Dr. Dilip Manikrao Mondhe

Cancer Pharmacology Division
CSIR - Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: dmmondhe@iiim.ac.in, dilipmondhe@yahoo.com, dilip_m7@rediffmail.com

Positions Held  
Position Held Date Organization
Senior Principal Scientist 2012 - Present CSIR-IIIM
Principal Scientist 2006 - 2012 CSIR-IIIM
Senior Scientist 2002-2006 CSIR-IIIM
Scientist 1997-2002 CSIR-IIIM

Manager (Animal House)

1990-1997

Bharat Immunologicals & Biologicals Corporation Limited (BIBCOL), Bulandshahr (UP) 203001

Biotechnology Trainee 1989-1990 Bharat Immunologicals & Biologicals Corporation Limited (BIBCOL), Bulandshahr (UP) 203001
Livestock Development Officer 1987-1989

Directorate of Animal Husbandry, Maharashtra State, Pune. (A.I. Sub-Centre, Meetewani, Distt.- Bhandara) Maharashtra.

 
Honors and Awards  
  • Have been a recipient of Junior Research Fellowship of Indian Council of Agricultural Research, New Delhi in 1985 in Veterinary Obstetrics & Gynaecology.

  • Member, Editorial Board, Journal of Pharmaceutical and Biomedical Sciences (JPBMS).

  • Recognised as Guide for Ph.D. students by

    • Shri Mata Vaishno Devi University, Katra (J & K),
    • Guru Nanak Dev University, Amritsar and 
    • Sher-e-Kashmir University of Agricultural Sciences & Technology – Jammu.
    • Academy of Scientific & Innovative Research (AcSIR), New Delhi
Membership
  • Indian Society for the Study of Animal Reproduction (ISSAR)

  • Canadian Association for Laboratory Animal Science (CALAS)

  • Laboratory Animal Science Association of India (LASAI)

  • Indian Society of Veterinary Pharmacology & Toxicology (ISVPT)

Research Area

Presently engaged in evaluating in vivo anticancer potential of natural and semi-synthetic natural products in murine models of different cancers as per NCI protocols.  For this purpose, established nine models of murine cancer at IIIM, Jammu.

Areas of Research Interest:

  • Studying in vivo anticancer potential of natural products using human cancer xenografts in nude / SCID mice.

  • Non-invasive detection and quantification of tumors using in vivo imaging system.

  • Stem cell biology.

Scientific Contribution:

Established a small facility housing delicate strains of laboratory mice (including immunodeficient mice) for studying in vivo anticancer potential of natural and semi-synthetic natural products in murine models. Studied over 300 samples for their anticancer potential in murine and human cancer xenograft models which lead to publications and patents.  

Supervised more than 30 students from different universities for their project work forming a part of their post-graduate degree programmes like M. Sc. /M. Tech / M. Pharm in Biotechnology / Biosciences / Pharmaceutical Sciences / Biochemistry / Medical Laboratory Technology.

Presently guiding eight Ph.D. students registered with Guru Nanak Dev University, Amritsar, Shri Mata Vaishno Devi University, Katra and Academy of Scientific & Innovative Research (AcSIR), New Delhi.

Publications
  • Mondhe, D.M.; Deopurkar, V. L.; Hukeri,V.B.; Mantri, A. M.; Hingane,V. R.; Kaikini., A.S. Serum FSH and Oestradiol -17β concentrations in postpartum anoestrous crossbred cows.Ind. J. Anim. Reprod.(1989), 10 (1) 6-9.

  • Mondhe,D. M. Use of laboratory animals in the quality control of Trivalent Oral Polio Vaccine (TOPV).Paper presented at ‘Third Asian Congress of Parasitology and Satellite Symposium on Production, Care and Use of Lab. Animals in Experimental Parasitology”, Central Drug Research Institute, Lucknow, India. (1993), Feb. 18-21.

  • Tasduq, S A .; Mondhe,D M.; Gupta,D K. ; Baleshwar,M.; Johri,R K. Reversal of fibrogenic events in liver by Emblica officinalis (Fruit), an Indian Natural Drug. Biol. Pharm. Bul.(2005), 28(7): 1304-1306.

  • Mondhe,D.M.. Defined Animal Models in Biomedical Research Compendiun on “Advances in Animal Health and Production”, Sher-e-Kashmir
    University of Agricultural Sciences and Technology, Jammu – 181102. (2005),pp:80-84.

