuppressive, efflux pumps inhibitors and anti-oxidant etc. Dereplication of Natural products using analytical (spectroscopic, chromatographic) and modern hyphenated techniques. Further development of new and environmental friendly methodology for organic molecules and industrial process chemistry as well as synthesis of novel bioactive scaffold.

Publications
  • Majeed, R.; Hussain ,A.; Hamid, A.;Sangwan ,P.L.;Chinthakindi ,P.K.; Khan, I.;Sharma ,P.R.; Koul, S. ; Saxena ,AK. PI3K target based novel cyano derivative of betulinic acid induces its signalling inhibition by down-regulation of pGSK3β and cyclin D1 and potentially checks cancer cell proliferation. Molecular carcinogenesis (2015) In Press

  • Dar ,A.A.; Sangwan, P.L.; Khan, I.;  Gupta, N.; Qaudri ,A.; Tasduq ,S.A.; Kitchlu, S.; Sharma, A.K.; Koul ,S. Simultaneous quantification of eight bioactive secondary metabolites from Codonopsis ovata by validated high performance thin layer chromatography and their antioxidant profile.J Pharma Biomed. Anal. (2014) 100:300-308.

  • Majeed ,R.; Hamid, A.; Sangwan ,P.L.; Chinthakindi, P.K.; Koul ,S.; Rayees ,S; Singh, G, Mondhe, D.M., Mintoo ,M.J., Singh ,S.K., Rath ,S K , ; Saxena ,AK. Inhibition of phosphotidylinositol-3 kinase pathway by a novel naphthol derivative of betulinic acid induces cell cycle arrest and apoptosis in cancer cells of different origin.Cell Death and Disease(2014) 5, e1459.

  • Farooq ,S.; Rehman, S.; Dangroo, N.A., Priya ,D.; Banday J.A.; Sangwan P.L.; Qurishi M.A.;Koul S.; Saxena A.K. Isolation, cytotoxicity evaluation and HPLC-quantification of the chemical constituents from Prangos pabularia. PLOS ONE(2014)9(10), e108713.

  • Khan, I.; Sangwan, P.L.; Dar, A.A.; Rafiq, R.A.; Farrukh, M.R.; Dhar, J.K.; Tasduq, S.A.; Koul, S. A validated high-performance thin-layer chromatography method for the identification and simultaneous quantification of six markers from Platanus orientalis and their cytotoxic profiles against skin cancer cell lines. J Sep Sci. (2013), 36(16), 2602-10.

  • Majeed, R.; Sangwan, P.L. ; Chinthakindi, P.K.; Khan, I.; Dangaroo, N.A.; Thota, N.; Hamid, A.; Sharma, P.R.; Saxena, A.K.; Koul, S. Synthesis of 3-O-propargylated betulinic acid and its 1,2,3-triazoles as potential apoptotic agents. Eur J Med Chem. (2013), 63, 782-92.

  • Chinthakindi, P.K.; Sangwan, P.L. ; Farooq, S.; Aleti, R.R.; Kaul, A.; Saxena, A.K.; Murthy, Y.L.N.; Vishwakarma, R.A.; Koul, S. Diminutive effect on T and B - cell proliferation of non cytotoxic α-santonin derived 1,2,3-triazoles: A report. Eur J Med Chem(2013), 60, 365-375.

  • Khan I., Sangwan P.L., Dhar J.K. and KoulS. Simultaneous quantification of five marker compounds of Betula utilis stem bark using a validated HPTLC. J. Sep. Sci. 2012, 35, 392-399.

  • Farooq, S.; Sangwan, P.L. ; Aleti, R.R.; Chinthakindi, P.K.; Qurishi, M.A.;  Koul, S.CuCN catalyzed one pot synthesis of γ-keto diesters: domino double Michael addition followed by Nef reaction. Tetrahedron Lett. (2012), 53, 3305-3309.

  • Majeed, R.; Reddy, M.V.; Chinthakindi, P.K.; Sangwan, P.L.; Hamid, A.; Sharma, Chashoo, G.; Saxena, A.K.; Koul, S. Bakuchiol derivatives as novel and potent cytotoxic agents: A report. Eur J Med Chem. (2012), 49, 55-67.

  • Ali, F.; Sangwan, P.L.; Koul, S.; Pandey, A.; Bani, S.; Abdullah, S.T.; Sharma, P.R.; Kitchlu, S.; Khan, I.A. 4-epi-Pimaric acid: a phytomolecule as a potent antibacterial and anti-biofilm agent for oral cavity pathogens. Eur J Clin Microbiol Infect Dis. (2012), 31, 149-159.

  • Khan, I.; Sangwan, P.L.; Abdullah, S.T.; Gupta, B.D.; Dhar, J.K.; Manickavasagar, R.; Koul,S. Ten marker compounds based comparative study of green tea and guava leaf by HPTLC densitometry methods: Antioxidant activity profiling. J. Sep. Sci. (2011), 34, 749–760.

  • Yousuf, S.K.; Majeed, R.; Ahmad, M.; Sangwan, P.L.; Purnima, B.; Saxena, A.K.; Suri, K.A.; Mukherje, D.; Taneja, S.C. Ring A structural modified derivatives of withaferin A and the evaluation of their cytotoxic potential. Steroids (2011), 76, 1213–1222.

