Dr. P. R. Sharma            

Cancer Pharmacology Division
CSIR - Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: prsharma@iiim.ac.in, prsharma2k1@rediffmail.com

Positions Held  
Position Held Date Organization
Principal Technical Officer   CSIR-IIIM
Honours & Awards  
  • Got 2nd prize in oral presentation of the following paper at Delhi University:Sharma, P. R., Shanmugavel, M., Saxena, A. K. and Qazi, G. N.  Induction of Apoptosis by  a Synergistic Lignan Composition from Cedrus deodara in Human Cancer Cells.  Nat. Con. on Electron Microscopy & XXIX Ann. Meet. EMSI,( 2007), Univ. of Delhi, New Delhi, Nov. 26-28,.

  • The article given below published  in Chemico-Biological Interactions is one of the journal's top ten most downloaded articles of 2009.  Sharma, P. R.,  Mondhe, D. M.,  Shanmugavel, M.,  Pal, H. C.,  Shahi, A. K., Saxena, A. K., and Qazi, G. N. Anticancer activity of an essential oil from Cymbopogon flexuosus. Chem. Biol. Interact,(2009), (179): 160-168.

Membership  
  • Life member, Electron Microscopic Society of India (EMSI)

Research Area

  • Mechanistic studies of natural and semi-synthetic anticancer   leads    using    electron  microscopic  and    confocal     microscopic techniques.

  • Electron  and confocal microscopic studies of both biological and material samples. 

  • Operation of scanning cum transmission electron microscope  (JEOL-JEM100CXII) and operation of  laser scanning confocal microscope (Olympus, Fluoview, FV1000).

  • Insect pest and vector control.

Area of Interest:

  • Ultrastructural  studies of human cancer cells and murine tumour  cells and tissues to ascertain  the effect on ultrastructure of cells  and to study the mechanism of  cell death such as apoptosis, autophagy etc.  for anticancer drug  discovery. Ultrastructural studies of other biological samples for drug discovery.

  • Live cell imaging, fluorescence, immunofluorescence and confocal microscopic studies of human cancer cells for anticancer drug discovery. Laser scanning  confocal microscopic studies of other biological samples for drug discovery.

  • Mosquito control using  biolarvicides.

Scientific Contribution         

  • More than twenty five years experience in electron microscopic studies of biological samples and on evaluation of insecticidal activities of biopesticides on all major groups of insect pests/vectors.

  • Sample processing & ultrastructural studies of biological/material samples such as pollen grains, plant viruses, nanoparticles, liposomes, insect hemocytes, human cancer cells and murine tumour tissues have been done.

  • The protocols have been optimized for of live cell imaging, fluorescence, immunofluorescence and confocal microscopic studies of human cancer cells for  anticancer drug discovery.

  • In the mechanistic studies of anticancer lead molecules/fractions using human cancer cell lines/murine tumor tissues the protocols for mechanism of cell death i. e., apoptosis, necrosis and autophagy using scanning and transmission electron microscope have been optimized. Morphological, surface and internal ultra structural studies of human cancer cells and murine tumour tissues have been done in case of anticancer leads.

  • Optimized  the protocols for screening of anticancer leads using  transgenic Drosophila  and screened  a large number of the anticancer leads on this Model.

  • In the area of insect pest/vector control, the insecticidal activity of botanicals was determined on economically important insect pests. The colonies of  filariasis vector, Culex quinquefasciatus,  dengue fever mosquito, Aedes aegypti andAsian tiger mosquito, A. albopictus have been established and protocols for evaluation of bioefficacy of microbial mosquito larvicides have been optimized. A large number of samples have been screened on mosquito larvae with the objective of development of cheap medium for production of mosquito larvicides. Simulated  and open field trials were done for mosquito larval control using microbial larvicides.

  • All these above studies have lead to the publications and patents.

  • Supervising the research work of Ph. D students.  Supervised more than thirty students from different universities for their project work forming a part of their degree programmes like M.Sc. /B.Tech  in Biosciences/  Biochemistry /Biotechnology.

Publications
  • Sharma, P. R.; Tikku, K. ; Saxena, B. P.; An electron microscopic study of normal haemocytes of Poecilocerus pictus (Fab.) and their response to injected yeast cells. Insect Sci. Applic. (1986),  7(1), 85-91.