  • Saxena,A. K. ; Singh,Shashank K.; Mondhe,D. M.;Qazi , G. N. Status of developments in Herbal Medicine, Phytopharmaceuticals and other natural
    products in India. In: L.S.R. Arambewela, S Wimalasena and Gunawardene (eds.) “Herbal Medicine, Phytopharmaceuticals and other Natural Products: Trends and Advances”. ISBN: 955-9244-30-2, NAM S&T Centre, India and Institute of Chemistry, Colombo, Srilanka;(2006) pp: 24-40, .

  • Mondhe, D. M.; Pal,H. C.; Sharma,A. K.; Saxena,A. K. In vivo screening of potential anticancer natural products. Compendium on “Advances
    in Clinical Pharmacokinetics and Drug Delivery Systems”, Sher-e-Kashmir University of Agricultural Sciences and Technology, Jammu – 181102. pp:30-35, (2006)

  • Singh,S. K. .; Bhusari,S. ; Singh,R.; Saxena, A. K.; Mondhe,D. M. ; Qazi,G. N. Effect of acetyl 11-keto beta-boswellic acid on metastatic growth factor responsible for angiogenesis Vascular Pharmacology (2007)46: 333–337. Impact factor : 2.207.

  • Singh,S. K. ; Shanmugavel,M. ; Kampasi,H.; Mondhe,D. M.; Rao,J. M.; Adwankar,M. K.; Saxena, A. K. ; Qazi,G. N. Chemically standardized isolates from Cedrus deodara stem wood having anticancer activity. Planta Medica(2007) 73: 519-526. Impact factor : 2.36.

  • Yadav,A.; Katoch,R.; Vohra,S.; Khajuria,J.K.; Sood,S.; Mondhe, D.M.; Srivastava, A.K. Efficacy of praziquantel pamoate and febantel combination against various helminths of dogs. Vet. Practitioner, (2007), 8(2): 170-171. Impact factor : 0.254.

  • Sharma, PR.; Mondhe, DM.; Muthiah, S.; Pal ,HC.; Shahi ,AK.; Saxena, AK.; Qazi, GN. Anticancer activity of an essential oil from Cymbopogon flexuosus. Chemico-biological interactions ( 2009) , 179,(2-3):160-8.Impact factor : 3.060.

  • Malik,Fayaz.; Kumar, Ajay. ; Bhushan,Shash.i; Mondhe,D. M.; Pal,Harish C.; Sharma,Rohit.; Khajuria,Anamika.; Singh, Surjeet.; Singh,Gurdarshan.; Saxena,Ajit K.; Suri, Krishan A.; Qazi,Ghulam N.; Singh,Jaswant.  Immune modulation and apoptosis induction: Two sides of antitumoural activity of a standardised herbal formulation of Withania somnifera.  European Journal of Cancer ( 2009),45(8):1494-1509. Impact factor : 5.536.

  • Mukherjee, A. ; Hazra, S.; Dutta,S.; Shanmugavel,M.; Mondhe,D. M.; Sharma,P. R. ; Singh,S. K.; Saxena,A. K.; Qazi ,G. N. ; Sanyal,U.   Antitumor efficacy and apoptotic activity of substituted chloroalkyl 1H-benz[de]isoquinoline-1,3-diones: a new class of potential antineoplastic agents.  Invest New Drugs ,(2011),29(3): 434-442 . DOI 10.1007/s10637-009-9372-z Impact factor 3.357.

  • Verma,Monika.; Bhushan,Shashi.; Singh,Shashank K.; Mondhe,D.M.; Pal,Harish C.; Sharma,V.K.; Dutt,Prabhu;Kapahi, B.K.;Saxena, A.K..   Cytotoxic, anti-tumor and mitochondrial dependent apoptotic potential of n-hexane fraction from Polyalthia longifolia leaves.   Submitted online to Toxicology in vitro on ,(2009)Dec 04, (Manuscript No. TIV-D-07-00468).

  • Jaganathan,Saravana Kumar; Mondhe,D.; Wani,Z. A.; Pal,Harish C.; Mandal,Mahitosh .   Effect of Honey and Eugenol on Ehrlich Ascites and Solid Carcinoma. J Biomed Biotechnol. (2010); 2010: 989163. Epub 2010 Mar 28. doi: 10.1155/2010/989163 Impact factor 2.436.

