Dr. Qazi Naveed Ahmed

Medicinal Chemistry Division
CSIR - Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: naqazi@iiim.ac.in, naqazi@iiim.res.in, qazirrl@gmail.com

Positions Held  
Position Held Date Organization
Senior Scientist 2012 - Present CSIR-IIIM
Assistant Professor 2010 - 2012 Higher Education Department, Govt. of India
Scientist fellow June 2010- Nov. 2010 CSIR-IIIM
Assistant Professor 2012 onwards AcSIR
Honours & Awards  
  • Post-Doctorial fellowship from University of Paris Sud-11 (France) under CNRS program (Aug 2008-Aug 2009).

  • Topped in PSC interviews held for Assistant Professor in Higher education department ( held in sep 2009)

  • Qualified for Research Fellowship-2008 awarded by Council of Scientific and Industrial Research, New Delhi, India.

  • Recipient of RRL best paper award for two research publications in 2005.

  • Best paper award of the Institute (2014) to one of my students

Membership
  • The Indian Science Congress Association

Synthetic Methodologies:

Amine promoted 2-Oxo driven unconventional reactions:

    Amine equivalence pathway (Synthesis of α-Ketoamides)

    Amino catalytic pathway (Synthesis of 1,2-diones)

    Amine equivalence pathway in presence of β-naphthol

    2-Oxo driven non traditional reactions:


    α-Carbonylimine to α-Carbonylamide: An Efficient Oxidative Amidation Approach

    Unexplored Reactivity of 2-Oxoaldehydes towards Pictet-Spengler condition

    Cu-Benzotriazole Catalyzed Electrophilic Cyclization/ Oxidative Coupling of N-Arylimines: A Methodical Tandem Approach to 4-Alkoxyquinazolines:

Medicinal chemistry


Development of Tadalafil as selective Antimalarial Candidate

Publications
  • Battini,N.; Battula,S.; Kumar,R.R.; Ahmed,Q.N.; 2‑Oxo Driven Unconventional reactions: Microwave Assisted Approaches to Tetrahydrofuro[3,2‑d]oxazoles and Furanones. Organic letters,( 2015), 17 (12), 2992–2995.

  • Padala,A.K.; Mupparapu,N.; Singh,D.; Vishwakarma,R.A.; Ahmed,Q.N . α-Carbonylimine to α-Carbonylamide: An Efficient Oxidative Amidation Approach, Eur. J. Org. Chem.(2015), 3577–3586.

  • Mupparapu,N.; Vishwakarma,R. A. ; Ahmed,Q.N .Iodine-DMSO promoted CeH (SP3) functionalization approach to a-ketoamides, Tetrahedron.(2015), 71, 3417-3421.

  • Mupparapu,N.; Battini,N.; Battula,S.; Khan,S.; Vishwakarma,R. A; Ahmed,Q.N . Aminocatalytic Cross Coupling Approach through Iminium to Different Exigent C-C Bonds, Chemistry A European Journal, (2015), 21, 2954 – 2960.

  • Kumar,S.; Pathania,A. S.; Guru,S. K. ; Mupparapu,N ; Kumar,A.; Malik,F.; Bharate,S. B.; Ahmed,N. Q.; Vishwakarma, R. A.;  Bhushan,S. A novel quinazolinone derivative induces cytochrome c interdependent apoptosis and autophagy in human leukemia MOLT-4 cells, Toxicology reports,( 2015), 1, 1013–1025.

  • Battini,N.; Padala,A. K.; Mupparapu,N.; Vishwakarma,R.A.; Ahmed,Q. N. Unexplored reactivity of 2-oxoaldehydes towards Pictet–Spengler conditions: concise approach to β-carboline based marine natural products, RSC Adv., (2014), 4, 26258–26263.

  • Battula,S.;. Vishwakarma,R. A; Ahmed,Q.N. Cu–benzotriazole-catalyzed electrophilic cyclization of N-arylimines: a methodical tandem approach to O-protected-4hydroxyquinazolines, RSC Adv., (2014), 4, 38375–38378.
  • Mupparapu,N.; Khan, S.; Battula,S.; Kushwaha,M.; Gupta, A. P. ; Ahmed, Qazi Naveed; Vishwakarma, Ram A. Metal Free Oxidative Amidation of 2-Oxoaldehydes: A Facile Access to α-Ketoamides, Organic letters, (2014), 16, 1152−1155.

  • Kanchithalaivan,S. ; Sivakumar,S; Kumar,R. R.; Elumalai,P.; Ahmed,Q. N.; Padala, A.K. Four-Component Domino Strategy for the Combinatorial Synthesis of Novel 1,4-Dihydropyrano[2,3-c]pyrazol-6-amines, ACS Comb. Sci. (2013), 15, 631−638.