  • Saxena, B. P.;Sharma, P. R.; Tikku, K.;. Scanning electron microscopical studies of the haemocytes of  Spodoptera litura fabr. Cytologia,( 1987) ,53, 385-391.

  • Saxena, B. P.; Sharma, P. R.; Thappa, R. K.; Tikku, K.. Temperature induced sterilization for control of three stored grain beetles. J. stored Prod. Res., (1991),28(1), 67-70.

  • Saxena, B. P. ; Sharma, P. R. ; Ultrastructural study of free circulating reticular cells of Dysdercus koenigii F. and changes induced by yeast cells. Proc. Indian. Natn. Sci. Acad.( 1995.),B61 No.1, 39-44.

  • Sharma, P. R.; Thappa, R. K.; Tikku, K.; Chand, D.; Saxena, B. P.;. Control of stored- product moths and beetles by suboptimum temperatures. Tropical Sci., (1997),37, 28-34.

  • Sharma, P. R.; Tikku, K. ; Saxena, B. P. ; A light and electron microscopic study of the haemocytes of adult red cotton bug, Dysdercus koenigii. Biologia, Bratislava,( 1998),53/6, 759-764.

  • Sharma, P. R.; Sharma, O. P. ; Saxena, B. P. ;. Ultrastructure of the haemocytes of tobacco armyworm, Spodoptera litura Fab. (Lepidoptera; Noctuidae). Biologia, Bratislava, (2001),56(3), 277-285.

  • Sharma, P. R.; Sharma, O. P.; Saxena, B. P.. Effect of Neem gold on haemocytes of the tobacco armyworm, Spodoptera litura Fab. (Lepidoptera; Noctuidae). Curr. Sc.( 2003) ,84(5), 690-695.

  • Lattoo, S. K.; Dhar, R. S.; Dhar, A. K.; Sharma, P. R. ; Agarwal, S. G. Dynamics of essential oil biosynthesis in relation to influorescence and glandular ontogeny in Salvia sclarea. Flavour  Fragr. J., (2006),21: 817-821.

  • Lattoo, S. K.;Khan S.; Dhar, A. K.; Choudhary D. K.; Gupta K. K.; Sharma, P. R. Genetics and mechanism of induced male sterlity in Andrographis paniculata (Burm. F) Nees and its significance. Curr. Sc., (2006),91 (4): 515-519.

  • Sharma, P. R.; Shanmugavel, M.; Saxena, A. K.; Qazi, G. N. Induction of apoptosis by a synergistic lignan composition from Cedrus deodara in human cancer cells. Phytother. Res. , (2008) ,(22):1587-1594.

  • Sharma, P. R.; Sharma, O. P.; Saxena, B. P. Effect of sweet flag rhizome oil (Acorus calamus) on hemogram and ultrastructure of hemocytes of the tobacco armyworm, Spodoptera litura (Lepidoptera: Noctuidae). Micron, (2008), (39): 544-551.

  • Sharma, P. R.;  Mondhe, D. M.;  Shanmugavel, M.;  Pal, H. C.; Shahi, A. K.; Saxena, A. K.; and Qazi, G. N. Anticancer activity of an essential oil from Cymbopogon flexuosus. Chem. Biol. Interact. (2009) , (179): 160-168.

  • Mukherjee, A.; Hazra, S.; Dutta, S.; Shanmugavel, M.; Mondhe, D. M.; Sharma, P. R.; Singh, S. K.; Saxena, A. K.;  Qazi, G. N. ;Sanyal, U.. Antitumor efficacy and apoptotic activity of substituted chloroalkyl 1H-benz[de]isoquinoline-1,3-diones: a new class of potential antineoplastic agents. Invest New Drugs, (2010),DOI 10.1007/s10637-009-9372-z.

  • Sharma, M.; Agrawal, S. K.; Sharma, P. R.; Chadha, B. S.; Khosla M. K. ; Saxena, A. K. Cytotoxic and apoptotic activity of essential oil from Ocimum viridae towards COLO 205 cells. Food Chem. Toxicol. , (2010),(48): 336-344.