  • Jaganathan, SK.; Mazumdar, A.; Mondhe, D.; Mandal, M.  Apoptotic effect of eugenol in human colon cancer cell lines.   Cell Biol Int. (2011) Jun 1; 35(6):607-15. PMID: 21044050 Impact factor 1.747.

  • Mukherjee,A. ; Dutta,S.; Shanmugavel,M.; Mondhe,D. M.; Sharma,P. R.; Singh,S. K.; Saxena,A. k.; Sanyal, U.  6-Nitro-2-[3-(hydroxypropyl)]-1H-benz[de]isoquinoline-1,3-dione, a potent antitumor agent, induces cell cycle arrest and apoptosis.  J. Exp. Clin Cancer Res.(2010),29(1):175-182.Impact factor 2.15.

  • Chashoo,Gousia; Singh,Shashank; Sharma,Parduman; Mondhe,Dilip; Dar,Abid; Saxena,Arpita; Singh,Samar; Shah,Bahwal; Taneja,SC; Saxena,AK.  A propionyloxy derivative of11-keto- -boswellic acid induces apoptosis in HL-60 cells mediated through topoisomerase I & II inhibition.   Chem Biol Interact.(2011) ,189(1): 60-71, . Impact factor : 3.060.

  • Kumar, A; Malik, F.; Bhushan, S.; Shah, BA.; Taneja, SC.; Pal ,HC.; Wani ,ZA.; Mondhe, DM.; Kaur, J.; Singh, J.  A novel parthenin analog exhibits anti-cancer activity: Activation of apoptotic signaling events through robust NO formation in human leukemia HL-60 cells. Chem Biol Interact. (2011) Sep 30; 193(3):204-15. doi: 10.1016/j.cbi.2011.06.006. Epub 2011 Jun 29. PMID: 21741372 Impact factor : 3.060.

  • Khan ,S.; Chib, R.; Shah, BA.; Wani ,ZA.; Dhar, N.; Mondhe, DM.; Lattoo, S.; Jain, SK.;Taneja ,SC.; Singh, J. A. cyano analogue of boswellic acid induces crosstalk between p53/PUMA/Bax and telomerase that stages the human papillomavirus type 18 positive HeLa cells to apoptotic death. Eur J Pharmacol. (2011), Jun 25;660(2-3):241-8. Epub 2011 Apr 2. PMID: 21440536 Impact factor : 2.737.

  • Reddy, DM.; Qazi, NA.; Sawant ,SD.; Bandey, AH.; Srinivas, J.; Shankar, M.; Singh, SK.; Verma ,M.; Chashoo, G.; Saxena, A.; Mondhe, D.; Saxena ,AK.; Sethi, VK.; Taneja ,SC.; Qazi ,GN.; Sampath, Kumar HM.  Design and synthesis of spiro derivatives of parthenin as novel anti-cancer agents.  Eur J Med Chem. (2011), Aug;46(8):3210-7. Epub 2011 Apr 29. PMID: 21620534 Impact factor : 3.509.

  • Chashoo, G.; Singh, SK.; Mondhe, DM.; Sharma, PR.; Andotra, SS.; Shah, BA.; Taneja, SC.; Saxena, AK.   Potentiation of the antitumor effect of 11-keto-β-boswellic acid by its 3-α-hexanoyloxy derivative.  Eur J Pharmacol. (2011) Oct 15;668(3):390-400. Epub 2011 Jul 30. PMID: 21821018 Impact factor : 2.737.

  • Kamal, A.;Srikanth ,YV.; Khan M,Naseer Ahmed.; Ashraf, M.; Reddy MKashi. ; Sultana, F.; Kaur, T.;Chashoo ,G.; Suri ,N.; Sehar, I.; Wani, ZA.; Saxena, A.; Sharma, PR.; Bhushan, S; Mondhe, DM; Saxena, AK.  2-Anilinonicotinyl linked 2-aminobenzothiazoles and [1,2,4]triazolo[1,5-b] [1,2,4]benzothiadiazine conjugates as potential mitochondrial apoptotic inducers.  Bioorg Med Chem. (2011), Dec 1;19(23):7136-50. Epub 2011 Oct 13. PMID: 22047801 Impact factor : 3.157.

