Dr. Ravi Shankar

Bio-Organic Chemistry Division
CSIR - Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: rshankar@iiim.ac.in; rsnorg@gmail.com

Positions Held  
Position Held Date Organization
Scientist 2013 - Present CSIR-IIIM
Post-doctoral fellow 2011 - 2013 University of Georgia, Athens, USA
Post-doctoral fellow 2010 - 2011 University of Illinois, Chicago, USA
Post-doctoral fellow 2009 - 2010 University of Maryland, Baltimore, USA

Honours & Awards

  • Awarded Junior Research Fellowship of the Council of Scientific and Industrial Research, Government of India (2004).

  • Awarded Certificate of Excellence. Antiviral Drug Discovery, University of Georgia (2013).

Membership

  • Member of American Association for the Advancement of Science (AAAS), (USA).

  • Reviewer of many National and International Journals and Grants, Research Grant (DST, SERB, India), International ASTAR Grant, Singapore , Medicinal Research Reviews, Mini Reviews in Medicinal Chemistry, Bioorganic and Medicinal Chemistry Letters, Chemical Biology & Drug Design ,Tetrahedron.

Research Interests

Design and synthesis of small organic molecules of biological interes

Bioorganic & Medicinal Chemistry, 2009, 3847-3856; 

Bioorganic & Medicinal Chemistry, 2009, 3847-3856; 

Eur. J. Medicinal Chemistry, 2008, 43, 2149- 2158.

Site specific drug delivery
Our interest to develop polymeric systems to carry small molecular weight therapeutics at specific sites by passive targeting as well as active targeting. The prerequisite for such polymeric therapeutics is to release the drug at targeted sites with maximizes the drug release by pH or enzyme based degradation.

Mol. Pharmaceutics201310 (10), pp 3776–3788

Development of new methodologies
A key aspect of our research program is to develop new methods towards construction of natural and pharmaceutically relevant compounds

J. Org. Chem., 201479 (9), pp 3917–3923

Tetrahedron Letter 47 (22), 3077-3079

RSC Adv., 2015,5, 10567-10574
Asian J. Org. Chem. 20154, 573.

Publications
  • Dheer, D.; Singh, V; Shankar, R. Medicinal Attributes of 1, 2, 3-Triazoles: Current Developments. Bioorg Chem (2017) 71, 30-54.

  • Singh, D.; Kumar, V.; Devi, N.; Malakar, C. C.; Shankar, R.; Singh, V. Metal–free Decarboxylative Amination: An Alternative Approach Towards Regioselective Synthesis of β-Carboline N-fused Imidazoles. Adv. Synth & Catal (2017) 359 (7), 1213-1226.

  • Borgohain, H.; Devi, R.;  Dheer, D.; Borah, B.J.;  Shankar, R.; Das, S.K. Synthesis of Tetrahydroquinoline-Embedded Bridged Benzothiaoxazepine-1,1-dioxides. Eur J Org Chem (2017) 45, 6671-6679.

  • Shankar, R.; Rawal R.K.; Singh, U.S.; Chaudhary, P.; Konwar, R.; Hajela, K. Design, synthesis and biological evaluation of hydrazone derivatives as anti-proliferative agents. Med Chem Res (2017) 26 (7), 1459–1468.

  • Dheer, D.; Rawal R.K.; Singh, V.; Sangwan, P.L.; Das, P.; Shankar, R. β-CD/CuI catalyzed regioselective synthesis of iodo substituted 1,2,3-triazoles, imidazo[1,2-a]-pyridines and benzoimidazo[2,1-b]thiazoles in water and their functionalization. Tetrahedron (2017) 73 (30), 4295–4306.

  • Manjal, S.K.; Kaur ,R.; Bhatia, R.; Kumar, K.; Singh, V.; Shankar,  R.; Kaur, R.; Rawal R.K. Synthetic and Medicinal Perspective of Thiazolidinones: A Review.  Bioorg Chem (2017) 75, 406-423.

  • Singh, B.; Sharma, S.; Taneja, S. C.; Shankar, R.; Sangwan, P. L. -(Methoxy-(substitutedphenyl)-methyl)-?-butyrolactones: A short synthesis from cinnamyl acetate. Synthetic Commun.,(2016),46(4),361-366.

  • Arora, D.; Sharma, N.; Sharma V.; Abrol, V.; Shankar, R.; Jaglan, S. An update on polysaccharide-based nanomaterials for antimicrobial applications. Applied Microbiology and Biotechnology, (2016), 100(6), 2603-2615.

  • Dheer, D.; Arora, D.; Jaglan, S.; Rawal, R. K.; Shankar, R. Polysaccharides based nanomaterials for targeted anti-cancer drug delivery. Journal of Drug Targeting (2017), 25(1), 1-16.