  • Chashoo,  G.; Singh, S. K.; Sharma, P. R.;  Mondhe, D. M.; Dar, A. H.;  Saxena, A.; Andotra, S. S.; Shah, B. A. ;Qazi, N. A.; Taneja, S.C. ; Saxena, A. K. A propionyloxy derivative of 11-keto-β-boswellic acid induces apoptosis in HL-60 cells mediated through topoisomerase  I & II inhibitionChem. Biol. Interact. (2011) , (179): 160-168.

  • Mukherjee, A.; Dutta S.;  Shanmugavel M.; Mondhe D. M.; Sharma P. R.; Singh, S. K.; Saxena, A. K.;  Sanyal U. 6-Nitro-2-(3-hydroxypropyl)-1H-benz[de] isoquinoline-1,3-dione, a potent antitumor agent, induces cell cycle arrest and apoptosis. J Exptl.  & Clin. Can. Res. , (2010) ,29:175.

  • Kumar, M.; Kumar, N.; Bhalla, V.; Singh, H.; Sharma, P. R.; Kaur, T. Naphthalimide Appended Rhodamine Derivative: Through Bond EnergyTransfer for Sensing of Hg2+Ions. Org. Lett., (2011) ,13(6): 1422-1425.

  • Kaur, R.; Khan, S.; Chib, R.; Kaur, T.; Sharma, P. R.; Singh, J.; Shah, B. A.; Taneja S.C. A comparative study of proapoptotic potential of cyano analogues of boswellic acid and 11-keto-boswellic acid. Eur J. Med. Chem., (2011) ,46: 1356-1366.

  • Patial, J.; Dar, B. A.; Sharma, P.; Kusnuru,  A. K.; Sharma, P. R.; Ray, S. K.; Mukharjee, D. ; Singh, B. Pore-engineered silica-alumina: texture, acidity and activity for conversion of longifoline to isolongifoline. Monatsh , (2011) ,DOI10.1007/s00706-011-0666-4 .
  • Tripathi, A. K.; Mukherjee, D.; Koul, S.; Taneja, S. C.; Agrawal, S. K.; Sharma, P. R. ;  Saxena, A. K. Synthesis and cytotoxicity of novel benzopyran derivatives. Ind. J. Chem. (2011) ,50B: 1619-1629.

  • Paliwal, S. R.; Paliwal, R.; Pal, H. C.; Saxena, A.K.; Sharma, P. R.; Gupta, P. N.; Agrawal, G. P. ;Vyas, S. P. Estrogen-Anchored pH-Sensitive Liposomes as Nanomodule  Designed for Site-Specific Delivery of Doxorubicin in Breast Cancer Therapy.  Mol. Pharmaceutics , (2012) ,9 (1):  176–186.

  • Kumar, M.; Kumar, R.; Bhalla, V.; Sharma, P. R.; Kaur, T. ;Qurishi, Y. Thiacalix[4]arene based fluorescent probe for sensing and imaging of Fe3+ions. Dalton Trans., (2012)  ,  41: 408-412.

  • Kumar, M.; Kumar, N.; Bhalla, V.; Sharma, P. R.;  Kaur, T. Highly Selective Fluorescence Turn-on Chemodosimeter Based on Rhodamine for Nanomolar Detection of Copper Ions .Org. Lett., (2012) , 14(1): 406-409.

  • Ali, F.; Sangwan, P. L.; Koul, S.; Pandey, A.; Bani, S.; Abdullah, S. T.; Sharma, P. R.; Kitchlu, S. Khan, I. A. 4-epi-Pimaric acid: a phytomolecule as a potent antibacterial and anti-biofilm agent for oral cavity pathogens. Eur J Clin Microbiol Infect Dis., (2012) , 31:149–159.

  • Kaur, P.; Kaur, S.;Singh,K.; Sharma, P. R.;Kaur, T. Indole-Based Chemosensor for Hg2+ and Cu2+ Ions: Applications in Molecular Switches and Live Cell Imaging.Dalton Trans., (2011) ,40: 10818-10821.

  • Chashoo, G.; Singh S. K.; Mondhe, D. M.; Sharma, P. R.; Andotra, S. S.; Shah, B. A.; Taneja, S. C. ; Saxena, A. K. Potentiation of the antitumor effect of 11-keto-β-boswellic acid by its 3-α-hexanoyloxy derivative.Eur. J. Pharm. , (2011) ,668 ,390–400.