  • Quirishi,Yasrib.; Hamid,A.; Sharma,P. R.; Wani,Z. A. ; Mondhe,Dilip M.; Singh,Shashank K.; Zargar, M.A.; Andotra,Samar S.; Shah,Bhahwal Ali.; Taneja,Subhash C. ; Saxena,Ajit Kumar.  PARP cleavage and perturbance in mitochondrial membrane potential by 3-α-propionyloxy-β-boswellic acid results in cancer cell death and tumor regression in murine models.  Future Oncol.(2012), 8(7): 867-881 PMID:22830406 Impact factor : 3.163.

  • Chanda,D.; Bhushan,S.; Guru,S. K. ; Shanker,K.; Wani,Z.A.; Rah, B.A.; Luqman,S.; Mondhe,D. M.; Pal,A. ; Negi,A. S. Anticancer activity, toxicity and pharmacokinetic profile of an indanone derivative.  Eur J Pharmace Sci ,(2012) 47, 988–995. Impact factor : 3.536.

  • Qurishi ,Y.; Hamid, A.; Sharma ,PR.; Wani, ZA.; Mondhe, DM.; Singh, SK.; Zargar, MA.; Andotra, SS.; Shah, BA.; Taneja ,SC.; Saxena ,AK. NFκB Down-regulation and PARP Cleavage by Novel 3-α-Butyryloxy-β-boswellic Acid Results in Cancer Cell Specific Apoptosis and in vivo Tumor Regression.  Anticancer Agents Med Chem. (2012), Nov 13. 13(5):777-90 [Epub ahead of print] PMID: 23157593. Impact factor : 5.38.

  • Bhushan ,S.;  Kakkar, V.; Pal ,HC.; Guru, SK.; Kumar, A.; Mondhe, DM.; Sharma, PR.; Taneja ,SC.; Kaur, IP.; , J. Saxena AK.  Enhanced Anticancer Potential of Encapsulated Solid Lipid Nanoparticles of TPD: A Novel Triterpenediol from Boswellia serrata. Mol Pharm. (2013) Jan 7;10(1):225-35. doi: 10.1021/mp300385m. Epub 2012 Dec 13. PMID: 23237302. Impact factor : 4.782.

  • Majeed,R.;  Hamid,A.; Sangwan,P L. ; Chinthakindi, P K.;  Koul,S;  Rayees,S.; Singh, G.; Mondhe,D M .;   Mintoo,M J.;  Singh,S K.;  Rath,S K.;  Saxena,A K. Inhibition of phosphotidylinositol-3 kinase pathway by a novel naphthol derivative of betulinic acid induces cell cycle arrest and apoptosis in cancer cells of different origin. Cell Death & Disease,(2014), 01/2014; 5:e1459. doi: 10.1038/cddis.2014.387. IF: 6.04.

  • Qazi,A. K.; Hussain,A.; Aga,M.; Ali,S.; Taneja,S.C.; Sharma, P.R.; Saxena,A.K.; Mondhe,Dilip M.; Hamid,Abid.  Cell specific apoptosis by RLX is mediated by NFB in human colon carcinoma HCT-116 cells. BMC Cell Biology,(2014), 15 (36): .  IF: 2.81.

  • Akindele,A. J.; Mahajan,G.; Wani,Z.A. ; Sharma,S.; . Satti,N. K. Olufunmilayo O. Adeyemi, Mondhe, Dilip M..; Saxena,Ajit K.; Anticancer Activity of the Phytomedicine DAS-77. Integrative Cancer Therapies 1–8,  214 DOI: 10.1177/1534735414555807.

  • Qazi,A.K.; Hussain,A.; Khan,Saima.; Aga, Mushtaq Ahmad. ; Behl,A.; Ali, Shakir.; Singh,S. K.; Taneja,S. C.; Shah,B.A.; Saxena,A. K.; Mondhe,D.; Hamid,A. Quinazoline based small molecule exerts potent tumor suppressive properties by inhibiting PI3K/akt/FoxO3a signalling in experimental colo cancer.Cancer Letters(2014),12/2014; DOI:10.1016/j.canlet.2014.12.034. IF: 5.02.

  • Akindele, A.J.;  Wani,Z.; Mahajan, G.;  Sharma, S.; Aigbe,F. R.; Satti,N.; Adeyemi,Olufunmilayo Olaide.; Mondhe,Dilip Manikrao. Anticancer activity of Aristolochia ringens Vahl. (Aristolochiaceae). Journal of Traditional and Complementary Medicine 5 (2015) ,35-41.