  • Dheer, D.; Reddy, K.R.; Rath S.K.; Sangwan, P. L.; Das, P.; Shankar, R. Cu(I)-catalyzed double CH amination: synthesis of 2-iodo-imidazo[1,2-a]pyridines, RSC Adv. (2016), 6, 38033-38036.

  • Dangroo, N.A.; Dar, A.A.; Shankar, R.; Khuroo, M.A.; Sangwan, P.L. An efficient synthesis of phosphoramidates from halides in aqueous ethanol. Tetrahedron Letters (2016), 57(25), 27172722.

  • Kumar, B.; Singh, V.; Shankar, R.; Kumar, K.; Rawal, R.K. Synthetic and medicinal prospective of structurally modified curcumins. Curr Topics in Med Chem (2017), 17(2), 148-161.

  • Reddy, K.R.; Reddy, A. S.; Shankar, R.;  Kant, R.;  Das, P. Copper-Catalyzed Oxidative C−H Amination: Synthesis of Imidazo[1,2-a]-N-Heterocycles from N-Heteroaryl Enaminones. Asian J. Org. Chem. (2015), 573-583.

  • Reddy, K.R.; Reddy, A. S.; Dhaked,, D. K.; Rasheed, S.K.; Pathania, A. S.; Shankar, R.; Malik, F.; Das P. Palladium-catalyzed arylation of 2 H-chromene: a new entry to pyrano [2, 3-c] carbazoles. Org. Biomol. Chem.,(2015), 13, 9285-9293

  • Rasheed, Sk.; Rao, D. N.; Reddy, A. S.; Shankar, R.; Das, P. Sulphuric acid immobilized on silica gel (H2SO4-SiO2) as an eco- friendly catalyst for transamidation, RSC Advances, (2015), 10567-10574.

  • Singh, U. S.; Mishra, R. C.; Shankar,  R.; Chu,  C. K. Stereoselective synthesis of 2'-fluoro-6'-methylene carbocyclic adenosine via Vince lactam.  J Org Chem. (2014), 3917-3923.

  • Shankar, R.; Samykutty, A.; Riggin, C.; Kannan, S.; Wenzel, U.;  Kolhatkar, R. Cathepsin B Degradable Star Shaped Peptidic Macromolecules for Delivery of 2-methoxyestradiol, Mol. Pharmaceutics, (2013), 3776-3788.

  • Ansari, MI.; Shankar, R.; Hussain, M. K.; Kant, R.; Maulik, P. R.; Kumar, K. R.; Hajela, K. Eco-Friendly HClO4–SiO2 Catalyzed Synthesis of Mono- and Bis-diaryl-2H-1,4 Benzothiazines. Journal of Heterocyclic Chemistry, (2011), 1336-1341.

  • Shankar, R.; Singh, U. S.; Shukla, H.; Thakur, V.; Hajela, K. A facile one pot synthesis of 4-aroyl-2-pyrones: via nuclliophillic addition of active methylene groups to 1, 2-diaroylacetylenes, Synthetic Communications (2011), 2738-2746.

  • Shankar, R.; Chakravarti, B.; Singh, U. S.; Kumar, S.; Dwivedi, S. K. D.; Bid, H. K.; Konwar, R.; Kharkwal, G.;  Chandra, V.; Dwivedi, A.; Hajela, K. Synthesis and Biological Evaluation of 3,4,6-Triaryl-2-Pyranones as a Potential New Class of Anti-breast Cancer Agents. Bioorganic & Medicinal Chemistry (2009), 3847-3856.

  • Singh, U. S.; Shankar, R.; Kumar, A.; Trivedi, R.; Chattopadhyay, N.; Shakya, N.; Palne, S.; Gupta, S.; Hajela, K. Synthesis and Biological Evalution of Indolyl Bispohosphonates as Anti-bone resorptiveand Anti-leishmanial agents. Bioorganic & Medicinal Chemistry (2008), 8482-8491.

  • Singh, U. S.; Shankar, R.; Singh, M. M.; Keshri, G.; Yadav, G. P.; Moulik, P. R.; Hajela, K. Synthesis and Structure Guided Evaluation of Estrogen Agonist and Antagonist Activities of Some New Teterazolyl Indole Derivatives. European Journal of Medicinal Chemistry (2008), 2149-2158.

  • Shankar, R.; Jha, A. K.; Singh, U. S.; Hajela, K. An efficient and improved synthesis of 1,5-diketones : versatile conjugate addition of nucleophiles to α , β-unsaturated enones and alkynones. Tetrahedron Lett., (2006), 3077-3079.

  • Shankar, R.; Jha, A.K.; Singh, U. S.; Keshri, G.; Dwivedi, A.; Balapure, A. K.; Singh, M. M.; Hajela, K. Synthesis of Some Novel Conformationally Constrained Tricyclic Compounds as Potential Estrogen Receptor Agonists/Antagnists. Med. Chem. Res. (2007), 237-238.

Current Students

CSIR Fellow
1
Divya Dheer, M.Pharm