Dr. Mohd Jamal Dar

Cancer Pharmacology Division
CSIR - Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: jamal@iiim.ac.in

Positions Held  
Position Held Date Organization
Senior  Scientist   CSIR-IIIM
 
Membership  
  • International Society for Genomic and Evolutionary Microbiology(ISOGEM)-Life-time member

  • American Society for Investigative Pathology (ASIP)- (2009-2010)

  • American association of Experimental Biology (EB) -2010-2011

Research Area

Mohd Jamal Dar received PhD from the department of Molecular Biology and Genetics Unit ( MBGU) at Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) under the supervision of Prof. Namita Surolia. He then joined as a postdoctoral fellow at Harvard Medical School / Dana-Farber Cancer Institue with the group of Prof. Alan Engelman and worked on. HIV-1 integrase,  the enzyme responsible for the insertion of the viral DNA into host DNA, as the critical target of anti-AIDS therapy. Following this he worked as a Research Associate (Staff Scientist) with Prof. Paul Monga at University of Pittsburgh Medical Centre (UPMC) and investigated the role of wnt/beta-catenin signaling in cancer and stem cell biology.

Present Research Interest

Stem Cell Biology and Regenerative Medicine:

  • The role of wnt /beta-catenin signalling in cancer and stem cell biology.

  • The role of PI3K pathway  in cancer and stem cell biology.

Publications
  • Thompson M.D.; Dar, M. J..; Satdarshan, P.S.Monga. Pegylated interferon targets wnt signaling by inducing nuclear export of  β-catenin. Journal of Hepatology (2011), 54(3): 506-12.

  • Kari, N.; Bowen,N.; Michael, D. Thompson..; Singh,S.;William, C..; Bowen, Jr..; Dar, Mohd J..; Khillan,J.; , Dai,C.;  Satdarshan, P.S. M. Accelerated liver regeneration and hepatocarcinogenesis in mice overexpressing serine-45 mutant beta-catenin. Hepatology (2010),  51(5):1603-13.

  • Hughes, S..; Jenkins, V..; Dar, M.J..; Engelman, A..; Cherepanov, P. Transcriptional co-activator LEDGF interacts with Cdc-7 activator of S-phase kinase (ASK) and stimulates its enzymatic activity. J Biol Chem. (2010), 1.;285(1):541-54.

  • Krishnan ,L..; Matreyek, KA..; Oztop, I..; Lee ,K..; Tipper ,CH..; Li, X.; Dar, MJ.; Kewalramani ,VN.; Engelman ,A. The requirement of cellular transportin-3 (TNPO3 or TRN-SR2) during infection maps to human immunodeficiency virus type-1 capsid and not integrase.  J Virology (2010), 84(1):397-406.

  • Dar, MJ.; Monel ,B.; Krishnan ,L, Shun, MC.; Di ,Nunzio F.; Helland ,DE.; Engelman A. Biochemical and virological analysis of 18-residue C-terminal tail of HIV-1 integrase. Retrovirology (2009), 19.; 6:94.

  • McKee, CJ.; Kessl, JJ.; Shkriabai ,N.; Dar, MJ.; Engelman ,A.; Kvaratskhelia, M. Dynamic modulation of HIV-1 integrase structure and function by cellular LEDGF protein. J Biol Chem. (2008)  14.;283(46):31802-12

  • Dar, JA.; Thoker, MA.; Khan, JA.; Ali ,A.; Khan, MA.; Bhat, KH.; Dar, MJ.; Ahmed ,N.; Ahmed ,S. Molecular epidemiology of clinical and carrier strains of methicillin resistant Staphyloccus aureus (MRSA) in the hospital settings of north India. Ann Clin Microbiol Antimicrob(2006), 14.;5:22

  • Kapoor, M.; Dar, MJ.; Surolia ,A.; Surolia, N. Kinetic determinants of the interaction of Enoyl-ACP Reductase from Plasmodium falciparum with its substrates and inhibitors. Biochem Biophys Res Commun. (2001),14.; 289(4): 832-7

Current Students

1
Paramjeet Singh
2
Gurjinder Singh
3
M. Saleem Dar
4
Gayatri Jamwal