Dr. Anindya Goswami

Cancer Pharmacology Division
CSIR - Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: agoswami@iiim.ac.in

Positions Held  
Position Held Date Organization
Principal Scientist 2010 - Present CSIR-IIIM
Honours & Awards  
  • Qualified in graduate aptitude test for engineering Test (NET) 2001.
Membership
  • Associate Member of the American Association for Cancer Research
  • Member of the American Society for Cell Biology.
  • Member of Indian Association of Cancer Research

Research Areas:

1

Bioactive natural products, especially from plant origin are assigned prior thrusting areas for development of anti-tumor/anti-metastatic lead molecules. For the last five years, our group has focussed researches on some important target based natural products/derivatives viz. 3-AWA (3-azido Withaferin A), DIM-16-OHG (3,3′-diindolylmethane), PODO-5 ("4′-Demethyl-deoxypodophyllotoxin) and SS-12 (Sclareol). Among them, we have successfully characterized the potential anti-invasive properties of 3-azido Withaferin A in diverse cancer models.

2
Prostate apoptotic response-4 (Par-4) is a naturally occurring pro-apoptotic protein, that selectively kills tumor cells when stimulated by apoptosis inducing agents. Containing two putative NLS , the SAC (selective for apoptosis in cancer) domain of Par-4 is known to inhibits NFkB transcriptional activity and induces FAS/FASL trafficking. Extracellular Par-4 has been found to exhibit anti-angiogenic potential. Consistently, for the last one decade, major studies reveal excellent therapeutic application of stimulated/secretory Par-4 towards metastatic inhibition. Currently, we are working on extracellular matrix remodelling during metastasis and anti-invasive role of induced/extracellular Par-4. Since, the protein Par-4 is highly physiologically relevant and abundantly present in most of the human tissue, the major challenges of our group is to improvise the availability of induced intracellular/extracellular Par-4 in pro-tumorigenic condition by natural products.
3

The other important tumor suppressor 4EBP1 is a major target for the recent development of target based therapeutics considering its prominent role in protein translation initiation. Due to hyperphosphorylation of 4EBP1, aberrant activation of downstream factors leads to cyto-protective autophagy and consequent drug resistances. With the lead natural products of our institute, our group is working on the inhibition of signalling cascades involved in aberrant protein translational initiation machinery.

Publications:

  • Nayak, D.; Chakraborty, S.; Rasool, R.; Amin, H.; Mahajan,V.; Zilla, M.K.; Gopinath,V.; Rah, B.; Gandhi, S.G.; Ali, A.; Kumar, L.D.; Goswami, A. Inhibition of Twist1 mediated invasion by Chk2 promotes premature senescence in p53 defective cancer cells. Cell Death and Differentiation, (2017), DOI: 10.1038/cdd.2017.70.

  • Rasool, R.; Nayak, D.; Chakraborty, S.; Fayeem, M.; Rah, B.; Mahajan, P.; Gopinath, V.; Katoch, A.; Iqra, Z.; Yousf, S.K.; Mukherjee, D.; Kumar,L.D.; Nargotra, A.; Goswami, A. AKT is indispensable for coordinating Par-4/JNK cross talk in p21 downmodulation during ER stress. Oncogenesis, (2017), DOI: 10.1038/oncsis.2017.41.

  • Rasool, R.U.; Rah, B.; Amin, H.; Nayak, D.; Chakraborty, S.; Rawoof, A.; Mintoo, M.J.; Yousuf, K.; Mukherjee, D.; Kumar, L.D.; Mondhe, D.M.; Goswami, A. c-FLIP inhibitory mechanism of 3-AWA mediated translational attenuation through dephosphorylation of eIF4E. Scientific Reports (2016), DOI: 10.1038/srep18800.

  • Amin, H.; Nayak, D.; Rasool,R.U.; Chakraborty, S. ; Kumar, A.  ; Yousuf, K. ; Sharma,P.R.; Ahmed,Z. ; Sharma, N. ; Magotra, A. , Mukherjee, D. ; Kumar LD; Goswami, A. Par-4 dependent modulation of cellular β-catenin by medicinal plant natural product  derivative  3-azido Withaferin A. Molecular Carcinogenesis  (2015). DOI: 10.1002/mc.22328.

  • Rah, B.; Rasool, R. U.; Nayak, D.; Yousuf, K.; Mukherjee, D.; Kumar, L. D.;  Goswami, A.  PAWR mediated BCL2 suppression promotes switching of 3-azido Withaferin A (3-AWA) induced autophagy to apoptosis in prostate cancer cells.Autophagy (2015).DOI: 10.1080/15548627.2015.10718. 

  • Rehman,S.U.;  Rah,B.;  Lone,S.H.;  Rasool,R.U.;  Farooq,S.;  Nayak, D.;  Chikan,N.A.;  Chakraborty,S;  Behl, A.;  Mondhe, D.M.; Goswami, A .; Bhat, K.A.. Design and synthesis of antitumour Heck coupled Sclareol analogs: Modulation of BH3 family members by SS-12 in autophagy and apoptotic cell death. Journal of Medicinal Chemistry. (2015) DOI: 10.1021/jm501942m.

