Dr. Muzamil Ahmad

Pharmacology Division
CSIR - Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: mahmad@iiim.ac.in

Positions Held  
Position Held Date Organization
Pr. Scientist 2010 - Present CSIR-IIIM

Research

  • Cyclooxygenase metabolites in stroke injury

  • Neuroinflammation in stroke

  • Pharmacological intervention in stroke and Parkinson models

  • Molecular biomarkers in neurodegeneration

  • Signaling cascades in neurodegeneration

  • Plant based drugs in neurodegeneration

Publications
  • Ahmad ,M.; Liu, H.; Li ,W .; Rose, ME.; Miller, TM.; Yu, M.; Chen, J.; Pascoe ,JL.; Poloyac, SM.; Hickey, RW.; Graham ,SH. Increased Generation of Cyclopentenone Prostaglandins after Brain Ischemia and Their Role in Aggregation of Ubiquitinated Proteins in Neurons. Neurotox Res. (2013) Jan 25.

  • Ahmad, M .;Graham ,SH. Inflammation after Stroke: Mechanisms and Therapeutic Approaches. [Editorial Review]  Transl Stroke Res. 2010 Jun 1;1(2):74-84.

  • Liu ,H.; Li ,W.; Ahmad ,M .; Miller, TM.; Rose, ME.; Poloyac, SM.; Uechi ,G.; Balasubramani, M.; Hickey ,R.W.; Graham ,SH. Modification of ubiquitin-C-terminal hydrolase-L1 by cyclopentenone prostaglandins exacerbates hypoxic injury. Neurobiol Dis. 2011 Feb; 41(2):318-28.

  • Ahmad ,M .; Ahmad ,AS.; Maruyama ,T.; Narumiya, S.; Doré, S. Prostaglandin D2 DP1receptor is beneficial in ischemic stroke and in acute exicitotoxicity in young and old mice. Age (Dordr). 2010 Sep; 32(3):271-82.

  • Li ,W.; Wu ,S.; Ahmad ,M .; Jiang, J.; Liu, H.; Nagayama ,T.; Rose, ME.; Tyurin ,VA.; Tyurina ,YY.; Borisenko, GG.; Belikova, N.; Chen J, Kagan VE, Graham SH. The cyclooxygenase site, but not the peroxidase site of cyclooxygenase-2 is required for neurotoxicity in hypoxic and ischemic injury. J Neurochem. 2010 May;113(4):965-77.

  • Ahmad, M.; Zhang, Y.; Liu ,H.; Rose, ME.; Graham ,SH. Prolonged opportunity for neuroprotection in experimental stroke with selective blockade of cyclooxygenase-2 activity. Brain Res. 2009 Jul 7; 1279:168-73.

  • Ahmad ,M .; Rose, ME.; Vagni ,V.; Griffith, RP.; Dixon ,CE.; Kochanek ,PM.; Hickey, RW.; Graham ,SH. Genetic disruption of cyclooxygenase-2 does not improve histological or behavioral outcome after traumatic brain injury in mice. J Neurosci Res. 2008

  • Ahmad, M .; Ahmad, AS.; Zhuang, H.; Maruyama ,T.; Narumiya ,S.; Doré, S. Stimulation of prostaglandin E2-EP3 receptors exacerbates stroke and excitotoxic injury. J Neuroimmunol. 2007 Mar;184(1-2):172-9.

  • Ahmad, M .; Yousuf ,S.; Khan, MB.; Hoda, MN.; Ahmad ,AS.; Ansari ,MA.; Ishrat ,T.; Agrawal, AK.; Islam, F. Attenuation by Nardostachys jatamansi of 6-hydroxydopamine-induced parkinsonism in rats: behavioral, neurochemical, and immunohistochemical studies. Pharmacol Biochem Behav. 2006 Jan; 83(1):150-60.

  • Ahmad ,M .;Saleem ,S.; Ahmad ,AS.; Yousuf ,S.; Ansari ,MA.; Khan, MB.; Ishrat ,T.; Chaturvedi, RK.; Agrawal ,AK.; Islam, F. Ginkgo biloba affords dose-dependent protection against 6-hydroxydopamine-induced parkinsonism in rats: neurobehavioural, neurochemical and immunohistochemical evidences. J Neurochem. 2005 Apr; 93(1):94-104. (Equal Contribution)