Dr. Bhahwal Ali Shah

Natural Product Microbes
CSIR - Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: bashah@iiim.ac.in, bashah@iiim.res.in, bhahwal@gmail.com

Positions Held  
Position Held Date Organization
Scientist 2011 - Present CSIR-IIIM
Jr. Scientist 2008 - 2011 CSIR-IIIM
Assistant Professor 2012 onwards AcSIR
Honours & Awards  
  • INDO-US Research Science and Technology Forum Fellowship for the year 2011.

  • Awarded BOYSCAST Fellowship for the Year 2011.

  • Fast Track Research Grant awarded by DST (2010)

  • Qualified for Senior Research Fellowship-2008 awarded by Council of Scientific and Industrial Research, New Delhi, India.

  • Best paper award of the Institute (2007-2008) for “A facile approach towards enantiomerically pure masked β-amino alcohols; P. Gupta,Bhahwal Ali Shah, R. Parshad, G.N. Qazi and S.C. Taneja, Green Chemistry, 2007, 9, 1120-1125”

  • 2nd best paper award of the Institute (2006-2007) for “Formation of 1,3-dioxalanes: a typical Baylis-Hillman reaction of sesquiterpene lactone parthenin; Bhahwal Ali Shah, S.C. Taneja, V.K. Sethi, P. Gupta, S.S. Andotra, S.S. Chimni and G.N. Qazi Tetrahedron. Lett., 2007, 48, 955-960.”

  • Best paper award of the Institute (2013) for “Tubulin Inhibitors from an Endophytic Fungus Isolated from Cedrus deodara; M. Kumar, M. Qadri, P. R. Sharma, A. Kumar, S. S. Andotra,T. Kaur, K. Kapoor, V. K. Gupta, R. Kant, A. Hamid, S. Johri, S. C. Taneja, R. A. Vishwakarma, S. Riyaz-Ul-Hassan, Bhahwal Ali Shah, J. Nat. Prod., 2013, 76, 194-199.

  • Best paper award of the Institute (2011) for “Tandem Catalysis by Lipase in a Vinyl Acetate-Mediated Cross-Aldol Reaction; M. Kumar, Bhahwal Ali Shah, S. C. Taneja, Adv. Synth. Cat., 2011, 353, 1207-1212

Research Area

Isolation of Natural Products

Structural modifications of Naturally Occurring Molecules

Synthetic Methodologies

 

Publications

Click here for complete list.

  • Sultan,S.; Kumar, M.; Devari, S.; Mukherjee, D.; Shah, B.A. Copper–Manganese Spinel Oxide Catalyzed Synthesis of Amides and Azobenzenes via Aminyl Radical Cations. ChemCatChem (2016), DOI: 10.1002/cctc.201501218.

  • Devari, S.; Shah, B.A. Visible light-promoted C–H functionalization of ethers and electron-deficient arenes. Chemical Communications (2016), DOI: 10.1039/C5CC08817H.

  • Kumar, A.; Qayum, A.; Sharma, P.R.; Singh, S.K.; Shah, B.A. Synthesis of β-boswellic acid derivatives as cytotoxic and apoptotic agents. Bioorganic & Medicinal Chemistry Letters (2016), 26, 76-81.

  • Sharma, S.; Gupta, S.; Khajuria, V.; Bhagat, A.; Ahmed, Z.; Shah, B.A. Analogues of Boswellic acids as inhibitors of pro-inflammatory cytokines TNF-α and IL-6. Bioorganic & Medicinal Chemistry Letters (2016), 26, 695–698.

  • Kumar, A.; Shah, B.A. Synthesis of Biaryls via Benzylic C–C Bond Cleavage of Styrenes and Benzyl Alcohols. Organic letters (2015), 17, 5232-5235.

  • Devari, S.; Kumar, A.; Shah, Bhahwal Ali. C–H functionalization of terminal alkynes towards stereospecific synthesis of (E) or (Z) 2-methylthio-1,4-ene-diones. Chemical Communications (2015), 51, 5013-5016.