  • Bhalla, V.; Roopa, Kumar, M.; Sharma, P. R.; Kaur, T. New Fluorogenic Sensors for Hg2+ Ions: Through-Bond Energy Transfer from Pentaquinone to Rhodamine. Inorg. Chem. , (2012) , 51: 2150−2156.

  • Bhalla, V.; Vij, V.; Kumar, M.; Sharma, P. R.; Kaur, T. Recognition of Adenosine Monophosphate and H2PO4 using Zinc Ensemble of New Hexaphenylbenzene Derivative: Potential Bioprobe and Multichannel Keypad System.Org. Lett. , (2012) ,12:10-12-1015.

  • Agrawal, S. K.; Agrawal, M.; Sharma, P. R.; Gupta, B. D.; Arora, S. ; Saxena, A. K. Induction of Apoptosis in Human Promyelocytic Leukemia HL60 cells by an Extract From Erythrina suberosaStem Bark. Nutrition & Cancer , (2011) ,63(5): 802-813.

  • Kamal  A.; Srikanth, Y. V. V.; Khan, M. N. A.; Ashraf, M.; Reddy, M. K.; Sultana, F.; Kaur, T.;Chashoo, G.; Suri, N.; Sehar, I.; Wani, Z. A.; Saxena, A.; Sharma, P. R.; Bhushan, S.; Mondhe, D. M.; Saxena, A. K. 2-Anilinonicotinyl linked 2-aminobenzothiazoles and [1,2,4]triazolo[1,5-b] [1,2,4]benzothiadiazine conjugates as potential mitochondrial apoptotic inducers. Bioorg. Med. Chem., (2011) , 19: 7136-7150.

  • Kumar, M.; Kumar, N.; Bhalla, V.; Sharma, P. R.; Qurishi, Y. A charge transfer assisted fluorescent probe for selective detection of hydrogen peroxide among different reactive oxygen species. Chem. Commun., (2012) , 48, 4719-4721.

  • Qurishi, Y.; Hamid, A.; Sharma, P. R.; Wani, Z. A.;  Mondhe, D. M.; Singh, S. K.; Zargar, M. A.; Andotra, S. S.; Shah, B. A.; Taneja, S. C.; Saxena, A. K. PARP cleavage and perturbance in mitochondrial membrane potential by  3-α-propionyloxy- β-boswellic acid results in cancer cell death and tumor regression in murine models.  Future Oncol., (2012) , 8(7): 867-881.

  • Amna, T.;  Amina, M.; Sharma, P. R.; Puri, S. C.; Al-Youssef, H. M.; Al-Taweel, A. M.; Qazi, G. N. Effect of precursors feeding and media manipulation on production of novel anticancer prodrug camptothecin from endophytic fungus. Braz. J. Micr, (2012), 1476-1489, ISSN 1517-8382. 

  • 35.Dar, B.  A.; Sahu, A. K.; Patidar,  P.; Sharma,  P. R.; Mupparapua, N.; Vyas, D.;  Maity, S.; Sharma,  M.; Singh, B. Heteropolyacid-clay nano-composite as a novel heterogeneous catalyst for the synthesis of 2,3-dihydroquinazolinones . J. Indus. & Eng. Chem., (2012),19: 407-412.

  • Dar, B. A.; Chakraborty, A.; Sharma, P. R.; Shrivastava, V.; Bhowmik, A.; Vyas, D.; Bhatti, P.; Sharma, M.;  Singh, B. Grinding-induced rapid, convenient and solvent free approach for the one pot synthesis of a-aminophosphonates using aluminium pillared interlayered clay catalyst. J. Indus. & Eng. Chem. (2012), 19: 732-738.

  • Singh, P. P.; Thatikonda, T.; Kumar, K. A. A.; Sawant, S. D.; Singh, B.; Sharma, A. K.; Sharma., P. R.; Singh, D.; Vishwakarma, R. A. Cu−Mn Spinel Oxide Catalyzed Regioselective Halogenation of Phenols and N-Heteroarenes. J. Org. Chem., (2012), 77: 5823-5828.

  • Bharate, S. B.; Bharate, J. B.; Khan, S. I.; Tekwani, B. L.; Jacob, M. R.; Mudududdla, R.; Yadav, R. R.; Singh, B.; Sharma, P. R.; Maity, S.; Singh, B.; Khan, I. A.; Vishwakarma, R. A. Discovery of 3, 30-diindolylmethanes as potent antileishmanial agents. Eu. J. Med. Chem., (2013), 63: 435-443.