  • Nayak, D.; Amin, H.; Rah, B.; Rasool, R.U.; Sharma, D.; Gupta, A. P.; Kushwaha, M.; Mukherjee, D.; Goswami, A.. A therapeutically relevant, 3, 3’- Diindolylmethane derivative NGD16 attenuates angiogenesis by targeting glucose regulated protein, 78 kDa (GRP78). Chemico-Biological Interactions, (2015). DOI:10.1016/j.cbi.2015.03.008.

  • Zilla, M.K.; Nayak, D.; Vishwakarma, R.A.; Sharma, P.R.; Goswami ,A.;  Ali, A.;  A convergent synthesis of alkyne-azide cycloaddition derivatives of 4-α,β-2-propyne podophyllotoxin depicting potent cytotoxic activity. European Journal of Medicinal Chemistry(2014) 77, 47-55. DOI: 10.1016/j.ejmech.2014.02.030.

  • Zilla, M. K.; Nayak, D.; Amin, H.; Rah, B.; Chakraborty, S.; Nalli, Y.; Kitchlu, S.; Goswami, A. ; Ali, A.  4'-demethyl-deoxypodophyllotoxin glucoside isolated from Podophyllum hexandrum exhibits potential anticancer activities by altering Chk-2 signaling pathway in MCF-7 breast cancer cells. Chemico-Biological Interactions (2014).DOI: 10.1016/j.cbi.2014.09.022.

  • Sinha, S.; Mishra, P.; Amin, H.; Rah, B.; Nayak, D.; Goswami, Anindya.; Kumar, N.; Vishwakarma, R.A.; Ghosal S,. A new cytotoxic quinolone alkaloid and a pentacyclic steroidal glycoside from the stem bark of Crataeva nurvala: study of anti-proliferative and apoptosis inducing property. European Journal of Medicinal Chemistry. (2013) DOI: 10.1016/j.ejmech.2013.12.017.

  • Singh, I.; Amin, H.; Rah, B.;  Goswami A. Targeting EGFR and IGF 1R: a promising combination therapy for metastatic cancer.  Front Biosci (Schol Ed). (2013) Jan 1;5:231-46.

  • Rah, B.; Amin, H.; Yousuf, K.; Khan, S.; Jamwal, G.; Mukherjee, D.; Goswami ,A. A Novel MMP-2 Inhibitor 3-azidowithaferin A (3-azidoWA) Abrogates Cancer Cell Invasion and Angiogenesis by Modulating Extracellular Par-4. PLoS ONE (2012) 7(9): e44039. doi:10.1371/journal.pone.0044039

  • Burikhanov, R.; Zhao, Y.; Goswami, A; Qiu, S.; Schwarze, S.R.; Rangnekar, V.M. The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis. Cell, (2009) 138: 377-388.

  • Goswami, A, Qiu,  S.G. ; Burikhanov,  R.; Ranganathan, P.; Rangnekar, V.M. Par-4 binds to Topoisomerase I and attenuates its DNA relaxation activity. Cancer Res. (2008) 1; 68 (15) 6190-6198.

  • Vasudevan,K.M;  Burikhanov,R.;  Goswami,  A; Rangnekar,  V.M.  Suppression of PTEN expression is essential for antiapoptosis and cellular transformation by oncogenic Ras.  Cancer Res. (2007) 67:(21) 10343-10350.

  • Goswami, A; Ranganathan, P.;  Rangnekar, V.M. The PI3K-Akt1-Par-4 Axis : A Cancer-Selective Therapeutic Target. Review, Cancer Res. (2006) 66(6): 2889-2892

  • Goswami, A; Burikhanov, R.; de Thonel, A.; Fujita, N.; Goswami, M.; Zhao, Y.; Eriksson, J. E.; Tsuruo, T.; Rangnekar, V.M. Binding and phosphorylation of Par-4 by Akt is essential for cancer cell survival. Mol. Cell (2005) 20: 33-44.

  • Gurumurthy, S.; Goswami, A; Vasudevan , K.M.; Rangnekar ,V.M. Phosphorylation of Par 4 by Protein Kinase A is critical for apoptosis. Mol. Cell. Biol. (2005) 25(3): 1146-61.

Members:

Alumni:  Dr. Sheema Khan

Outgoing doctoral members

Members Thesis title

Mr. Bilal Ahmed Rah

Molecular Signaling Based Study of a Novel 3-azido-withaferin A for Anticancer Therapeutic Potential.

Miss Hina Amin

Investigation of the role of Withaferin A/derivative in modulating signalling pathways in transformed cancer cells for inhibition of invasion and metastasis.

Current senior and junior members

1
Mr. Debasis Nayak (SRF)
2
Mr. Riyaz Ur Rasool (SRF)
3
Mr. Souneek Chakraborty (JRF)
4
Miss Archana Katoch (JRF)
Facilities
1
Fluorescence Microscopy
2
TECAN infinite 200 PRO plate reader
3
FLOID cell imaging station