  • Chashoo, G. ; Singh,S. K; Qazi,N. A; Saxena,A.K. Holistic Molecular Approaches for Anticancer Therapy,( 2012), 1 (1), 05-29.

  • Varma,S.; Raghupathy,R ; Yadav,M.l; Gannedi, V.;Singh,P. P. ; Qazi,N.A.; Sawant, S. D.;Mayor,S. ; Vishwakarma,R.A.. Synthesis of fluorescent label D and L inositol encompassing glycosyl-phosphatidylinositol membrane-anchors Tetrahedron letters, (2011), 52, 4277–4279. 

  • Reddy,D.M.; Qazi, N. A.;. Kumar,S.;  H. M;Sawant,S. D. ; Singh, S. K.; Verma,M.; Saxena,A. K.; SethiV. K. ;Taneja, S. C. Spiro-isoxazoline derivatives of parthenin as novel NF-kB inhibitor: Design and synthesis Europoen journal of Med. Chem. (2011), 46, 3210-3217.

  • Chashoo,G. ; Singh,S. K.; Sharma,P.R.; Mondhe,D.M.; Dar,A. H.; Saxena,A.; Andotra, S. S. ; Shah,B.A.; Qazi, N. A.; Taneja,Subhash C.; Saxena, A.K.A Propionyloxy derivative of 11-keto-β-boswellic acid induces apoptosis in HL-60 cells mediated through topoisomerase I & II inhibition .Chemico-Biological interactions, (2011), 189,60–71.

  • Kumar,H. M. Sampath; Singh,P. P.; Qazi,N. A. ; Malik,F. ; Sidiq,T.; Gupt,A.; Khajuria,A.; Suri,K.A. ; Satti, N.K.;Qazi,G.N. Synthesis of   novel analogs of Picrosides (I & II) useful as potential plant based adjuvants.Vaccine. (2010), 28, 8327–8337.

  • Singh,P. P.; Qazi, N. A.; Shafi,S.; Reddy,M. D.; Reddy,B.P.; Banday,A. H.; Suri,K. A. ; Gupta,B. D. ; . Satti,N. K; Kumar,H. M. Sampath; Qazi,G.N. Regiselectivbe acylation of biologically active important iridoid glycosides by Candida Antarctica lipase.Journal of molecular catalysis-B: Enzymatic.( 2009), 56, 46-54.

  • Tabasum I., P. P. Singh, S. Shafi, Naveed A. Qazi, Intzar Ali,  Khan,I. A .;b Kumar,H. M. S .;   & G. N. Qazi. Biologically active Hydroximoyl chlorides as Antifungal agents. Indian journal of Chemistry,(2008),may, 740-747.

  • Qazi,N. A.; Singh,P. Pal; Kumar,H. M. S. Anionic domino C-O-heterocyclization approach for the synthesis of 5-vinyl isoxazolines Synlett. (2007), 1449-1451.

  • Sawant, S. D.;Singh,P. P; Qazi,N. A.; Kumar,H. M. Sampath. Selective addition of allyl indium bromide to nitrile oxides in aqueous media; convenient synthesis of 5-methylisoxazolines . Chemistry Lett. ( 2007), 36, 296-297.

  • Kumar,H. M. Sampath; Qazi,N. A.; Shafi,S.; Kumar,V. N.; Krishna,A. D.; Yadav, J. S. Barbier allylation–Prins reaction of PEG-bound aldehydes—soluble polymer-supported synthesis of 2,4,6-trisubstituted tetra-hydropyrans Tetrahedron Lett. (2005), 46, 7205-7207.

  • Qazi,N.A. ; Kumar,H. M. S.; Taneja,S. C. Domino addition of allylzinc bromide to nitrile oxides: synthesis of 5-butenylisoxazolines Tetrahedron Lett. ,( 2005), 46, 4391-4393.

Patents

  • Kumar, H.M S.; Taneja, S. C.; Khajuria,A. ; Bani,S.;  Qazi,G. N.;  Qazi,N. A.;  Sawant, S. D.; Singh,P. Pal ;   Shafi, S. ;  Gupta,  A. Synthesis and immunomodulatory activity of selected 5-butenyl-3-arylisoxazoline. (WO 2009/110007 A1)

  • Kumar,H. M. S.; Sawant, S. D.;Qazi,N. A. ; Singh, S. K.; Verma,M.; Saxena, A. K. ; Sethi, V. K.; Taneja ,S. C. Synthesis and anti-cancer activity of novel spiro-isoxazoline derivatives of parthenin . ( WO/2009/110007)

Current Ph.D. Students

CSIR/ UGC Fellow
1
Mr. Anil K. Padala
2
Mr. Satyam Battula
3
Mr. Nagaraju Mupparapu
4
Mr. Narsaiah Battini
5
Mr. Atul Rana
INSPIRE Fellow
6
Mr. Shahnawaz Khan