  • Kumar, A.; Kumar, M.; Sharma, S.; Guru, S.; Bhushan, S.; Shah, B. A. Design, Synthesis and Bio-evaluation of Cryptophycins Based Tubulin Inhibitors. European Journal of Medicinal Chemistry (2015), 93, 55–63.

  • Deshidi, R.; Devari, S.; Shah, Bhahwal Ali. Metal free access to quinolines via C–C bond cleavage of styrenes. Organic Chemistry Frontiers (2015), 2, 515-519.

  • Kumar, M.; Kumar, A.; Rizvi, M. A; Shah, Bhahwal Ali. Acetaldehyde in asymmetric organocatalytic transformations. RSC Advances (2015), 5, 55926-55937.

  • Deshidi R.; Rizvi, M. A; Shah, Bhahwal Ali. Highly efficient dehydrogenative cross-coupling of    aldehydes with amines and alcohols. RSC Advances (2015), 5, 90521-90524.

  • Kumar, M.; Devari, S.; Kumar, A.; Sultan, S.; Ahmed, Q. N.; Rizvi, M.; Shah, B. A. Copper (II)‐Triflate‐Catalyzed Oxidative Amidation of Terminal Alkynes: A General Approach to α‐Ketoamides. Asian Journal of Organic Chemistry, (2015), doi: 10.1002/ajoc.201500022.

  • Deshidi ,R.; Devari, S.; Shah, B.A. Iodine promoted oxidative amidation of terminal alkene; Synthesis of α-ketoamides, Benzothiazoles and Quinozolines. European Journal of Organic Chemistry (2015), 2015, 1428–1432.

  • Deshidi, R.; Kumar, M.; Devari, S.; Shah, B. A. A general metal free approach to α-ketoamides via oxidative amidation–diketonization of terminal alkynes. Chemical Communications (2014), 50, 9533-9535.

  • Kumar, M.; Kumar, A.; Rizvi, M.; Mane, M.; Vanka, K.; Taneja, S. C.; Shah, B. A. Synthesis of α, β‐Unsaturated δ‐Lactones by Vinyl Acetate Mediated Asymmetric Cross‐Aldol Reaction of Acetaldehyde: Mechanistic Insights. European Journal of Organic Chemistry (2014), 5247-5255.

  • Sharma, S.; Ahmad, M.; Bhat, J. A.; Kumar, A.; Kumar, M.; Zargar, M. A.; Hamid, A.; Shah, B.A Design, synthesis and biological evaluation of β-Boswellic acid based HDAC inhibitors as inducers of cancer cell death. Bioorganic. Medicinal Chemistry Letters (2014), 24, 4729-4734.

  • Chib, R.; Kumar, M.; Rizvi, M.; Sharma, S.; Pandey, A.; Bani,  S.; Andotra, S. S.; Taneja, S. C.; Shah, B. A.Anti-inflammatory terpenoids from Boswellia ovalifoliolata. RSC Advances (2014), 4, 8632-8637.

  • Kumar, M.; Qadri, M.; Sharma, P. R.; Kumar, A.; Andotra, S. S.; Kaur, T.; Kapoor, K.; Gupta, V. K.; Kant, R.; Hamid, A.; Johri, S.; Taneja, S. C.; Vishwakarma, R. A.; Riyaz-Ul-Hassan, S.; Shah, Bhahwal Ali. Tubulin Inhibitors from an Endophytic Fungus Isolated from Cedrus deodara. Journal of Natural Products (2013), 76, 194-199.

  • Devari, S.; Deshidi, R.; Kumar, M.; Kumar, A.; Sharma, S.; Rizvi, M.; Kushwaha, M.; Gupta, A. P.; Shah, B. A. Osmium (VI) catalyzed chemoselective oxidation of allylic and benzylic alcohols. Tetrahedron Letters (2013),54, 6407–6410.

  • Kumar, M.;Shah, B. A.; Taneja, S. C. Tandem Catalysis by Lipase in a Vinyl Acetate-Mediated Cross-Aldol Reaction. Advanced Synthesis and Catalysis (2011), 353, 1207-1212.