  • Bhushan, S.;  Kakkar, V.; Pal, H. C.; Guru, S. K.; Kumar, A.;  Mondhe,  D. M.; Sharma, P. R.; Taneja, S. C.; Kaur, I. P.; Singh, J. ; Saxena, A. K. Enhanced Anticancer Potential of Encapsulated Solid Lipid Nanoparticles of TPD: A Novel Triterpenediol from Boswellia serrata. Dx.doi.org/10.1021/mp300385m. Mol. Pharmaceutics, (2013) ,10: 225-235.

  •  Qurishi, Y.; Hamid, A.; Sharma, P. R.; Wani, Z. A.; Mondhe, D. M.; Singh, S. K.; Zargar, M. A.; Andotra, S. S.; Shah, B. A.; Taneja, S. C. ; Saxena, A. K. NF-ĸB Down–regulation and PARP Cleavage by novel 3-α-butyryloxy-β-boswellic Acid Results in Cancer Cell Specific Apoptosis and in vivo Tumor Regression. Anti-Can Ag Med Chem. (2013) ,13(5):  777-790.

  • Kumar, M.; Qadri, M.; Sharma, P. R.; Kumar, A.; Andotra, S. S.; Kaur, T.; Kapoor, K.; Gupta, V. K.; Kant, R.; Hamid, A.; Johri, S.; Taneja, S. C.; Vishwakarma, R. A.; Hassan, S. R. U.;Shah, B. A. Tubulin Inhibitors from an Endophytic Fungus Isolated from Cedrus deodara.  J. Nat. Prod. (2013) ,76(2): 194-199 dx.doi.org/10.1021/np 3006666.

  • Kumar, S.; Mehndiratta, S.; Nepali, K.; Gupta, M. K.; Koul, S.; Sharma, P. R.; Saxena, A. K. ; Dhar, K. L. Novel indole-bearing combretastatin analogues as tubulin polymerization inhibitors . Org. Med. Chem. Lett., (2013) , 3:3: 000-000.

  •  Sawant, S. D.; Srinivas, M.; Kumar, K. A. A.; Reddy, G. L.; Singh, P. P.; Singh, B.; Sharma, A. K.; Sharma, P. R.; Vishwakarma, R. A. Ligand-free C–N bond formation in aqueous medium using a reusable Cu–Mn bimetallic catalyst. Tetrahedron Lett. (2013)  , 54: 5351-5354.

  • Jasua, N. D.; Sharma, P. R.; Sharma, S.; Joshi, S. C. Development of non-invasive transdermal patch of Emblica officinalis for antiatherosclerotic activity. Int. J. Drug Delivery, (2013),5(4):402-411.

  • Rafiq, S.; Majeed, R.; Qazi, A. K.; Ganai, B. A.; Wani, I.; Rakhshanda, S.; Qurishi, Y.; Sharma, P. R.; Hamid, A.; Masood, A.; Hamid, R. Isolation and antiproliferative activity of Lotus corniculatus lectin towards human tumour cell lines. Phytomedicine, (2013),21(1): 30-38.

  • Singh, G.; Kaur, A.; Sharma, V.; Suri, N.; Sharma, P. R.; Saxena, A. K.; Ishar, M. P. S. Synthesis and cytotoxicity evaluation of regioisomeric substituted N-phenyl-30-(chrom-4-one-3-yl)- isoxazolidines: induction of apoptosis through a mitochondrial-dependent pathway. Med. Chem. Commun., (2013), DOI: 10.1039/c3md00055a.

  • Dar, B. A.; Patidar, P.; Kumar, S.; Wagay, M. A.; Sahoo, A. K.; Sharma, P. R.; Pandey, S.; Sharma, M.; Singh, B.  Fe–Al/clay as an efficient heterogeneous catalyst for solvent-free synthesis of 3, 4-dihydropyrimidones. J. Chem. Sci. (2013),125(3): 545-553.

  • Zilla, M. K.; Nayak, D.; Vishwakarma, R. A.; Sharma, P. R.;  Goswami, A.; Ali, A. A convergent synthesis of alkyne-azide cycloaddition derivatives of 4-α, β-2-propyne podophyllotoxin depicting potent cytotoxic activity. Eu. J. Med. Chem. , (2014),77: 47-55.