  • Kour, K.; Sangwan, P.L.; Khan,I.; Koul, S.; Sharma, S.N.; Kitchlu, S. ; Bani S. Alcoholic extract of Cicer microphyllum augments Th1 immune response in normal and chronically stressed Swiss albino mice. J Pharmacy and Pharmacology. (2011), 63, 267-277.

  • Reddy, M.V.; Thota ,N.; Sangwan, P.L.; Malhotra, P.; Ali, F.; Khan, I.A.; Chimni ,S.S.; Koul ,S. Novel bisstyryl derivatives of bakuchiol: targeting oral cavity pathogens. Eur J. Med. Chem. 2010, 45(7):3125-34.

  • Pandey, A.; Bani, S.; Sangwan, P.L.; Koul, S. Selective Th1 upregulation by ethyl acetate fraction of Labisia pumila. J Ethanopharmacology(2010), 132, 309-15.

  • Singh, G.D.; Ganjoo, M.; Youssouf, M.S.; Koul, A.; Sharma, R.; Singh, S.; Sangwan, P.L.; Koul, S.; Ahamad, D.B.; Johri’ R.K. Sub-acute toxicity evaluation of an aqueous extract of Labisia pumila, a Malaysian herb. Food Chem. Toxicol. (2009), 10, 661-65.

  • Sangwan, P.L.; Koul, J.L.; Koul, S.;  Reddy, M.V.; Khan, I.A.; Kumar, A.; Kalia, N.; Qazi. G.N. Piperine analogs as potent Staphylococcus aureus NorA efflux pump inhibitors. Bioorg. Med. Chem. (2008), 16, 9847-57.

  • Kumar, A.; Khan, I.A.; Koul, S.; Koul, J.L.; Taneja, S.C.; Ali, I.; Ali, F.; Sharma, S.; Mirza, Z.M.; Kumar, M.; Sangwan, P.L.Gupta, P.; Thota, N.; Qazi, G.N. Novel structural analogues of piperine as inhibitors of the NorA efflux pump of Staphylococcus aureus. J. Antimicrob. Chemother. (2008), 61, 1270.

Patents

  • Koul,S.;Reddy,M.V. ; Sangwan,P.L. ; Singh, B. ;Kumar,C.P. ; Khan,I.A. ; Kalia,N.P. ; Nargotra, A. ; Vishwakarma,R.A. (2011). Novel diamides as potentiation of the bioefficacy of drugs.(NF0042/11).

  • Bani,S ; Pandey,A; Chouhan,PS; Chandan,BK; Sharma, N; Singh,K; Koul,S; Sangwan,P.L. ; Gupta,DK; Lal,S. (2009) .Adaptogenic activity of Labisia pumila extracts.(US patent filed 2009 WO 2010/147449A1).

  • Koul,S; Reddy,MV; Thota,N; Koul,JL; Sangwan, P.L.;Taneja,SC. ; Khan,IA.; Kumar,A.; Kalia, N .; Abdullah,TS.; Johri,RK.; Tikoo,AK.; Tikoo, MK.; Saxena,AK.; Agrawal,SK.; Mondhe,DM.; Purnima, B .; Sharma,S.; Singh, S.; Singh,GD.; Bhusari,S.; Qazi,GN.(2008) Novel aromatic amides as Potentiator of bioefficacy of drugs..(U.S. Patent NF0113 2008).

  • Qazi, G.N. .; Bani,S..; Chandan, B.K. .; Koul,A..; Kour,K .; Pandey,A.; Chouhan,P.S.; Koul, S. ; Gupta,B.D.; Sangwan,P.L.; Raina, Rajan .(2007)Immunopotentiating composition from Labisia pumila extract. PCT/MY2007/000078 WO 2009/064155A1.

  • Qazi, GN; Bani,S .; Chandan,BK .; Koul,A.; Kour, K.; Pandey,A.; Chouhan,PS.; Koul,S.; Gupta,BD.; Sangwan,P.L..; Raina, RK.;Rajan .Novel composition obtained from Labisia pumila extract for heptoprotective activity.((2007) PCT/MY2007/000079 WO 2009/064156A1).

  • Koul,S.; Thota,N.; Reddy,MV.; Sangwan,P.L..; Taneja,SC.; Khan,IA .; Kumar,A.; Raja, AF.; Saxena,AK.; Agrawal,SK.; Johri, RK .; Abdullah, TS.;Singh,GD .; Rao,BLN .; Dhar,AK.; Purnima,B.; Qazi,GN. (2007).Novel efflux pumps inhibitors.( U.S. Patent (NF 193 (2007), 0525DEL2008) WO 2009/110002A1).

CSIR Fellow

1
Mr. Nisar A. Dangroo 
2
Mr. Alamgir A. Dar
3
Mr. Santosh Rath
4
Ms. Nidhi
5
Mr. Arun Kumar Raina
Facilities
1
LCMS
2
HRMS
3
NMR (400MHz, 500MHz)
4
HPLC
5
Flash Chromatography
6
IR