Dr. Gurdarshan Singh

PK-PD-Toxicology Division
CSIR - Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: singh_gd@iiim.ac.in

Positions Held  
Position Held Date Organization
Pr.Scientist 2011- Present CSIR-IIIM

Research

There is a regulatory requirement for assessment of toxicity/safety of a new drug entity (pure molecule/ herbal) under development.
In this context, the new drug entity is to be evaluated for acute (single dose for 14 days), sub-acute (28 days); sub-chronic (90 days) and chronic (180 days) and Reproductive toxicity study. The Safety Pharmacology evaluation is to be done for any CVA, CNS, GIT and other effects.

Publications
  • Verma, M. K.; Najar, I.A .; Tikoo, M. K.; Singh, G.; Gupta, D.K.; Anand,.R.; Khajuria, R. K.; Sharma,.S. C.; Johri,.R.K.; Development of a validated UPLC-qTOF-MS Method for the determination of curcuminoids and their pharmacokinetic study in mice. DARU Journal of Pharmaceutical Sciences (2013), 21:11

  • Rayees, S .;Sharma, R .; Singh, G.; Najar, I. A; Singh, A .; Ahamad, D. B.; Sharma, S.C .;Tikoo, M. K .; Gupta, V.K.;Sangwan, P. L.;Singh, S .; Koul, S.; Johri, R. K . Acute, sub-acute and general pharmacological evaluation of 5-(3,4-methylenedioxyphenyl)-4-ethyl-2E,4E-pentadienoic acid piperidide (SK-20): A novel drug bioavailability enhancer. Envionmental toxicology and pharmacology ( 2 0 1 3 ), 3 5, 347–359

  • Rayees, S.; Singh, G.; Singh, S.; Tikoo, M.K.; Sharma, S. C.; Satti, N. K.; Gupta, V. K.; Bedi, Y. S.; Johri, R. K. Sitopaladi, a poly-herbal formulation, inhibits IgE mediated allergic reactions. Spatula DD(2012), 2(2),75-82

  • Singh, S.; Sharma, R.; Singh, G.D.; Kaul, A.; Gupta, V.; Khajuria, A. et al.: Inhibitory potential of Euripbia prostata standardized aqueous extract for acute and chronic inflammation through iNOS, free radicals and γ-GT down regulation.  Spatula DD (2011), 1(3), 137-145

  • Singh, S.; Sharma, R.; Singh, G.D.; Kaul, A.; Khajuria, A.; Gupta, V. et al., 2011. Anti-inflammatory and anti-arthritic activity of the rhizome extract of Polygonum viviparum L. Spatula DD (2011), 1(4), 225-232

  • Najar, I.A.; Sharma, S.C.; Singh, G.D.; Koul, S.; Gupta, P.N.; Javed, S. et al., 2011. Involment of P-glycoprotein and CYP3A4 in the enhancement of etoposide bioavailability by a piperine analogue. Chemico- Biological Interactions (2011), 190, 84-90

  • Onasanwo, S.A.; Singh, G.D.; Olalaye, S.B.; Singh, S. ; Johri, R.K. Anti-histaminic potential of the fractions from Hedranthera barteri[(Hook F.)Pichon] root in rats. Nigerian Journal of Physiological Sciences (2010), 25, 37-49-6

  • Sharma, R. ; Singh, S..;Singh,G.D.; Khajuria,A.; Sidiq,T.; .Singh,S.K; Chashoo,G.; Pagoch,S.S.; Kaul,A.; Saxena,A.K.; .Johri, R.K;Taneja,S.C.  In vivo genotoxicity evaluation of a plant based antiarthritic and anticancer therapeutic agent boswellic acids in rodents. Phytomedicine (2009), 16, 1112-1118, 

  • Singh, G.D.;Ganjoo,M.; Youssouf,M.S.; Koul,A. ; Sharma,R. ; Singh, S.; sangwan,P.L.; Koul,S.; Ahamad,D.B. ; Johri,R.K. Sub-acute toxicity evaluation of an aqueous extract of Labisia pumila, a Malaysian herb. Food and Chemical Toxicology  (2009), 47, 2661- 2665

  • Malik, F.; Khajuria,A.; Bhushan,S.;  Mondhe,D.M.; Pal,H.C.;  Sharma,R.; Khajuria,A.; Singh,S.; Singh,G.D.; Saxena,A.K.; Suri, K.A.; .Qazi, G.N; Singh,J. Immune modulation and apoptosis induction: Two sides of antitumoral activity of a standard herbal formulation of Withania somnifera. European Journal of Cancer (2009),45, 1494-1509.

Patents:

  • Method for treatment of Bronchial asthma: Mukhopadhyay, S.; Chakraborty,M.; mukherjee, T.; Bandyopadhyay, A.; kar,D.; Banerjee,T.; Konar,A..; Jana,D.; Roy,S.; Bandyopadhyay,S.; Ghosh, B.; Ulaganathan,M.; Johri,R. K .; Sharma,S.C.; Singh,G.; Paul,B.; Sharma, V. M .;Gangavaram.; singh,Y. J .; Palakodety,Radha Krishna . (US 2012/0202868 A1, pub. Date Aug. 9, 2012).

  • Isolation of the Hepatopprotective Agent, acteoside from Colebrokea oppositifolia: Qazi, G.N.; Suri, O.P.; Bedi, K. L.; Suri, K.A.; Gupta, B. D.; Singh, B.J.; Kapai, B. K.; Satti, N. K.; Amina M.; Chandan, B.K.; Sharma, N.; Singh, G.(EP 161617853).

  • Koul ,S.; Reddy, M.V.; Thota ,N.; Koul, J.L.; Sangwan ,P.L.; Taneja, S.C.; Khan ,I.A.; Kumar, A.; Kalia, N.P.; Abdulla, T.S.; Johri ,R.K.; Pagoch ,S.S.; Tikoo, A.K.; Tikoo, M.K.; Saxena ,A.K.; Agarwal, S.K.; Mondhe, D.M.; Purnima, B.; Sharma,S. ; Singh,S.; Singh,G.D.; Bushari, S.;Qazi,G.N. Aromatic substituted pentadienoic acid amides, their di and tetrahydro derivatives for combination with antiinfective drugs.( NF 0113/2008).

  • Koul ,S.; Thota, N.; Reddy, M.V.;Sangwan ,P.L.; Taneja, S.C.;Khan, I.A.; Kumar, A..; Raja, A.F.; Saxena, A.K.; Agarwal, S.K.; Johri, R.K.; Abdulla ,S.T.; Singh, G.D.; Rao,B.L.; Dhar ,A.K.; Purnima, B..; Qazi ,G.N. Novel Efflux Pump Inhibitors. ( WO/2009/110002).