  • Gupta, M.; Chashoo, G.; Sharma, P. R.; Saxena, A. K.; Gupta, P. N.; Agrawal, G. P.; Vyas, S. P. Dual Targeted Polymeric Nanoparticles Based on Tumor Endothelium and Tumor Cells for Enhanced Antitumor Drug Delivery. Mol. Pharmaceutics. (2014), 11(3):, 697-715. dx.doi.org/10.1021/mp400404p | 

  • Singh, B.; Guru, S. K.; Kour, S.; Jain, S. K.; Sharma, R.;  Sharma, P. R.; Singh, S. K.; Bushan, S.; Bharate, S. B.; Vishwakarma, R. A. Synthesis, antiproliferative and apoptosis-inducing activity of thiazolo[5,4-d]pyrimidines. Eu. J. Med. Chem., (2013), 70: 864-874.

  • Majeed, R.;  Sangwan, P. L.; Chinthakindi, P. K.; Khan, I.;  Dangroo, N. A.; Thota, N.; Hamid, A.; Sharma, P. R.; Saxena, A. K.; Koul, S. Synthesis of 3-O-propargylated betulinic acid and its 1,2,3-triazoles as potential apoptotic agents. Eu. J. Med. Chem., (2013), 63: 782-792.

  • Pathania, A. S.;  Joshi, A.; Kumar, S.; Guru, S. K.; Bhushan, S.; Sharma, P. R.;  Bhat, W. W.; Saxena, A. K.; Singh, J.; Shah, B. A.; Andotra, S. S.; Taneja, S. C.;  Malik, F. A.;  Kumar, A. Reversal of boswellic acid analog BA145 induced caspase dependent apoptosis by PI3K inhibitor LY294002 and MEK inhibitor PD98059. Apoptosis, (2013),18(12):1561-73. doi: 10.1007/s10495-013-0889-4.

  • Kumar, S.;  Kumar, A.;  Pathania,  A. S.;  Guru, S. K.; Jada, S.; Sharma, P. R.; Bhushan, S.; Saxena, A. K.; Kumar, H. M. S.; Malik, F. Tiron and trolox potentiate the autophagic cell death induced by magnolol analog Ery5 by activation of Bax in HL-60 cells. Apoptosis, (2013) ,18(5): 605-617.

  • Farrukh, M. R.;  Nissar, Ul. A.;  Afnan, Q.;  Rafiq, R. A.;  Sharma, L.;  Amin, S.;  Kaiser, P.; Sharma, P. R.;  Tasdug, S. A. Oxidative stress mediated Ca2+ release manifests endoplasmic reticulum stress leading to unfolded protein response in UV-B Irradiated  human skin cells. J. Dermatol. Sc. ,( 2014),75: 24-35.

  • Agrawal, U.;  Chashoo, G.;  Sharma, P. R.;  Kumar, A.;  Saxena, A. K.;  Vyas, S. P.
     RGD-modified anticancer drug containing hybrid nanoparticles for the treatment of 3 integrins overexpressing glioma cells. J. Nanosci. Lett. (2014).

  • Rai, A.;  Jain, A.; Jain, A.; Jain, A.; Pandey, V.; Chashoo, G.;  Soni, V.; Sharma, P. R. Targeted SLNs for management of HIV-1 associated dementia. Drug Dev Ind Pharm, (2014) ,Early Online: 1–7.

  • Qazi, A. K.; Hussain, A.;  Aga, M. A.;  Ali, S.;  Taneja, S. C.;  Sharma, P. R.;  Saxena, A. K. ; Mondhe, D. M. ; Hamid, A. Cell specific apoptosis by RLX is mediated by NFκB in human colon carcinoma HCT-116 cells. BMC Cell Biology, (2014), 15:36.
    58. Katoch, M.;  Khajuria, A.; Sharma, P. R.;  Saxena, A. K. Immunosuppressive potential of Botryosphaeria dothidea, an endophyte isolated from Kigelia Africana. Pharm Biol . (2015) , 53(1): 85-91.