  • Pathania,A. S.; Wani,Z.A.; Guru,S.K.; Kumar,S.; Bhushan,S.; Korkaya,H. ; Darren,F S.; Kumar,A.; Mondhe, Dilip M.; Ahmed,Z.; Chandan,B.K.; Malik,F. The anti-angiogenic and cytotoxic effects of the boswellic acid analog BA145 are potentiated by autophagy inhibitors. Molecular Cancer ( 2015), 14:6  doi:10.1186/1476-4598-14-6. Published: 21 January 2015 IF: 5.40.

  • Jaganathan, S. K.; Mondhe,D.; Wani, Z. A.; Supriyanto,E. Evaluation of Selected Honey and One of Its Phenolic Constituent Eugenol against L1210 Lymphoid Leukemia. The Scientific World Journal Volume (2014), Article ID 912051, 3 pages. Doi10.1155/2014/912051.

  • Akindele, A.J.; Wani, Z.A.; Sharma,S.; Mahajan,G.; Satti,N. K.; Adeyemi,O. O. ; Mondhe, D.M. ; Saxen, A.K. In Vitro and In Vivo Anticancer Activity of Root Extracts of Sansevieria liberica Gerome and Labroy (Agavaceae). Evidence-Based Complementary and Alternative Medicine, (2015), Article ID 560404, 11 pages doi.org/10.1155/2015/560404. IF: 2.175.

  • Rehman, S.U; Rah, BA; Lone, S.H.; Rasool, R.U.; Farooq, S.; Nayak, D.; Chikan, N.A.; Chakraborty, S.; Behl, A.; Mondhe, D.M.; Goswami, A.; Bhat, K.A.. Design and synthesis of antitumour Heck coupled Sclareol analogues: Modulation of BH3 family members by SS-12 in autophagy and apoptotic cell death.  J Med Chem. (2015), Mar 31. [Epub ahead of print] PMID: 25825934.

  • Singh, B. ; Kumar, A.; Joshi,P.; Guru,S. K.; Kumar, S.; Wani,Z. A.; Mahajan,G.; Hussain,A.; Qazi,A. K.; Kumar, A.;Bharate, S.S.; Gupta, Bishan D.;Sharma, Parduman R. ; Hamid,Abid.; Saxena,Ajit K.; Mondhe, Dilip M.; Bhushan,Shashi.; Bharate,Sandip B.;Vishwakarma, Ram A. Colchicine derivatives with potent anticancer activity and reduced P-glycoprotein induction liability. Organic & Biomolecular Chemistry. (2015) Apr 21. DOI: 10.1039/c5ob00406c.

  • Singh, A.; Fatima, K.; Singh, A; Behl, A.; Mintoo, M.J.; Hasanain, M.; Ashraf, R.; Luqman ,S.; Shanker, K.; Mondhe , DM.; Sarkar, J.; Chanda, D.; Negi, AS. Anticancer activity and toxicity profiles of 2-Benzylidene indanone lead molecule. Eur J Pharm Sci. (2015) Apr 28. pii: S0928-0987(15)00175-X. doi: 10.1016/j.ejps.2015.04.020. [Epub ahead of print].

  • Wani, Z.A.; Pathania, A.S.; Mahajan,G.; Behl, A.; Mintoo, M.J.; Guru,S.K. ; Viswanath, A.; Malik, F.; Kamal, A.; Mondhe,Dilip M.. Anticancer activity of a novel quinazolinone-chalcone derivative through cell cycle arrest in pancreatic cancer cell line. Journal of Solid Tumors, (2015), Vol. 5, No. 2 pp: 73-85.

Patents

  • Johri,R K.; Tasaduq,S A.; Singh,K.; Gupta, D K.; Kapahi, B K.; Mondhe,D M. ; Jain, S M.; Suri,O P.; Bedi,K L.; Qazi,G N .“Herbal hepatocurative agent against CYP-450 bioactivation and free radical mediated drug toxicity (including anti-tubercular drugs)”.(Indian patent (DEL 0100/2002) (PCT/IB 02/00835; dated 26.03.2002)).

  • Johri,R K.; Tasaduq,S A.; Singh,K.; Gupta,D K. ; Kapahi,B K.; Mondhe,D M. ; Jain,S M.; Suri,O P.; Bedi ,K L. ; Qaz,G N.“Hepatocurative effect of Emblica officinalis against CYP-450 bioactivation hepatotoxicity of drugs”. (US Patent No. 7,001,619; dated 21.02.2006 GRANTED.)

