Dr. Rajkishor Rai

Medicinal Chemistry Division
CSIR - Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: raj@iiim.ac.in

Positions Held  
Position Held Date Organization

Senior Scientist

2010 - Present CSIR-IIIM
 

Research Interest

  • Design, Synthesis and Conformational Studies of Peptides

  • Peptide Foldamers Containing Non-Protein Amino Acids

  • Biologically Active Natural Peptides

  • Peptide-Based Enzyme Inhibitors & Conjugates
Publications
  • Aravinda,S. ; Shamala,N.; Rai,R.; Gopi, H.N. ; Balaram,P. A Crystalline b- Hairpin Peptide Nucleated by a Type I’ Aib-DAla b-Turn: Evidence for Cross–Strand Aromatic Interactions. Angew. Chem. Int. Ed., (2002), 41, 3863-65.

  • Rai,R.; Raghothama,S. ; Balaram,P. Design of a Peptide Hairpin Containing a Central Three Residue Loop. J. Am. Chem. Soc. (2006),128, 2675-2681.

  • Rai, R.;Aravinda,S. ; Kanagarajadurai,K.;Raghothama,S. ; Shamala, N.;Balaram,P. Diproline templates as folding nuclei in designed peptides. Conformational analysis of synthetic peptide helices containing amino terminal Pro-Pro segment. J. Am. Chem. Soc.( 2006), 128, 7916-7928.

  • Rai,R.; Vasudev,P. G.; Ananda,K.; Raghothama,S. ; Shamala,N. ; Karle, I. L.;Balaram,P. Hybrid Peptides: Expanding the b-Turn in Peptide Hairpins by Insertion ofb, g and d Residues, Chemistry: A European Journal (2007), 13(20), 5917-5926.

  • Raghavender,U. S.; Aravinda,S.; Shamala,N.; Kantharaju; Rai,Rajkishor; Balaram,P.Characterization of Water Wires inside Hydrophobic Tubular PeptideStructures. J. Am. Chem. Soc. (2009) 131(42), 15130-15132.

  • Raghavender,U. S. ; Aravinda ,S. ; Rai,R.; N,Shamala ; alaram,P,B.; Peptide hairpin nucleation with the obligatory Type I' beta-turn Aib-(D)Pro segment. Org. Biomol. Chem. (2010), 8, 3133-3135.

  • Chandrappa,S.; Aravinda,S. ; Ragothama,S.; Rai,R.; Harini,V.; Shamala,N.; Balaram.,P. Helix and Hairpin Nucleation in Short Peptides Using Centrally Positioned Conformationally Constrained Dipeptide Segments. Org. Biomol. Chem. (2012), 10, 2815-2823.

  • Chhabra,A.; Haque,A. S.;  Pal,R. K.;Goyal, A. ; Rai,Rajkishor; Joshi,S. ; Panjikar,S. ; Pasha,S. ; Sankaranarayanan,R. ; Gokhale,R. S. Nonprocessive [2+2]e- Offloading Reductase Domains fromMycobacterial Non-ribosomal Peptide Synthetases. Proc. Natl. Acad. Sci. USA 2012, 109, 5681-5686.

  • Aravinda,S.; Raghavender,U. S.; Rai,R.; Harini,V. V. ; Shamala,N.; Balaram, P. Crystallographic Analysis of Designed β-Hairpin Peptides:Molecular Conformation and Packing in Crystals. Org. Biomol. Chem. (2013), 11, 4220-4231.

  • Wani,N. A.; Gupta,V. K.; Kant, R.;Aravinda,S. ; Rai,R. Conformation of a terminally protected bg hybrid dipeptide Boc-Ant-Gpn-OMe stabilized by C6/C7hydrogen bonds. Acta Cryst. (2014), C70, 46.

  • Wani,N. A.; Gupta,V. K. ; Kant,R.; Aravinda,S. ; Rai,R. An unusual conformation of gabapentin (Gpn) in Pyr-Gpn-NH-NH-Pyr stabilized by weak interactions. Acta Cryst. (2014), C70, 776.

Book Chapter
  • Rai,R; Balaram,P. Control of Polypeptide Chain Folding and Assembly in Book “Foldamers: Structure, Properties and Applications” Edited by Ivan Huc and Stefen Hecht, (2007), 147-172. Wiley- VCH Verlag GmbH & Co. KGaA, Weinheim Publishers