  • Singh, B.;  Kumar, A. ; Joshi, P. ; Guru, S. K. ; Kumar, S. ; Wani, Z. A. ; Mahajan, G. ; Hussain, A. ; Qazi, A. K. ; Kumar, A. ; Bharate, S. S. ; Gupta, B. D. ; Sharma, P. R. ; Hamid, A.; Saxena, A. K.; Mondhe, D. M.; Bhushan, S.; Bharate, S. B. ; Vishwakarma, R. A. Colchicine derivatives with potent anticancer activity and reduced P-glycoprotein induction Liability.  Org.Biomol. Chem. ,(2015) ,DOI: 10.1039/c5ob00406c. 13:5674-5689.

Patents

  • Taneja, S.C.; Singh, Jaswant; Saxena, A.K.; Shahi, A.K.; Sethi, V.K.; Mondhe, D.M.; Singh, Surjeet; Koul, M.K.; Chandra,
    Suresh; Andotra, S.S.; Kumar, Ajay; Bhushan Shashi; Singh, S.K.; Shanmugavel, M.; Sharma, P.R. and and Qazi, G.N.Cytotoxicity and anti-cancer activity of essential oil      from Cymbopoganflexuosus (Nees Ex Steud.) Wats. (Indian patent (0125NF2006; dated 25/01/2006) (1322/DEL/2007 dtd.19.06.2007).

  • Qazi, G.N.; Saxena, A. K.; Muthiah, Shanmugavel; Mondhe, D.M.; Sharma, P.R.; Singh, S.K.; Sanyal, U.; Mukherjee, A.; Hazra S.; Dutta, S. Substituted 2-[2-(hydroxyethyl)]- and [3-(hydroxypropyl)]-1H-benz[de]isoquinoline-1,3-diones as anticancer agents. (Indian patent (0078/NF/2007; dated 27/04/2007).

  • Qazi, Ghulam Nabi.;     Saxena, Ajit Kumar.; Muthiah, Shanmugavel.; Mondhe, Dilip Manikrao.; Sharma, Praduman Raj.; Singh, Shashank Kumar.; Sanyal, Utpal.; Mukherjee, Asama.; Hazra, Suva.; Dutta, Sushanta..Substituted 1h-Benz[De]Isoquinoline-1,3-Diones. (EP Patent No. EP2118065).

  • Kamal, A. ; Srikanth, Y.V.V. ; Khan, M.N.A. ; Ashraf, M. ; Sehar, I.;  Chashoo, G. ; Sharma, P.R. ; Dar, A.H. ; Bhushan, S. ; Singh, S.K. ; Mondhe, D.M. ; Saxena, A. K..2-Anilino nicotinyl linked 2-amino benzothiazole conjugates as potential anticancer agents, apoptosis inducers and process for the preparation thereof. (Indian and PCT patents filed (August 2010).

  • Vishwakarma, RA.; Sawant, SD.; Singh, PP.; Dar, AH .; Sharma, PR.; Saxena, AK.; Nargotra, A.; Shrinivas.; Hussain, A.; Qazi, AK.; Mahajan, P.. Synthesis and biological evaluation of isoform selective analogs of Tetrazoyl-Quinazolinone scaffolds as anticancer agents: PIK-α/δ inhibitors. (International/ Indian Patent Application Filed).

  • Vishwakarma, Ram A.; Sawant, Sanghapal Damodhar.; Singh, Parvinder Pal.; Dar, Abid Hamid.; Sharma, Parduman Raj.; Saxena, Ajit Kumar.; Nargotra, Amit.; Kumar, Kolluru Anjaneya Aravind.; Mudududdla, Ramesh.; Qazi, Asif Khurshid .; Hussain, Aashiq.; Chanauria, Nayan. (En)Boronic Acid Bearing Liphagane Compounds As Inhibitors Of Pi3k-Αand/Orβ(Fr) Composés Liphagane Porteurs D'acide Boronique Servant D'inhibiteurs De Pi3k-Α Et/Ou β.  (WO Patent No. WO/2013/140417).

  • Vishwakarma R, Bharate SB, Kumar A, Singh B, Kumar A, Bhushan S, Hamid A, Joshi P, Guru SK, Kumar S, Hussain A, Khurshid AQ, Bharate SS, Sharma P, Saxena AK, Mondhe DM, Mahajan G, Wani Z. 10-substituted colchicinoids as potent anticancer agents.(Patent Reference No. : 0059NF2014.DEL No.:   2929DEL2014. Filing Date: 14.10.2014).