  • Saxena ,AK.; Gupta ,BD.; Kapahi, BK.; Shanmugavel,M.; Mondhe ,DM.; Qazi ,GN.; Kumar, Vijay. ; Mathan, G.Bioactive extract and fraction from Butea monosperma for the treatment of Hepatocellular Carcinoma.. I(ndian Patent (DEL No. 01356/2005 dtd. 26.5.2005) US Appl. No. 11/440,790; dated 25.05.2006 (USPGPUB: 20060280817)PCT/IB 06/01355; dated 24.05.2006).

  • Taneja, S.C.; Singh, Jaswant.; Saxena, A.K.; Shahi, A.K.; Sethi, V.K.; Mondhe, D.M.; Singh, Surjeet; Koul, M.K.; Chandra,Suresh.; Andotra, S.S.; Kumar, Ajay; Bhushan Shashi.; Singh, S.K.; Shanmugavel, M.; Sharma, P.R. ; Qazi, G.N.A bioactive essential oil fraction from Cymbopogon flexuosus (Nees Ex Steud.) Wats. Useful for cytotoxicity and anticancer activity. ( Indian patent (0125NF2006/IN; dated 25/01/2006) (1322/DEL/2007 dtd.19.06.2007)).

  • Qazi ,Ghulam Nabi.; Taneja, Subhash Chandra.; singh ,Jaswant.; Saxena ,Ajit Kumar.; Sethi, Vijay Kumar.; Mondhe, Dilip Manikrao.; Kapahi ,Bal Krishan.; Bhushan, Shashi.; Andotra ,Samar Singh.; Shah ,Bhahwal Ali.; singh,Surjeet.; Pal,Harish Chandra.; Malik ,Fayaz.; Kumar, Ajay. ; Sharma, Madhunika.Induction of apoptosis in cancer cells by a natural product from Boswellia species and its usefulness as anti-cancer agent.(Indian patent (0151NF2006; dated 01/04/2006) (0570/DEL/2007; dated 6/03/2007).

  • Qazi, Ghulam Nabi.; Taneja ,Subhash Chandra.; Jaswant ,singh.; Saxena, Ajit Kumar.; Sethi, Vijay Kumar.;Shah, Bhahwal Ali.; Kapahi, Bal Krishan.; Andotra, Samar Singh.; kumar,Ajay. ; Bhushan ,Shashi.; Malik,Fayaz.; Mondhe ,Dilip Manikrao.; Shanmugavel,Muthiah; Singh,Surjeet; Verma, Monika; Singh,Shashank Kumar.Cytotoxicity and induction of apoptosis in cancer cells by semi-synthetic analogues of Boswellic acids for their use as anti-cancer agents. (Indian patent (0201NF2006; dated 01/09/2006) (0606/DEL/2008 dtd 11.03.2008)).

  • Qazi, G.N.; Taneja, S.C.;Singh, Jaswant; Malik Fayaz.; Saxena, A.K.; Shahi, A.K.; Suri, K.A.; Mondhe, D.M.; Satti, N.K.; Kumar, Arun.; Kumar, Ajay; Bhushan, Shashi; Khan, Inshad; Shanmugavel, M.; Singh, Chandra, Harish; Gupta, Amit; Kumar, Manoj; Sharma, Sandeep and Singh, Surjeet. A novel standardized synergistic pharmaceutical formulation with Th1- dominant immune up-regulating and anticancer activities.(Indian patent (0202NF2006; dated 06/09/2006) (1321/DEL/2007 dtd 19.06.2007)).

  • Qazi, Ghulam Nabi; Saxena ,Ajit Kumar; Muthiah ,Shanmugavel.; Mondhe ,DilipManikrao.; Sharma ,Parduman Raj.; Singh ,Shashank Kumar.; Sanyal ,Utpal.; Mukherjee, Asana; Hazra ,Suva.; Dutta, Sushanta.Novel substituted 1H-benz[de]isoquinoline-1,3-diones as anticancer agents. (Indian patent (0006/NF/2006; dated 12/01/2006) (0072/DEL/2007; dated11/01/2007)).