  • Shah, B.A.; Qazi G.N.; Taneja, S.C. Boswellic acids: a group of medicinally important compounds. Natural Product Reports (2009), 26, 72-89.

Patents:

  • Mondhe , D.M.; Taneja, S.C.; Koul, S.; Dhar, J. K.; Saxena,  A.K.; Johri, R.K.; Wani,  Z.A.; Andotra, S.S.; Sharma, S.C.; Singh, S.; Gupta, P.N.; Shah, B.A.; Vishwakarma, R.A. A novel formulation useful in cancer chemotherapy. (Indian Patent Filed: 2554DEL2012).

  • Qazi, G.N.; Taneja, S.C.; Singh, J.; Saxena, A.K.; Sethi, V.K.; Shah, B.A.; Kumar, A.; Andotra, S. S.; Malik, F.; Muthiah,  S.; Agrawal, S.K. Semi-synthetic sesquiterpene lactone parthenin compound useful for cytotoxicity against cancer cell lines and anticancer activity (WO Patent Application No. PCT/IN2009/000218)

  • Qazi, G.N.; Taneja, S.C.; Singh, J.; Saxena, A.K.; Sethi, V.K.; Shah, B.A.; Kapahi, B.K.; Andotra, S.S.; Kumar,  A.; Bhushan, S.; Malik, F.; Mondhe, D.M.; Shanmugavel, M.;  Singh, S.; Verma, M.; Singh, S.K.  Cytotoxicity and induction of apoptosis in cancer cells by semi-synthetic analogues of boswellic acids for their use as anti-cancer agents (US Patent Application No. 12/401337)

  • Qazi, G.N.; Taneja, S.C.; Singh, J.; Saxena,  A.K.; Sethi,  V.K.; Shah, B.A.; Kumar, A.; Andotra, S. S.; Malik, F.; Muthiah,  S.; Agrawal, S.K. Semi-synthetic sesquiterpene lactone parthenin compound useful for cytotoxicity against cancer cell lines and anticancer activity (Indian Patent Filed: 0840DEL2008)

  • Qazi, G.N.; Taneja, S.C.; Singh, J.; Saxena,  A.K.; Sethi,  V.K.; Shah, B.A.; Kumar, A.; Andotra, S. S.; Malik, F.; Muthiah,  S.; Agrawal, S.K. Semi -synthetic sesquiterpene lactone parthenin compound useful for anti-cancer activity (Indian Patent Filed: 0839DEL2008)

  • Qazi, G.N.; Taneja, S.C.; Singh, J.; Saxena,  A.K.; Sethi,  V.K.; Shah, B.A.; Kapahi, B.K.; Andotra , S.S.; Kumar,  A.; Bhushan, S.; Malik, F.; Mondhe, D.M.; Shanmugavel, M.;  Singh, S.; Verma, M.; Singh, S.K.  In vitro and in vivo anti-cancer activity of semi-synthetic compound (Indian Patent Filed: 0606DEL2008).

Book Chapters:

  • Bhahwal Ali Shah and Subhash Chandra Taneja. In Compendium of bioactive natural products; “Structural modifications of parthenin; a sesquiterpene lactone of immense biological potential” Eds. S.C. Taneja, V.K. Gupta & B.D. Gupta, Studium Press, USA, 2010, Vol. 7, p45-76.

  • Bhahwal Ali Shah and Subhash Chandra Taneja. In Compendium of bioactive natural products; “Biological prospective of pinitol and its structurally modified products” Eds. S.C. Taneja, V.K. Gupta & B.D. Gupta, Studium Press, USA, 2010, Vol. 7, p247-266.

Current Members

1
Mr.  Ramesh Deshidi
2
Mr.  Shekaraiah Devari
3
Mr.  Arvind Kumar
4
Ms.  Simmi Sharma
5
Ms.  Shaista Sultan

Past Members

1
Mr.  Manjeet Kumar
2
Mrs.  Renu Chib

 

Facilities
1
HPLC
2
Immersion Cooler
3
SpeedVac Concentrator