  • Qazi, G.N.; Saxena, A. K.; Muthiah, Shanmugavel.; Mondhe, D.M.; Sharma, P.R.; Singh, S.K.; Sanyal, U.; Mukherjee, A.; Hazra S. ; Dutta, S. Substituted 2-[2-(hydroxyethyl)]- and [3-(hydroxypropyl)]-1H-benz[de]isoquinoline-1, 3-diones as anticancer agents. (Novel substituted 1H-benz[de]isoquinoline-1, 3-diones as anticancer agents) . (Indian patent (0078/NF/2007; dated 27/04/2007)).

  • Koul, S; Reddy, MV;Thota ,N; Koul ,JL; Sangwan ,PL; Taneja, SC; Kumar, A.; Khan ,IA.; Kalia, NP.; Abdullah ,ST.; Johri, RK.; Tikoo, AK.; Tikoo ,MK.; Sharma ,S.; Singh, S.; Singh, G.; Saxena ,AK.; Mondhe, DM.; Agrawal, SK.; Wakhloo ,BP.; Qazi ,GN.Novel aromatic amides as potentiators of the bioefficacy of drugs.( Indian patent (0113NF2008; dated 13.06.2008)).

  • Ishar ,MPS.; Singh, Lakhwinder.; Singh ,Rajinder.; Saxena, A K.; Mondhe, D M.; Agrawal, S K.; Pal, H C. Novel substituted 2,2,6-Trimethyl-7,9,10-trioxa-tricyclo[6.2.2.01,6]dodec-11-enes (Endoperoxides). (Indian Patent (0033NF2009, dated 23.2.2009)).

  • Bora, TC.;Mazumder ,S.; Gogoi, BK.; Rao, PG.; Mondhe, DM.; Saxena, AK. Antimicrobial and anti-cancer lactone metabolite from Aspergillus elegans growing in Asparagus racemosus, Willd., and the process for production thereof..( Indian Patent (0131DEL2010, August 2009)).

  • Kamal,A. ; Srikanth,Y.V.V.; Khan,M.N.A.; Ashraf,M.; Sehar,I. ; Chashoo,G. ; Sharma,P.R. ; Dar, A.H.;Bhushan,S. ; Singh,S.K.; Mondhe,D.M.; Saxena,A. K. 2-Anilino nicotinyl linked 2-amino benzothiazole conjugates as potential anticancer agents, apoptosis inducers and process for the preparation thereof.  . (Indian and PCT patents filed (August 2010)).

  • Vishwakarma,R.A. ; Sawant,SD.; Singh,PP; Dar,AH. ; Nargotra,Amit.; Sharma,PR.; Mondhe,DM.; Saxena,AK ; Mahesuni,Srinivas.; Qazi, Assif.; Hussain,Aashiq.;; Mahajan,Priya .Synthesis and biological evaluation of isoform selective analogs of Tetrazolyl-Quinazolinone scaffold as anticancer agents: PI3K-α/δ inhibitors.(Indian Patent (February, 2012)).

  • Vishwakarma,R.A.; Bharate,Sandip.; Kumar,Ajay.; Singh,Baljinder.; Kumar,Ashok.; Bhushan,Shashi.; Dar, AH.; Joshi,Prashant.; Guru,SK.; kumar, Suresh.; Hussain, Aashiq.; Qazi,Asif.; Bharate,Sonali.; Sharma,PR.; Saxena,AK.; Mondhe,DM.; Mahajan,Girish.; Wani,ZA. Colchicine analogs with reduced p-glycoprotein substrate and induction liability. (Indian Patent, 0059NF2014 (dated: 03.03.2014).2929DEL2014 (dated 14.10.14)).

  • Vishwakarma, R.A.; Bharate ,Sandip Bibishan.; Bhushan ,Shashi.; Mondhe ,Dilip Manikrao.; Jain, Shreyans Kumar.; Samdarshi,Meena.; Kumar, Guru Santosh. ;Singh,Pathania Anup. ; Kumar, Suresh.; Behl ,Akanksha.; Mintoo, Mubashir Javed.; Bharate ,Sonali Sandip.; Joshi, Prashant.Cyclin-dependent kinase inhibition by 5,7-dihydroxy-8-(3-hydroxy-1-methylpiperidin-4-yl)-2-methyl-4H-chromen-4-one analogs. ( Indian Patent: 1142DEL2013(dated 17.4.2013); PCT/IN2014/000239).

  • Vishwakarma R.A.; Bharate, Sandip Bibishan.; Bhushan, Shashi.; Mondhe ,Dilip Manikrao.; Jain, Shreyans Kumar.; Samdarshi,Meena.; Kumar,Guru Santosh.; Pathania, Anup Singh.; Kumar ,Suresh. Behl, Akanksha.; Mintoo, Mubashir Javed.; Bharate ,Sonali Sandip.; Joshi, Prashant. Rohitukine analogs as cyclin-dependent kinase inhibitors and a process for the preparation thereof. (International Publication No. WO 2014/170914 A1 dated 23.10.2014).

  • Thanusha, Thatikonda.; Kumar, Suresh.; Singh,Umed.; Mahajan,Priya.; Mahajan,Girish.; nargotra,Amit.; Malik,Fayaz.; Mondhe,Dilip.; Vishwakarma,R. ; Singh,Parvinder Pal. Novel 1,3,5-Triazene based PI3K inhibitors as anticancer agents and a process for the preparation thereof.( Indian patent 0127NF2014 dated 26.05.2014).
  • Singh Negi,Arvind .; Singh,Aastha.; Luqman,Suaib.; Chanda,Debabrata.;Mondhe, Dilip Manikrao .; Kumar Saxena,Ajit.; Fatima,Kaneez.; Singh,Arjun. Anticancer activity of 2-benzyl-3-aryl indanone derivatives and process of preparing the same.(Indian Patent Dec. 2014).

  • Singh,Umed. ; Chashoo,Gousia.; Mahajan,Girish.; Thatikonda, Thanusha.; mahajan, Priya.;Aruri, Hari Prasad. ; Gudup,Satish Sonbarao.; Nargotra,Amit.; Mondhe, D. M.;Vishwakarma,Ram Asrey ;Singh, P. P. Novel 3-pyrimidinyl pyrrolo [2,3-b] pyridines as new anti-cancer agents and the process for the preparation thereof. (Indian Patent May 2015).
Book Chapters
  • Saxena,A. K.; Singh,Shashank K.; Mondhe,D. M. ; Qazi,G. N. Status of developments in Herbal Medicine, Phytopharmaceuticals and other natural products in India. In: L.S.R. Arambewela, S Wimalasena and Gunawardene (eds.) “Herbal Medicine, Phytopharmaceuticals and other Natural Products: Trends and Advances”. ISBN: 955-9244-30-2, NAM S&T Centre, India and Institute of Chemistry,Colombo, Srilanka; pp: 24-40, 2006.

  • Defined animal models in Biomedical Research. In “Advances in Animal Health and Production” (Eds: Mamtani,A.P. and Srivastava,A. K.).  Intas Pharmaceuticals Ltd., Ahmedabad, India, 2006.

  • In vivo screening of Potential Anticancer Natural Products. In “Advances in Clinical Pharmacokinetics and Drug Delivery System” (Ed: Srivastava,A. K.). Sher-e-Kashmir University of Agricultural Sciences & Technology, Jammu, 2007.

  • Anticancer potential of plant terpenoids. In “Biopharmaceuticals and Nano Technology in Therapeutics “ (Eds: Sultana,M.;Raina, R. ; Verma,PK; Prawez,S. ; Gupta,SK).  Sher-e-Kashmir University of Agricultural Sciences & Technology, Jammu , pp:15-31; 2013.

  • Nanotechnology and cancer- Nanoparticle(s) for cancer drug delivery.  In “Biopharmaceuticals and Nano Technology in Therapeutics “ (Eds:Sultana, M. ;Raina, R. ; Verma, PK; Prawez,S. ; Gupta,SK).  Sher-e-Kashmir University of Agricultural Sciences & Technology, Jammu , pp:83-107; 2013.

  • Basic principles of electron microscopy, confocal microscopy & biological specimen preparation.  In “Biopharmaceuticals and Nano Technology in Therapeutics “ (Eds: Sultana, M.; Raina, R.; Verma,PK; Prawez,S.; Gupta,SK ).  Sher-e-Kashmir University of Agricultural Sciences & Technology, Jammu , pp:159-172; 2013.

Research Group

1
Mr. Z. A. Wani
2
Mr. Girish Mahajan
3
Mr. Mubashir Javed Mintoo
4
Ms. Nitasha Suri
5
Mr. Ashok Kumar
6
Mr. Gaurav Gupta
7
Mohd. Ishaq Dar
8
Ms. Suraiya Jan